Decreased circulating macrophage migration inhibitory factor (MIF) protein and blood mononuclear cell MIF transcripts in children with Plasmodium falciparum malaria
Plasmodium falciparum malaria remains one of the most frequently lethal diseases affecting children in sub-Saharan Africa, yet the immune mediators that regulate pathogenesis are only partially defined. Since macrophage migration inhibitory factor (MIF) is important for regulating innate immunity in...
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| Veröffentlicht in: | Clinical Immunology 2006-05, Vol.119 (2), p.219-225 |
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| creator | Awandare, Gordon A. Hittner, James B. Kremsner, Peter G. Ochiel, Daniel O. Keller, Christopher C. Weinberg, J. Brice Clark, Ian A. Perkins, Douglas J. |
| description | Plasmodium falciparum malaria remains one of the most frequently lethal diseases affecting children in sub-Saharan Africa, yet the immune mediators that regulate pathogenesis are only partially defined. Since macrophage migration inhibitory factor (MIF) is important for regulating innate immunity in bacterial and parasitic infections, circulating MIF and peripheral blood mononuclear cell (PBMC) MIF transcripts were investigated in children with acute falciparum malaria. Peripheral blood levels of MIF-regulatory cytokines and effector molecules, including interferon (IFN)-γ, tumor necrosis factor (TNF)-α, interleukin (IL)-12, IL-10, transforming growth factor (TGF)-β1, bicyclo-prostaglandin (PG) E
2, and nitric oxide synthase activity were also determined. Circulating MIF and PBMC MIF mRNA were significantly lower in children with acute malaria relative to healthy, malaria-exposed children. Peripheral blood MIF levels showed no association with either parasitemia or hemoglobin concentrations. Circulating MIF was, however, significantly associated with IL-12 and TGF-β1. Multiple regression analyses revealed that IFN-γ was the most significant predictor of peripheral blood MIF concentrations. These findings suggest that reduced MIF production may promote enhanced disease severity in children with falciparum malaria. |
| doi_str_mv | 10.1016/j.clim.2005.12.003 |
| format | Article |
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2, and nitric oxide synthase activity were also determined. Circulating MIF and PBMC MIF mRNA were significantly lower in children with acute malaria relative to healthy, malaria-exposed children. Peripheral blood MIF levels showed no association with either parasitemia or hemoglobin concentrations. Circulating MIF was, however, significantly associated with IL-12 and TGF-β1. Multiple regression analyses revealed that IFN-γ was the most significant predictor of peripheral blood MIF concentrations. These findings suggest that reduced MIF production may promote enhanced disease severity in children with falciparum malaria.</description><identifier>ISSN: 1521-6616</identifier><identifier>EISSN: 1521-7035</identifier><identifier>EISSN: 1365-2567</identifier><identifier>DOI: 10.1016/j.clim.2005.12.003</identifier><identifier>PMID: 16461006</identifier><identifier>CODEN: CLIIFY</identifier><language>eng</language><publisher>San Diego, CA: Elsevier Inc</publisher><subject>Anemia ; Animals ; Biological and medical sciences ; Child ; Child, Preschool ; Cytokines ; Cytokines - metabolism ; Down-Regulation - immunology ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; Humans ; Immunity ; Immunopathology ; Leukocytes, Mononuclear - immunology ; Leukocytes, Mononuclear - metabolism ; Leukocytes, Mononuclear - parasitology ; Macrophage migration inhibitory factor (MIF) ; Macrophage Migration-Inhibitory Factors - antagonists & inhibitors ; Macrophage Migration-Inhibitory Factors - biosynthesis ; Macrophage Migration-Inhibitory Factors - blood ; Macrophage Migration-Inhibitory Factors - genetics ; Malaria ; Malaria, Falciparum - blood ; Malaria, Falciparum - diagnosis ; Malaria, Falciparum - immunology ; Medical sciences ; Plasmodium falciparum ; Plasmodium falciparum - immunology ; RNA, Messenger - antagonists & inhibitors ; RNA, Messenger - biosynthesis ; RNA, Messenger - blood ; Severity of Illness Index ; Transcription, Genetic - immunology</subject><ispartof>Clinical Immunology, 2006-05, Vol.119 (2), p.219-225</ispartof><rights>2006 Elsevier Inc.