UW solution for hypothermic machine perfusion of warm ischemic kidneys
Donation of kidneys from non-heart beating donors (NHBD) is increasingly being used to expand the donor pool. Warm ischemic injury of these kidneys suffered at harvest results in DGF at transplantation. In this study, we used hypothermic continuous machine perfusion preservation to mitigate this inj...
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| Veröffentlicht in: | Transplantation 2005-05, Vol.79 (10), p.1358-1361 |
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| creator | LINDELL, Susanne L COMPAGNON, Philippe MANGINO, Martin J SOUTHARD, James H |
| description | Donation of kidneys from non-heart beating donors (NHBD) is increasingly being used to expand the donor pool. Warm ischemic injury of these kidneys suffered at harvest results in DGF at transplantation. In this study, we used hypothermic continuous machine perfusion preservation to mitigate this injury using two available solutions.
Dog kidneys (beagles) were exposed to 0, 60, or 75 min of in situ warm ischemia (37 degrees C), followed by 24 to 72 hr preservation by machine perfusion with Belzer MPS solution or the UW-solution (Viaspan). Auto-transplantation was performed with immediate contralateral nephrectomy. Survival and renal function (serum creatinine) were evaluated for up to 10 days posttransplant.
Both solutions were equally effective for 72 hr machine perfusion preservation of dog kidneys giving 100% survival with only minor renal injury. Both solutions were also equally effective for preservation of kidneys exposed to 60 min of warm ischemia. However, only the UW solution gave reliable preservation (86% survival vs. 25% survival) in kidneys exposed to 75 min of warm ischemia and 24 hr machine perfusion.
UW solution used with continuous hypothermic machine perfusion preservation can rescue canine kidneys from severe warm ischemic injury. |
| doi_str_mv | 10.1097/01.TP.0000159143.45022.F6 |
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Dog kidneys (beagles) were exposed to 0, 60, or 75 min of in situ warm ischemia (37 degrees C), followed by 24 to 72 hr preservation by machine perfusion with Belzer MPS solution or the UW-solution (Viaspan). Auto-transplantation was performed with immediate contralateral nephrectomy. Survival and renal function (serum creatinine) were evaluated for up to 10 days posttransplant.
Both solutions were equally effective for 72 hr machine perfusion preservation of dog kidneys giving 100% survival with only minor renal injury. Both solutions were also equally effective for preservation of kidneys exposed to 60 min of warm ischemia. However, only the UW solution gave reliable preservation (86% survival vs. 25% survival) in kidneys exposed to 75 min of warm ischemia and 24 hr machine perfusion.
UW solution used with continuous hypothermic machine perfusion preservation can rescue canine kidneys from severe warm ischemic injury.</description><identifier>ISSN: 0041-1337</identifier><identifier>EISSN: 1534-6080</identifier><identifier>DOI: 10.1097/01.TP.0000159143.45022.F6</identifier><identifier>PMID: 15912104</identifier><identifier>CODEN: TRPLAU</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott</publisher><subject>Adenosine - pharmacology ; Allopurinol - pharmacology ; Animals ; Biological and medical sciences ; Body Temperature ; Cryopreservation - methods ; Dogs ; Female ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; Glutathione - pharmacology ; Graft Survival ; Heart Arrest - physiopathology ; Insulin - pharmacology ; Kidney - drug effects ; Kidney - physiopathology ; Kidney Transplantation ; Medical sciences ; Organ Preservation ; Organ Preservation Solutions - pharmacology ; Perfusion - instrumentation ; Raffinose - pharmacology ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Time Factors ; Tissue, organ and graft immunology</subject><ispartof>Transplantation, 2005-05, Vol.79 (10), p.1358-1361</ispartof><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c427t-adf83fed48b6758dbd51cb41d16a13229e6e6a79211d5e65f48a245e3cd0dad23</citedby><cites>FETCH-LOGICAL-c427t-adf83fed48b6758dbd51cb41d16a13229e6e6a79211d5e65f48a245e3cd0dad23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16826236$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15912104$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>LINDELL, Susanne L</creatorcontrib><creatorcontrib>COMPAGNON, Philippe</creatorcontrib><creatorcontrib>MANGINO, Martin J</creatorcontrib><creatorcontrib>SOUTHARD, James H</creatorcontrib><title>UW solution for hypothermic machine perfusion of warm ischemic kidneys</title><title>Transplantation</title><addtitle>Transplantation</addtitle><description>Donation of kidneys from non-heart beating donors (NHBD) is increasingly being used to expand the donor pool. Warm ischemic injury of these kidneys suffered at harvest results in DGF at transplantation. In this study, we used hypothermic continuous machine perfusion preservation to mitigate this injury using two available solutions.
