Basal core-promoter mutant of hepatitis B virus and progression of liver disease in hepatitis B e antigen-negative chronic hepatitis B
Background/Aims: The long‐term outcomes in hepatitis B e antigen (HBeAg)‐negative chronic hepatitis B are distinct from those in HBeAg‐positive chronic hepatitis. However, the molecular virological factors that contribute to the progression of liver disease in this special clinical setting remain la...
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| Veröffentlicht in: | Liver international 2005-06, Vol.25 (3), p.564-570 |
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| creator | Lin, Chih-Lin Liao, Li-Ying Wang, Chaur-Shine Chen, Pei-Jer Lai, Ming-Yang Chen, Ding-Shinn Kao, Jia-Horng |
| description | Background/Aims: The long‐term outcomes in hepatitis B e antigen (HBeAg)‐negative chronic hepatitis B are distinct from those in HBeAg‐positive chronic hepatitis. However, the molecular virological factors that contribute to the progression of liver disease in this special clinical setting remain largely unknown. We thus investigated the association of hepatitis B virus (HBV) genotypes as well as precore/basal core‐promoter mutations with the clinical and virological characteristics of patients with HBeAg‐negative chronic hepatitis B in Taiwan.
Methods: HBV genotypes and sequences of precore and basal core‐promoter regions of the HBV genome were determined in 174 HBeAg‐negative chronic HBV infection patients including 62 inactive carriers and 112 with different stages of liver disease.
Results: HBV carriers with older age (>50 years) (odds ratio, 9.09; 95% confidence interval (CI), 3.22–25, P |
| doi_str_mv | 10.1111/j.1478-3231.2005.01041.x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_67865810</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>67865810</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4851-1a48cb256b9d9bb3cb0f91abce6fd044029a36306bdff5eb8791bccf7ff35c003</originalsourceid><addsrcrecordid>eNqNkc1u3CAQgFGUqEnTvkLEqTe7YIxtDj10V_mTVsmlbXpDgIcNW_9swN5sXiDPXdxdbdpbuTCC75uBGYQwJSmN6_MqpXlZJSxjNM0I4SmhJKfp9gidHS6OD3HGTtH7EFaEUCE4fYdOKRdREPkZep2poBpseg_J2vdtP4DH7TiobsC9xY-wVoMbXMAzvHF-DFh1NY7g0kMIru8mqHGbKNUugAqAXfePBdEY3BK6pINlPN0ANo--75z5G_uATqxqAnzc7-fo-9Xlt_lNsri_vp1_XSQmrzhNqMorozNeaFELrZnRxAqqtIHC1iTPSSYUKxgpdG0tB12VgmpjbGkt44YQdo4-7fLGLzyNEAbZumCgaVQH_RhkUVYFr-gEVjvQ-D4ED1auvWuVf5GUyGkGciWn9sqp1XKagfwzA7mN6sW-xqhbqN_EfdMj8GUHPLsGXv47sVzc_pii6Cc734UBtgdf-V_x_azk8uHuWt4Q-nM-e1jInP0GXXOnDg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>67865810</pqid></control><display><type>article</type><title>Basal core-promoter mutant of hepatitis B virus and progression of liver disease in hepatitis B e antigen-negative chronic hepatitis B</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Lin, Chih-Lin ; Liao, Li-Ying ; Wang, Chaur-Shine ; Chen, Pei-Jer ; Lai, Ming-Yang ; Chen, Ding-Shinn ; Kao, Jia-Horng</creator><creatorcontrib>Lin, Chih-Lin ; Liao, Li-Ying ; Wang, Chaur-Shine ; Chen, Pei-Jer ; Lai, Ming-Yang ; Chen, Ding-Shinn ; Kao, Jia-Horng</creatorcontrib><description>Background/Aims: The long‐term outcomes in hepatitis B e antigen (HBeAg)‐negative chronic hepatitis B are distinct from those in HBeAg‐positive chronic hepatitis. However, the molecular virological factors that contribute to the progression of liver disease in this special clinical setting remain largely unknown. We thus investigated the association of hepatitis B virus (HBV) genotypes as well as precore/basal core‐promoter mutations with the clinical and virological characteristics of patients with HBeAg‐negative chronic hepatitis B in Taiwan.
Methods: HBV genotypes and sequences of precore and basal core‐promoter regions of the HBV genome were determined in 174 HBeAg‐negative chronic HBV infection patients including 62 inactive carriers and 112 with different stages of liver disease.
Results: HBV carriers with older age (>50 years) (odds ratio, 9.09; 95% confidence interval (CI), 3.22–25, P<0.001) and basal core‐promoter mutant of HBV (odds ratio, 4.12; 95% CI, 1.41–12.03, P=0.01) were associated with the development of liver cirrhosis and hepatocellular carcinoma (HCC). The gender‐related risk factors associated with the development of liver cirrhosis and HCC were further analyzed, and basal core‐promoter mutant was only associated with the development of liver cirrhosis and HCC in male carriers (odds ratio, 4.35; 95% CI, 1.30–14.52, P=0.02).