</rights><rights>2006 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c415t-ae6b220420bf3725cb3946ba4338212399c3ee74447adcafd6ce65ba4219e4d23</citedby><cites>FETCH-LOGICAL-c415t-ae6b220420bf3725cb3946ba4338212399c3ee74447adcafd6ce65ba4219e4d23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.clim.2005.12.003$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3549,27923,27924,45994</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17732524$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16461006$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Awandare, Gordon A.</creatorcontrib><creatorcontrib>Hittner, James B.</creatorcontrib><creatorcontrib>Kremsner, Peter G.</creatorcontrib><creatorcontrib>Ochiel, Daniel O.</creatorcontrib><creatorcontrib>Keller, Christopher C.</creatorcontrib><creatorcontrib>Weinberg, J. Brice</creatorcontrib><creatorcontrib>Clark, Ian A.</creatorcontrib><creatorcontrib>Perkins, Douglas J.</creatorcontrib><title>Decreased circulating macrophage migration inhibitory factor (MIF) protein and blood mononuclear cell MIF transcripts in children with Plasmodium falciparum malaria</title><title>Clinical Immunology</title><addtitle>Clin Immunol</addtitle><description>Plasmodium falciparum malaria remains one of the most frequently lethal diseases affecting children in sub-Saharan Africa, yet the immune mediators that regulate pathogenesis are only partially defined. Since macrophage migration inhibitory factor (MIF) is important for regulating innate immunity in bacterial and parasitic infections, circulating MIF and peripheral blood mononuclear cell (PBMC) MIF transcripts were investigated in children with acute falciparum malaria. Peripheral blood levels of MIF-regulatory cytokines and effector molecules, including interferon (IFN)-γ, tumor necrosis factor (TNF)-α, interleukin (IL)-12, IL-10, transforming growth factor (TGF)-β1, bicyclo-prostaglandin (PG) E
2, and nitric oxide synthase activity were also determined. Circulating MIF and PBMC MIF mRNA were significantly lower in children with acute malaria relative to healthy, malaria-exposed children. Peripheral blood MIF levels showed no association with either parasitemia or hemoglobin concentrations. Circulating MIF was, however, significantly associated with IL-12 and TGF-β1. Multiple regression analyses revealed that IFN-γ was the most significant predictor of peripheral blood MIF concentrations. These findings suggest that reduced MIF production may promote enhanced disease severity in children with falciparum malaria.</description><subject>Anemia</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Cytokines</subject><subject>Cytokines - metabolism</subject><subject>Down-Regulation - immunology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fundamental immunology</subject><subject>Humans</subject><subject>Immunity</subject><subject>Immunopathology</subject><subject>Leukocytes, Mononuclear - immunology</subject><subject>Leukocytes, Mononuclear - metabolism</subject><subject>Leukocytes, Mononuclear - parasitology</subject><subject>Macrophage migration inhibitory factor (MIF)</subject><subject>Macrophage Migration-Inhibitory Factors - antagonists & inhibitors</subject><subject>Macrophage Migration-Inhibitory Factors - biosynthesis</subject><subject>Macrophage Migration-Inhibitory Factors - blood</subject><subject>Macrophage Migration-Inhibitory Factors - genetics</subject><subject>Malaria</subject><subject>Malaria, Falciparum - blood</subject><subject>Malaria, Falciparum - diagnosis</subject><subject>Malaria, Falciparum - immunology</subject><subject>Medical sciences</subject><subject>Plasmodium falciparum</subject><subject>Plasmodium falciparum - immunology</subject><subject>RNA, Messenger - antagonists & inhibitors</subject><subject>RNA, Messenger - biosynthesis</subject><subject>RNA, Messenger - blood</subject><subject>Severity of Illness Index</subject><subject>Transcription, Genetic - immunology</subject><issn>1521-6616</issn><issn>1521-7035</issn><issn>1365-2567</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkcuO1DAQRSMEYh7wAyyQNyBYdONH4nQkNmiYgZEGwQLWllOudFfLsYOdgOZ_-FDc6pZmB6sqlU9dle-tqheCrwUX-t1-DZ7GteS8WQu55lw9qs5FI8Wq5ap5fOq1Fvqsush5zwsopX5anQlda8G5Pq_-fERIaDM6BpRg8XamsGWjhRSnnd0iG2mbyjAGRmFHPc0x3bPBQqnszZfbm7dsSnFGCswGx3ofo2NjDDEs4NEmBug9Kxybkw0ZEk1zLlIMduRdwsB-07xj37zNY3S0jEXbA002lXa03iayz6onZZjx-aleVj9urr9ffV7dff10e_XhbgW1aOaVRd1LyWvJ-0G1soFedbXuba3URgqpug4UYlvXdWsd2MFpQN2Udyk6rJ1Ul9Xro2750c8F82xGyof7bcC4ZKPbjW66TfNfULSi7TatKqA8gsXOnBMOZko02nRvBDeHEM3eHEI0hxCNkKaEWJZentSXfkT3sHJKrQCvToDNYP1QjAXKD1zbKtnIunDvjxwW034RJpOBMAA6SgizcZH-dcdf9QK9vQ</recordid><startdate>20060501</startdate><enddate>20060501</enddate><creator>Awandare, Gordon A.</creator><creator>Hittner, James B.</creator><creator>Kremsner, Peter G.</creator><creator>Ochiel, Daniel O.</creator><creator>Keller, Christopher C.</creator><creator>Weinberg, J. Brice</creator><creator>Clark, Ian A.</creator><creator>Perkins, Douglas J.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7T5</scope><scope>C1K</scope><scope>H94</scope><scope>M7N</scope><scope>7X8</scope></search><sort><creationdate>20060501</creationdate><title>Decreased circulating macrophage migration inhibitory factor (MIF) protein and blood mononuclear cell MIF transcripts in children with Plasmodium falciparum malaria</title><author>Awandare, Gordon A. ; Hittner, James B. ; Kremsner, Peter G. ; Ochiel, Daniel O. ; Keller, Christopher C. ; Weinberg, J. Brice ; Clark, Ian A. ; Perkins, Douglas J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c415t-ae6b220420bf3725cb3946ba4338212399c3ee74447adcafd6ce65ba4219e4d23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Anemia</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Cytokines</topic><topic>Cytokines - metabolism</topic><topic>Down-Regulation - immunology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Fundamental immunology</topic><topic>Humans</topic><topic>Immunity</topic><topic>Immunopathology</topic><topic>Leukocytes, Mononuclear - immunology</topic><topic>Leukocytes, Mononuclear - metabolism</topic><topic>Leukocytes, Mononuclear - parasitology</topic><topic>Macrophage migration inhibitory factor (MIF)</topic><topic>Macrophage Migration-Inhibitory Factors - antagonists & inhibitors</topic><topic>Macrophage Migration-Inhibitory Factors - biosynthesis</topic><topic>Macrophage Migration-Inhibitory Factors - blood</topic><topic>Macrophage Migration-Inhibitory Factors - genetics</topic><topic>Malaria</topic><topic>Malaria, Falciparum - blood</topic><topic>Malaria, Falciparum - diagnosis</topic><topic>Malaria, Falciparum - immunology</topic><topic>Medical sciences</topic><topic>Plasmodium falciparum</topic><topic>Plasmodium falciparum - immunology</topic><topic>RNA, Messenger - antagonists & inhibitors</topic><topic>RNA, Messenger - biosynthesis</topic><topic>RNA, Messenger - blood</topic><topic>Severity of Illness Index</topic><topic>Transcription, Genetic - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Awandare, Gordon A.</creatorcontrib><creatorcontrib>Hittner, James B.</creatorcontrib><creatorcontrib>Kremsner, Peter G.</creatorcontrib><creatorcontrib>Ochiel, Daniel O.