Bone morphogenetic protein 7 protects prostate cancer cells from stress-induced apoptosis via both smad and c-Jun NH2-terminal kinase pathways

We reported earlier that exposure to exogenous bone morphogenetic protein 7 (BMP7) could strongly inhibit serum starvation-induced apoptosis to C4-2B cell line, a variant of the LNCaP human prostate cancer cell line with propensity for bone metastasis. Whereas serum starvation suppressed the express...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2006-04, Vol.66 (8), p.4285-4290
Hauptverfasser:	SHANGXIN YANG, LIM, Minyoung, PHAM, Linda K, KENDALL, Stephen E, REDDI, A. Hari, ALTIERI, Dario C, ROY-BURMAN, Pradip
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic agents Apoptosis - physiology Biological and medical sciences Bone Morphogenetic Protein 7 Bone Morphogenetic Proteins - biosynthesis Bone Morphogenetic Proteins - genetics Bone Morphogenetic Proteins - pharmacology Bone Morphogenetic Proteins - physiology Cell Division Cell Line, Tumor Enzyme Activation G2 Phase Gynecology. Andrology. Obstetrics Humans Inhibitor of Apoptosis Proteins JNK Mitogen-Activated Protein Kinases - metabolism Male Male genital diseases Medical sciences Microtubule-Associated Proteins - biosynthesis Microtubule-Associated Proteins - genetics Microtubule-Associated Proteins - metabolism Neoplasm Proteins - biosynthesis Neoplasm Proteins - genetics Neoplasm Proteins - metabolism Nephrology. Urinary tract diseases Pharmacology. Drug treatments Phosphorylation Promoter Regions, Genetic Prostatic Neoplasms - enzymology Prostatic Neoplasms - genetics Prostatic Neoplasms - metabolism Prostatic Neoplasms - pathology Recombinant Proteins - biosynthesis Recombinant Proteins - genetics Recombinant Proteins - pharmacology Smad Proteins - biosynthesis Smad Proteins - genetics Smad Proteins - metabolism Tumors Tumors of the urinary system Up-Regulation Urinary tract. Prostate gland
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