Conclusions: The risk of development of liver cirrhosis and HCC is significantly increased in patients with advanced age as well as with basal core‐promoter mutant of HBV. In addition, basal core‐promoter mutant might contribute to the gender difference of the progression of liver disease in HBeAg‐negative chronic hepatitis B in Taiwan.</description><identifier>ISSN: 1478-3223</identifier><identifier>EISSN: 1478-3231</identifier><identifier>DOI: 10.1111/j.1478-3231.2005.01041.x</identifier><identifier>PMID: 15910494</identifier><language>eng</language><publisher>Oxford, UK: Munksgaard International Publishers</publisher><subject>Adult ; Age Distribution ; Aged ; basal core promoter ; Carrier State - virology ; chronic hepatitis B ; Disease Progression ; Female ; Genotype ; Hepatitis B e Antigens - genetics ; hepatitis B genotype ; Hepatitis B virus - genetics ; hepatitis B virus mutant ; Hepatitis B, Chronic - epidemiology ; Hepatitis B, Chronic - physiopathology ; Hepatitis B, Chronic - virology ; hepatitis e antigen ; hepatocellular carcinoma ; Humans ; liver cirrhosis ; Liver Cirrhosis - epidemiology ; Liver Cirrhosis - physiopathology ; Liver Cirrhosis - virology ; Male ; Middle Aged ; Promoter Regions, Genetic - genetics ; Risk Factors ; Sex Distribution ; Taiwan - epidemiology</subject><ispartof>Liver international, 2005-06, Vol.25 (3), p.564-570</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4851-1a48cb256b9d9bb3cb0f91abce6fd044029a36306bdff5eb8791bccf7ff35c003</citedby><cites>FETCH-LOGICAL-c4851-1a48cb256b9d9bb3cb0f91abce6fd044029a36306bdff5eb8791bccf7ff35c003</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1478-3231.2005.01041.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1478-3231.2005.01041.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15910494$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lin, Chih-Lin</creatorcontrib><creatorcontrib>Liao, Li-Ying</creatorcontrib><creatorcontrib>Wang, Chaur-Shine</creatorcontrib><creatorcontrib>Chen, Pei-Jer</creatorcontrib><creatorcontrib>Lai, Ming-Yang</creatorcontrib><creatorcontrib>Chen, Ding-Shinn</creatorcontrib><creatorcontrib>Kao, Jia-Horng</creatorcontrib><title>Basal core-promoter mutant of hepatitis B virus and progression of liver disease in hepatitis B e antigen-negative chronic hepatitis B</title><title>Liver international</title><addtitle>Liver Int</addtitle><description>Background/Aims: The long‐term outcomes in hepatitis B e antigen (HBeAg)‐negative chronic hepatitis B are distinct from those in HBeAg‐positive chronic hepatitis. However, the molecular virological factors that contribute to the progression of liver disease in this special clinical setting remain largely unknown. We thus investigated the association of hepatitis B virus (HBV) genotypes as well as precore/basal core‐promoter mutations with the clinical and virological characteristics of patients with HBeAg‐negative chronic hepatitis B in Taiwan.
Methods: HBV genotypes and sequences of precore and basal core‐promoter regions of the HBV genome were determined in 174 HBeAg‐negative chronic HBV infection patients including 62 inactive carriers and 112 with different stages of liver disease.
Results: HBV carriers with older age (>50 years) (odds ratio, 9.09; 95% confidence interval (CI), 3.22–25, P<0.001) and basal core‐promoter mutant of HBV (odds ratio, 4.12; 95% CI, 1.41–12.03, P=0.01) were associated with the development of liver cirrhosis and hepatocellular carcinoma (HCC). The gender‐related risk factors associated with the development of liver cirrhosis and HCC were further analyzed, and basal core‐promoter mutant was only associated with the development of liver cirrhosis and HCC in male carriers (odds ratio, 4.35; 95% CI, 1.30–14.52, P=0.02).