</creatorcontrib><creatorcontrib>Keller, Christopher C.</creatorcontrib><creatorcontrib>Weinberg, J. Brice</creatorcontrib><creatorcontrib>Clark, Ian A.</creatorcontrib><creatorcontrib>Perkins, Douglas J.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Immunology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical Immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Awandare, Gordon A.</au><au>Hittner, James B.</au><au>Kremsner, Peter G.</au><au>Ochiel, Daniel O.</au><au>Keller, Christopher C.</au><au>Weinberg, J. Brice</au><au>Clark, Ian A.</au><au>Perkins, Douglas J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Decreased circulating macrophage migration inhibitory factor (MIF) protein and blood mononuclear cell MIF transcripts in children with Plasmodium falciparum malaria</atitle><jtitle>Clinical Immunology</jtitle><addtitle>Clin Immunol</addtitle><date>2006-05-01</date><risdate>2006</risdate><volume>119</volume><issue>2</issue><spage>219</spage><epage>225</epage><pages>219-225</pages><issn>1521-6616</issn><eissn>1521-7035</eissn><eissn>1365-2567</eissn><coden>CLIIFY</coden><abstract>Plasmodium falciparum malaria remains one of the most frequently lethal diseases affecting children in sub-Saharan Africa, yet the immune mediators that regulate pathogenesis are only partially defined. Since macrophage migration inhibitory factor (MIF) is important for regulating innate immunity in bacterial and parasitic infections, circulating MIF and peripheral blood mononuclear cell (PBMC) MIF transcripts were investigated in children with acute falciparum malaria. Peripheral blood levels of MIF-regulatory cytokines and effector molecules, including interferon (IFN)-γ, tumor necrosis factor (TNF)-α, interleukin (IL)-12, IL-10, transforming growth factor (TGF)-β1, bicyclo-prostaglandin (PG) E
2, and nitric oxide synthase activity were also determined. Circulating MIF and PBMC MIF mRNA were significantly lower in children with acute malaria relative to healthy, malaria-exposed children. Peripheral blood MIF levels showed no association with either parasitemia or hemoglobin concentrations. Circulating MIF was, however, significantly associated with IL-12 and TGF-β1. Multiple regression analyses revealed that IFN-γ was the most significant predictor of peripheral blood MIF concentrations. These findings suggest that reduced MIF production may promote enhanced disease severity in children with falciparum malaria.</abstract><cop>San Diego, CA</cop><pub>Elsevier Inc</pub><pmid>16461006</pmid><doi>10.1016/j.clim.2005.12.003</doi><tpages>7</tpages></addata></record> |
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| subjects | Anemia Animals Biological and medical sciences Child Child, Preschool Cytokines Cytokines - metabolism Down-Regulation - immunology Fundamental and applied biological sciences. Psychology Fundamental immunology Humans Immunity Immunopathology Leukocytes, Mononuclear - immunology Leukocytes, Mononuclear - metabolism Leukocytes, Mononuclear - parasitology Macrophage migration inhibitory factor (MIF) Macrophage Migration-Inhibitory Factors - antagonists & inhibitors Macrophage Migration-Inhibitory Factors - biosynthesis Macrophage Migration-Inhibitory Factors - blood Macrophage Migration-Inhibitory Factors - genetics Malaria Malaria, Falciparum - blood Malaria, Falciparum - diagnosis Malaria, Falciparum - immunology Medical sciences Plasmodium falciparum Plasmodium falciparum - immunology RNA, Messenger - antagonists & inhibitors RNA, Messenger - biosynthesis RNA, Messenger - blood Severity of Illness Index Transcription, Genetic - immunology |
| title | Decreased circulating macrophage migration inhibitory factor (MIF) protein and blood mononuclear cell MIF transcripts in children with Plasmodium falciparum malaria |
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