Dog kidneys (beagles) were exposed to 0, 60, or 75 min of in situ warm ischemia (37 degrees C), followed by 24 to 72 hr preservation by machine perfusion with Belzer MPS solution or the UW-solution (Viaspan). Auto-transplantation was performed with immediate contralateral nephrectomy. Survival and renal function (serum creatinine) were evaluated for up to 10 days posttransplant.
Both solutions were equally effective for 72 hr machine perfusion preservation of dog kidneys giving 100% survival with only minor renal injury. Both solutions were also equally effective for preservation of kidneys exposed to 60 min of warm ischemia. However, only the UW solution gave reliable preservation (86% survival vs. 25% survival) in kidneys exposed to 75 min of warm ischemia and 24 hr machine perfusion.
UW solution used with continuous hypothermic machine perfusion preservation can rescue canine kidneys from severe warm ischemic injury.</description><subject>Adenosine - pharmacology</subject><subject>Allopurinol - pharmacology</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Body Temperature</subject><subject>Cryopreservation - methods</subject><subject>Dogs</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fundamental immunology</subject><subject>Glutathione - pharmacology</subject><subject>Graft Survival</subject><subject>Heart Arrest - physiopathology</subject><subject>Insulin - pharmacology</subject><subject>Kidney - drug effects</subject><subject>Kidney - physiopathology</subject><subject>Kidney Transplantation</subject><subject>Medical sciences</subject><subject>Organ Preservation</subject><subject>Organ Preservation Solutions - pharmacology</subject><subject>Perfusion - instrumentation</subject><subject>Raffinose - pharmacology</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Time Factors</subject><subject>Tissue, organ and graft immunology</subject><issn>0041-1337</issn><issn>1534-6080</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0LtOwzAUBmALgWgpvAIKA2wJPr4mI6oIIFWiQytGy_VFDeRS7Eaob09KK3XEy1m-_xzrR-gOcAa4kI8YssU8w8MDXgCjGeOYkKwUZ2gMnLJU4ByfozHGDFKgVI7QVYyfg-dUyks02scIYDZG5fIjiV3db6uuTXwXkvVu023XLjSVSRpt1lXrko0Lvo970fnkR4cmqaJZuz35qmzrdvEaXXhdR3dznBO0LJ8X09d09v7yNn2apYYRuU219Tn1zrJ8JSTP7cpyMCsGFoQGSkjhhBNaFgTAcie4Z7kmjDtqLLbaEjpBD4e9m9B99y5uVTN8xdW1bl3XRyVkPiyG_yFIjjHN8QCLAzShizE4rzahanTYKcBq37bCoBZzdWpb_bWtSjFkb49H-lXj7Cl5rHcA90ego9G1D7o1VTw5kRNBqKC_iFyIZg</recordid><startdate>20050527</startdate><enddate>20050527</enddate><creator>LINDELL, Susanne L</creator><creator>COMPAGNON, Philippe</creator><creator>MANGINO, Martin J</creator><creator>SOUTHARD, James H</creator><general>Lippincott</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20050527</creationdate><title>UW solution for hypothermic machine perfusion of warm ischemic kidneys</title><author>LINDELL, Susanne L ; COMPAGNON, Philippe ; MANGINO, Martin J ; SOUTHARD, James H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c427t-adf83fed48b6758dbd51cb41d16a13229e6e6a79211d5e65f48a245e3cd0dad23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adenosine - pharmacology</topic><topic>Allopurinol - pharmacology</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Body Temperature</topic><topic>Cryopreservation - methods</topic><topic>Dogs</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Fundamental immunology</topic><topic>Glutathione - pharmacology</topic><topic>Graft Survival</topic><topic>Heart Arrest - physiopathology</topic><topic>Insulin - pharmacology</topic><topic>Kidney - drug effects</topic><topic>Kidney - physiopathology</topic><topic>Kidney Transplantation</topic><topic>Medical sciences</topic><topic>Organ Preservation</topic><topic>Organ Preservation Solutions - pharmacology</topic><topic>Perfusion - instrumentation</topic><topic>Raffinose - pharmacology</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Time Factors</topic><topic>Tissue, organ and graft immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>LINDELL, Susanne L</creatorcontrib><creatorcontrib>COMPAGNON, Philippe</creatorcontrib><creatorcontrib>MANGINO, Martin J</creatorcontrib><creatorcontrib>SOUTHARD, James H</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Transplantation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>LINDELL, Susanne L</au><au>COMPAGNON, Philippe</au><au>MANGINO, Martin J</au><au>SOUTHARD, James H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>UW solution for hypothermic machine perfusion of warm ischemic kidneys</atitle><jtitle>Transplantation</jtitle><addtitle>Transplantation</addtitle><date>2005-05-27</date><risdate>2005</risdate><volume>79</volume><issue>10</issue><spage>1358</spage><epage>1361</epage><pages>1358-1361</pages><issn>0041-1337</issn><eissn>1534-6080</eissn><coden>TRPLAU</coden><abstract>Donation of kidneys from non-heart beating donors (NHBD) is increasingly being used to expand the donor pool. Warm ischemic injury of these kidneys suffered at harvest results in DGF at transplantation. In this study, we used hypothermic continuous machine perfusion preservation to mitigate this injury using two available solutions.
Dog kidneys (beagles) were exposed to 0, 60, or 75 min of in situ warm ischemia (37 degrees C), followed by 24 to 72 hr preservation by machine perfusion with Belzer MPS solution or the UW-solution (Viaspan). Auto-transplantation was performed with immediate contralateral nephrectomy. Survival and renal function (serum creatinine) were evaluated for up to 10 days posttransplant.
Both solutions were equally effective for 72 hr machine perfusion preservation of dog kidneys giving 100% survival with only minor renal injury. Both solutions were also equally effective for preservation of kidneys exposed to 60 min of warm ischemia. However, only the UW solution gave reliable preservation (86% survival vs. 25% survival) in kidneys exposed to 75 min of warm ischemia and 24 hr machine perfusion.
UW solution used with continuous hypothermic machine perfusion preservation can rescue canine kidneys from severe warm ischemic injury.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott</pub><pmid>15912104</pmid><doi>10.1097/01.TP.0000159143.45022.F6</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adenosine - pharmacology Allopurinol - pharmacology Animals Biological and medical sciences Body Temperature Cryopreservation - methods Dogs Female Fundamental and applied biological sciences. Psychology Fundamental immunology Glutathione - pharmacology Graft Survival Heart Arrest - physiopathology Insulin - pharmacology Kidney - drug effects Kidney - physiopathology Kidney Transplantation Medical sciences Organ Preservation Organ Preservation Solutions - pharmacology Perfusion - instrumentation Raffinose - pharmacology Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Time Factors Tissue, organ and graft immunology |
| title | UW solution for hypothermic machine perfusion of warm ischemic kidneys |
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