High prevalence of hepatitis delta virus infection detectable by enzyme immunoassay among apparently healthy individuals in Mongolia
A previous study revealed a high prevalence of hepatitis B surface antigen (HBsAg) and hepatitis delta virus (HDV) RNA among 249 apparently healthy individuals (mean ± standard deviation age, 48.4 ± 13.9 years; 126 males and 123 females) in Ulaanbaatar, Mongolia. To investigate further the prevalenc...
Gespeichert in:
| Veröffentlicht in: | Journal of medical virology 2005-07, Vol.76 (3), p.333-340 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 340 |
|---|---|
| container_issue | 3 |
| container_start_page | 333 |
| container_title | Journal of medical virology |
| container_volume | 76 |
| creator | Inoue, Jun Takahashi, Masaharu Nishizawa, Tsutomu Narantuya, Luvsanbasaryn Sakuma, Mitsuru Kagawa, Yasuo Shimosegawa, Tooru Okamoto, Hiroaki |
| description | A previous study revealed a high prevalence of hepatitis B surface antigen (HBsAg) and hepatitis delta virus (HDV) RNA among 249 apparently healthy individuals (mean ± standard deviation age, 48.4 ± 13.9 years; 126 males and 123 females) in Ulaanbaatar, Mongolia. To investigate further the prevalence of HDV infection there, the same serum samples obtained from the cohort were tested for the presence of immunoglobulin G (IgG) class antibody to HDV (anti‐HDV) by a newly developed enzyme‐linked immunosorbent assay using recombinant hepatitis delta antigen protein expressed in the pupae of silkworm as the antigen probe. Anti‐HDV was detected in 42 persons (16.9%), among whom 22 (52.4%) were positive for HBsAg and 20 (47.6%) had detectable HDV RNA. Among 170 persons with anti‐HBc in the absence of HBsAg, 20 (11.8%) tested positive for anti‐HDV, and 1 of the 20 subjects was positive for HDV RNA. Of note, none of 55 anti‐HBc‐negative persons had anti‐HDV, supporting the specificity of the anti‐HDV assay. The optical density (OD) value of anti‐HDV was significantly higher among HDV RNA‐positive subjects (n = 21) than among HDV RNA‐negative subjects (n = 21) (2.513 ± 0.514 vs. 0.836 ± 0.550, P |
| doi_str_mv | 10.1002/jmv.20363 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_67866899</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>17636979</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4883-e12333174376b69b9e35a0791fac195c13c6f9cb8f77646d76e314c9948857323</originalsourceid><addsrcrecordid>eNqFkU1v1DAQhi0EokvhwB9AvoDEIa0dJ3Z8RC20VFugEl83a-KddF2cD-xkIZz54XjZhZ4QJ1uj531Go5eQx5wdccby45t2c5QzIcUdsuBMy0wzxe-SBeOFzKTk5QF5EOMNY6zSeX6fHPBSs1wxtiA_z931mg4BN-Cxs0j7hq5xgNGNLtIV-hHoxoUpUtc1aEfXd2k6ph_UHmk9U-x-zC1S17ZT10OMMFNo--6awjBAwG70czKCH9dzcqzcxq0m8FsfvUxY7x08JPeaNMJH-_eQfHj18v3JebZ8e_b65MUys0VViQx5LoTgqhBK1lLXGkUJTGnegOW6tFxY2WhbV41SspArJVHwwmqd0qUSuTgkz3beIfRfJ4yjaV206D102E_RSFVJWWn9X5ArKaRWW_D5DrShjzFgY4bgWgiz4cxsuzGpG_O7m8Q-2UunusXVLbkvIwFP9wBEC74J0FkXbzlZlaXIVeKOd9w353H-90Zzcfnxz-psl3BxxO9_ExC-pJuFKs2nN2dmefr5nTy9ujIX4hfZ2LZz</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>17636979</pqid></control><display><type>article</type><title>High prevalence of hepatitis delta virus infection detectable by enzyme immunoassay among apparently healthy individuals in Mongolia</title><source>MEDLINE</source><source>Access via Wiley Online Library</source><creator>Inoue, Jun ; Takahashi, Masaharu ; Nishizawa, Tsutomu ; Narantuya, Luvsanbasaryn ; Sakuma, Mitsuru ; Kagawa, Yasuo ; Shimosegawa, Tooru ; Okamoto, Hiroaki</creator><creatorcontrib>Inoue, Jun ; Takahashi, Masaharu ; Nishizawa, Tsutomu ; Narantuya, Luvsanbasaryn ; Sakuma, Mitsuru ; Kagawa, Yasuo ; Shimosegawa, Tooru ; Okamoto, Hiroaki</creatorcontrib><description>A previous study revealed a high prevalence of hepatitis B surface antigen (HBsAg) and hepatitis delta virus (HDV) RNA among 249 apparently healthy individuals (mean ± standard deviation age, 48.4 ± 13.9 years; 126 males and 123 females) in Ulaanbaatar, Mongolia. To investigate further the prevalence of HDV infection there, the same serum samples obtained from the cohort were tested for the presence of immunoglobulin G (IgG) class antibody to HDV (anti‐HDV) by a newly developed enzyme‐linked immunosorbent assay using recombinant hepatitis delta antigen protein expressed in the pupae of silkworm as the antigen probe. Anti‐HDV was detected in 42 persons (16.9%), among whom 22 (52.4%) were positive for HBsAg and 20 (47.6%) had detectable HDV RNA. Among 170 persons with anti‐HBc in the absence of HBsAg, 20 (11.8%) tested positive for anti‐HDV, and 1 of the 20 subjects was positive for HDV RNA. Of note, none of 55 anti‐HBc‐negative persons had anti‐HDV, supporting the specificity of the anti‐HDV assay. The optical density (OD) value of anti‐HDV was significantly higher among HDV RNA‐positive subjects (n = 21) than among HDV RNA‐negative subjects (n = 21) (2.513 ± 0.514 vs. 0.836 ± 0.550, P < 0.0001). The present study confirmed the extremely high prevalence of HDV infection in Mongolia, and identified a person who was positive for both anti‐HDV and HDV RNA despite negativity for HBsAg and HBV DNA probably due to viral interference. The anti‐HDV assay may be useful for further epidemiological studies on HDV infection in larger cohorts in urban and rural areas of Mongolia, where elucidation of the transmission route of HDV is required urgently. J. Med. Virol. 76:333–340, 2005. © 2005 Wiley‐Liss, Inc.</description><identifier>ISSN: 0146-6615</identifier><identifier>EISSN: 1096-9071</identifier><identifier>DOI: 10.1002/jmv.20363</identifier><identifier>PMID: 15902700</identifier><identifier>CODEN: JMVIDB</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Adult ; anti-HDV antibodies ; Base Sequence ; Biological and medical sciences ; Carrier State - epidemiology ; Carrier State - virology ; DNA, Viral - chemistry ; ELISA ; Enzyme-Linked Immunosorbent Assay ; Epidemiology ; Female ; Fundamental and applied biological sciences. Psychology ; HDV RNA ; Hepatitis Antibodies - blood ; Hepatitis B - epidemiology ; Hepatitis B Antibodies - blood ; Hepatitis B Core Antigens - immunology ; Hepatitis B Surface Antigens - blood ; Hepatitis D - epidemiology ; Hepatitis D - immunology ; Hepatitis delta Antigens - immunology ; Hepatitis delta Antigens - isolation & purification ; hepatitis delta virus ; Hepatitis Delta Virus - genetics ; Hepatitis Delta Virus - immunology ; Hepatitis Delta Virus - isolation & purification ; Human viral diseases ; Humans ; Infectious diseases ; Male ; Medical sciences ; Microbiology ; Middle Aged ; Miscellaneous ; Molecular Sequence Data ; Mongolia ; Mongolia - epidemiology ; Phylogeny ; Prevalence ; Recombinant Proteins - immunology ; Recombinant Proteins - isolation & purification ; RNA, Viral - blood ; Spectrophotometry ; Viral diseases ; Viral hepatitis ; Virology</subject><ispartof>Journal of medical virology, 2005-07, Vol.76 (3), p.333-340</ispartof><rights>Copyright © 2003 Wiley‐Liss, Inc.</rights><rights>2006 INIST-CNRS</rights><rights>Copyright (c) 2005 Wiley-Liss, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4883-e12333174376b69b9e35a0791fac195c13c6f9cb8f77646d76e314c9948857323</citedby><cites>FETCH-LOGICAL-c4883-e12333174376b69b9e35a0791fac195c13c6f9cb8f77646d76e314c9948857323</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjmv.20363$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjmv.20363$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16855327$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15902700$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Inoue, Jun</creatorcontrib><creatorcontrib>Takahashi, Masaharu</creatorcontrib><creatorcontrib>Nishizawa, Tsutomu</creatorcontrib><creatorcontrib>Narantuya, Luvsanbasaryn</creatorcontrib><creatorcontrib>Sakuma, Mitsuru</creatorcontrib><creatorcontrib>Kagawa, Yasuo</creatorcontrib><creatorcontrib>Shimosegawa, Tooru</creatorcontrib><creatorcontrib>Okamoto, Hiroaki</creatorcontrib><title>High prevalence of hepatitis delta virus infection detectable by enzyme immunoassay among apparently healthy individuals in Mongolia</title><title>Journal of medical virology</title><addtitle>J. Med. Virol</addtitle><description>A previous study revealed a high prevalence of hepatitis B surface antigen (HBsAg) and hepatitis delta virus (HDV) RNA among 249 apparently healthy individuals (mean ± standard deviation age, 48.4 ± 13.9 years; 126 males and 123 females) in Ulaanbaatar, Mongolia. To investigate further the prevalence of HDV infection there, the same serum samples obtained from the cohort were tested for the presence of immunoglobulin G (IgG) class antibody to HDV (anti‐HDV) by a newly developed enzyme‐linked immunosorbent assay using recombinant hepatitis delta antigen protein expressed in the pupae of silkworm as the antigen probe. Anti‐HDV was detected in 42 persons (16.9%), among whom 22 (52.4%) were positive for HBsAg and 20 (47.6%) had detectable HDV RNA. Among 170 persons with anti‐HBc in the absence of HBsAg, 20 (11.8%) tested positive for anti‐HDV, and 1 of the 20 subjects was positive for HDV RNA. Of note, none of 55 anti‐HBc‐negative persons had anti‐HDV, supporting the specificity of the anti‐HDV assay. The optical density (OD) value of anti‐HDV was significantly higher among HDV RNA‐positive subjects (n = 21) than among HDV RNA‐negative subjects (n = 21) (2.513 ± 0.514 vs. 0.836 ± 0.550, P < 0.0001). The present study confirmed the extremely high prevalence of HDV infection in Mongolia, and identified a person who was positive for both anti‐HDV and HDV RNA despite negativity for HBsAg and HBV DNA probably due to viral interference. The anti‐HDV assay may be useful for further epidemiological studies on HDV infection in larger cohorts in urban and rural areas of Mongolia, where elucidation of the transmission route of HDV is required urgently. J. Med. Virol. 76:333–340, 2005. © 2005 Wiley‐Liss, Inc.</description><subject>Adult</subject><subject>anti-HDV antibodies</subject><subject>Base Sequence</subject><subject>Biological and medical sciences</subject><subject>Carrier State - epidemiology</subject><subject>Carrier State - virology</subject><subject>DNA, Viral - chemistry</subject><subject>ELISA</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>HDV RNA</subject><subject>Hepatitis Antibodies - blood</subject><subject>Hepatitis B - epidemiology</subject><subject>Hepatitis B Antibodies - blood</subject><subject>Hepatitis B Core Antigens - immunology</subject><subject>Hepatitis B Surface Antigens - blood</subject><subject>Hepatitis D - epidemiology</subject><subject>Hepatitis D - immunology</subject><subject>Hepatitis delta Antigens - immunology</subject><subject>Hepatitis delta Antigens - isolation & purification</subject><subject>hepatitis delta virus</subject><subject>Hepatitis Delta Virus - genetics</subject><subject>Hepatitis Delta Virus - immunology</subject><subject>Hepatitis Delta Virus - isolation & purification</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Microbiology</subject><subject>Middle Aged</subject><subject>Miscellaneous</subject><subject>Molecular Sequence Data</subject><subject>Mongolia</subject><subject>Mongolia - epidemiology</subject><subject>Phylogeny</subject><subject>Prevalence</subject><subject>Recombinant Proteins - immunology</subject><subject>Recombinant Proteins - isolation & purification</subject><subject>RNA, Viral - blood</subject><subject>Spectrophotometry</subject><subject>Viral diseases</subject><subject>Viral hepatitis</subject><subject>Virology</subject><issn>0146-6615</issn><issn>1096-9071</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1v1DAQhi0EokvhwB9AvoDEIa0dJ3Z8RC20VFugEl83a-KddF2cD-xkIZz54XjZhZ4QJ1uj531Go5eQx5wdccby45t2c5QzIcUdsuBMy0wzxe-SBeOFzKTk5QF5EOMNY6zSeX6fHPBSs1wxtiA_z931mg4BN-Cxs0j7hq5xgNGNLtIV-hHoxoUpUtc1aEfXd2k6ph_UHmk9U-x-zC1S17ZT10OMMFNo--6awjBAwG70czKCH9dzcqzcxq0m8FsfvUxY7x08JPeaNMJH-_eQfHj18v3JebZ8e_b65MUys0VViQx5LoTgqhBK1lLXGkUJTGnegOW6tFxY2WhbV41SspArJVHwwmqd0qUSuTgkz3beIfRfJ4yjaV206D102E_RSFVJWWn9X5ArKaRWW_D5DrShjzFgY4bgWgiz4cxsuzGpG_O7m8Q-2UunusXVLbkvIwFP9wBEC74J0FkXbzlZlaXIVeKOd9w353H-90Zzcfnxz-psl3BxxO9_ExC-pJuFKs2nN2dmefr5nTy9ujIX4hfZ2LZz</recordid><startdate>200507</startdate><enddate>200507</enddate><creator>Inoue, Jun</creator><creator>Takahashi, Masaharu</creator><creator>Nishizawa, Tsutomu</creator><creator>Narantuya, Luvsanbasaryn</creator><creator>Sakuma, Mitsuru</creator><creator>Kagawa, Yasuo</creator><creator>Shimosegawa, Tooru</creator><creator>Okamoto, Hiroaki</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley-Liss</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>200507</creationdate><title>High prevalence of hepatitis delta virus infection detectable by enzyme immunoassay among apparently healthy individuals in Mongolia</title><author>Inoue, Jun ; Takahashi, Masaharu ; Nishizawa, Tsutomu ; Narantuya, Luvsanbasaryn ; Sakuma, Mitsuru ; Kagawa, Yasuo ; Shimosegawa, Tooru ; Okamoto, Hiroaki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4883-e12333174376b69b9e35a0791fac195c13c6f9cb8f77646d76e314c9948857323</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adult</topic><topic>anti-HDV antibodies</topic><topic>Base Sequence</topic><topic>Biological and medical sciences</topic><topic>Carrier State - epidemiology</topic><topic>Carrier State - virology</topic><topic>DNA, Viral - chemistry</topic><topic>ELISA</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>Epidemiology</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>HDV RNA</topic><topic>Hepatitis Antibodies - blood</topic><topic>Hepatitis B - epidemiology</topic><topic>Hepatitis B Antibodies - blood</topic><topic>Hepatitis B Core Antigens - immunology</topic><topic>Hepatitis B Surface Antigens - blood</topic><topic>Hepatitis D - epidemiology</topic><topic>Hepatitis D - immunology</topic><topic>Hepatitis delta Antigens - immunology</topic><topic>Hepatitis delta Antigens - isolation & purification</topic><topic>hepatitis delta virus</topic><topic>Hepatitis Delta Virus - genetics</topic><topic>Hepatitis Delta Virus - immunology</topic><topic>Hepatitis Delta Virus - isolation & purification</topic><topic>Human viral diseases</topic><topic>Humans</topic><topic>Infectious diseases</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Microbiology</topic><topic>Middle Aged</topic><topic>Miscellaneous</topic><topic>Molecular Sequence Data</topic><topic>Mongolia</topic><topic>Mongolia - epidemiology</topic><topic>Phylogeny</topic><topic>Prevalence</topic><topic>Recombinant Proteins - immunology</topic><topic>Recombinant Proteins - isolation & purification</topic><topic>RNA, Viral - blood</topic><topic>Spectrophotometry</topic><topic>Viral diseases</topic><topic>Viral hepatitis</topic><topic>Virology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Inoue, Jun</creatorcontrib><creatorcontrib>Takahashi, Masaharu</creatorcontrib><creatorcontrib>Nishizawa, Tsutomu</creatorcontrib><creatorcontrib>Narantuya, Luvsanbasaryn</creatorcontrib><creatorcontrib>Sakuma, Mitsuru</creatorcontrib><creatorcontrib>Kagawa, Yasuo</creatorcontrib><creatorcontrib>Shimosegawa, Tooru</creatorcontrib><creatorcontrib>Okamoto, Hiroaki</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of medical virology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Inoue, Jun</au><au>Takahashi, Masaharu</au><au>Nishizawa, Tsutomu</au><au>Narantuya, Luvsanbasaryn</au><au>Sakuma, Mitsuru</au><au>Kagawa, Yasuo</au><au>Shimosegawa, Tooru</au><au>Okamoto, Hiroaki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>High prevalence of hepatitis delta virus infection detectable by enzyme immunoassay among apparently healthy individuals in Mongolia</atitle><jtitle>Journal of medical virology</jtitle><addtitle>J. Med. Virol</addtitle><date>2005-07</date><risdate>2005</risdate><volume>76</volume><issue>3</issue><spage>333</spage><epage>340</epage><pages>333-340</pages><issn>0146-6615</issn><eissn>1096-9071</eissn><coden>JMVIDB</coden><abstract>A previous study revealed a high prevalence of hepatitis B surface antigen (HBsAg) and hepatitis delta virus (HDV) RNA among 249 apparently healthy individuals (mean ± standard deviation age, 48.4 ± 13.9 years; 126 males and 123 females) in Ulaanbaatar, Mongolia. To investigate further the prevalence of HDV infection there, the same serum samples obtained from the cohort were tested for the presence of immunoglobulin G (IgG) class antibody to HDV (anti‐HDV) by a newly developed enzyme‐linked immunosorbent assay using recombinant hepatitis delta antigen protein expressed in the pupae of silkworm as the antigen probe. Anti‐HDV was detected in 42 persons (16.9%), among whom 22 (52.4%) were positive for HBsAg and 20 (47.6%) had detectable HDV RNA. Among 170 persons with anti‐HBc in the absence of HBsAg, 20 (11.8%) tested positive for anti‐HDV, and 1 of the 20 subjects was positive for HDV RNA. Of note, none of 55 anti‐HBc‐negative persons had anti‐HDV, supporting the specificity of the anti‐HDV assay. The optical density (OD) value of anti‐HDV was significantly higher among HDV RNA‐positive subjects (n = 21) than among HDV RNA‐negative subjects (n = 21) (2.513 ± 0.514 vs. 0.836 ± 0.550, P < 0.0001). The present study confirmed the extremely high prevalence of HDV infection in Mongolia, and identified a person who was positive for both anti‐HDV and HDV RNA despite negativity for HBsAg and HBV DNA probably due to viral interference. The anti‐HDV assay may be useful for further epidemiological studies on HDV infection in larger cohorts in urban and rural areas of Mongolia, where elucidation of the transmission route of HDV is required urgently. J. Med. Virol. 76:333–340, 2005. © 2005 Wiley‐Liss, Inc.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>15902700</pmid><doi>10.1002/jmv.20363</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0146-6615 |
| ispartof | Journal of medical virology, 2005-07, Vol.76 (3), p.333-340 |
| issn | 0146-6615 1096-9071 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_67866899 |
| source | MEDLINE; Access via Wiley Online Library |
| subjects | Adult anti-HDV antibodies Base Sequence Biological and medical sciences Carrier State - epidemiology Carrier State - virology DNA, Viral - chemistry ELISA Enzyme-Linked Immunosorbent Assay Epidemiology Female Fundamental and applied biological sciences. Psychology HDV RNA Hepatitis Antibodies - blood Hepatitis B - epidemiology Hepatitis B Antibodies - blood Hepatitis B Core Antigens - immunology Hepatitis B Surface Antigens - blood Hepatitis D - epidemiology Hepatitis D - immunology Hepatitis delta Antigens - immunology Hepatitis delta Antigens - isolation & purification hepatitis delta virus Hepatitis Delta Virus - genetics Hepatitis Delta Virus - immunology Hepatitis Delta Virus - isolation & purification Human viral diseases Humans Infectious diseases Male Medical sciences Microbiology Middle Aged Miscellaneous Molecular Sequence Data Mongolia Mongolia - epidemiology Phylogeny Prevalence Recombinant Proteins - immunology Recombinant Proteins - isolation & purification RNA, Viral - blood Spectrophotometry Viral diseases Viral hepatitis Virology |
| title | High prevalence of hepatitis delta virus infection detectable by enzyme immunoassay among apparently healthy individuals in Mongolia |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-01T19%3A30%3A17IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=High%20prevalence%20of%20hepatitis%20delta%20virus%20infection%20detectable%20by%20enzyme%20immunoassay%20among%20apparently%20healthy%20individuals%20in%20Mongolia&rft.jtitle=Journal%20of%20medical%20virology&rft.au=Inoue,%20Jun&rft.date=2005-07&rft.volume=76&rft.issue=3&rft.spage=333&rft.epage=340&rft.pages=333-340&rft.issn=0146-6615&rft.eissn=1096-9071&rft.coden=JMVIDB&rft_id=info:doi/10.1002/jmv.20363&rft_dat=%3Cproquest_cross%3E17636979%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=17636979&rft_id=info:pmid/15902700&rfr_iscdi=true |