Conclusions: The risk of development of liver cirrhosis and HCC is significantly increased in patients with advanced age as well as with basal core‐promoter mutant of HBV. In addition, basal core‐promoter mutant might contribute to the gender difference of the progression of liver disease in HBeAg‐negative chronic hepatitis B in Taiwan.</description><subject>Adult</subject><subject>Age Distribution</subject><subject>Aged</subject><subject>basal core promoter</subject><subject>Carrier State - virology</subject><subject>chronic hepatitis B</subject><subject>Disease Progression</subject><subject>Female</subject><subject>Genotype</subject><subject>Hepatitis B e Antigens - genetics</subject><subject>hepatitis B genotype</subject><subject>Hepatitis B virus - genetics</subject><subject>hepatitis B virus mutant</subject><subject>Hepatitis B, Chronic - epidemiology</subject><subject>Hepatitis B, Chronic - physiopathology</subject><subject>Hepatitis B, Chronic - virology</subject><subject>hepatitis e antigen</subject><subject>hepatocellular carcinoma</subject><subject>Humans</subject><subject>liver cirrhosis</subject><subject>Liver Cirrhosis - epidemiology</subject><subject>Liver Cirrhosis - physiopathology</subject><subject>Liver Cirrhosis - virology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Promoter Regions, Genetic - genetics</subject><subject>Risk Factors</subject><subject>Sex Distribution</subject><subject>Taiwan - epidemiology</subject><issn>1478-3223</issn><issn>1478-3231</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkc1u3CAQgFGUqEnTvkLEqTe7YIxtDj10V_mTVsmlbXpDgIcNW_9swN5sXiDPXdxdbdpbuTCC75uBGYQwJSmN6_MqpXlZJSxjNM0I4SmhJKfp9gidHS6OD3HGTtH7EFaEUCE4fYdOKRdREPkZep2poBpseg_J2vdtP4DH7TiobsC9xY-wVoMbXMAzvHF-DFh1NY7g0kMIru8mqHGbKNUugAqAXfePBdEY3BK6pINlPN0ANo--75z5G_uATqxqAnzc7-fo-9Xlt_lNsri_vp1_XSQmrzhNqMorozNeaFELrZnRxAqqtIHC1iTPSSYUKxgpdG0tB12VgmpjbGkt44YQdo4-7fLGLzyNEAbZumCgaVQH_RhkUVYFr-gEVjvQ-D4ED1auvWuVf5GUyGkGciWn9sqp1XKagfwzA7mN6sW-xqhbqN_EfdMj8GUHPLsGXv47sVzc_pii6Cc734UBtgdf-V_x_azk8uHuWt4Q-nM-e1jInP0GXXOnDg</recordid><startdate>200506</startdate><enddate>200506</enddate><creator>Lin, Chih-Lin</creator><creator>Liao, Li-Ying</creator><creator>Wang, Chaur-Shine</creator><creator>Chen, Pei-Jer</creator><creator>Lai, Ming-Yang</creator><creator>Chen, Ding-Shinn</creator><creator>Kao, Jia-Horng</creator><general>Munksgaard International Publishers</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200506</creationdate><title>Basal core-promoter mutant of hepatitis B virus and progression of liver disease in hepatitis B e antigen-negative chronic hepatitis B</title><author>Lin, Chih-Lin ; Liao, Li-Ying ; Wang, Chaur-Shine ; Chen, Pei-Jer ; Lai, Ming-Yang ; Chen, Ding-Shinn ; Kao, Jia-Horng</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4851-1a48cb256b9d9bb3cb0f91abce6fd044029a36306bdff5eb8791bccf7ff35c003</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adult</topic><topic>Age Distribution</topic><topic>Aged</topic><topic>basal core promoter</topic><topic>Carrier State - virology</topic><topic>chronic hepatitis B</topic><topic>Disease Progression</topic><topic>Female</topic><topic>Genotype</topic><topic>Hepatitis B e Antigens - genetics</topic><topic>hepatitis B genotype</topic><topic>Hepatitis B virus - genetics</topic><topic>hepatitis B virus mutant</topic><topic>Hepatitis B, Chronic - epidemiology</topic><topic>Hepatitis B, Chronic - physiopathology</topic><topic>Hepatitis B, Chronic - virology</topic><topic>hepatitis e antigen</topic><topic>hepatocellular carcinoma</topic><topic>Humans</topic><topic>liver cirrhosis</topic><topic>Liver Cirrhosis - epidemiology</topic><topic>Liver Cirrhosis - physiopathology</topic><topic>Liver Cirrhosis - virology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Promoter Regions, Genetic - genetics</topic><topic>Risk Factors</topic><topic>Sex Distribution</topic><topic>Taiwan - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lin, Chih-Lin</creatorcontrib><creatorcontrib>Liao, Li-Ying</creatorcontrib><creatorcontrib>Wang, Chaur-Shine</creatorcontrib><creatorcontrib>Chen, Pei-Jer</creatorcontrib><creatorcontrib>Lai, Ming-Yang</creatorcontrib><creatorcontrib>Chen, Ding-Shinn</creatorcontrib><creatorcontrib>Kao, Jia-Horng</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Liver international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lin, Chih-Lin</au><au>Liao, Li-Ying</au><au>Wang, Chaur-Shine</au><au>Chen, Pei-Jer</au><au>Lai, Ming-Yang</au><au>Chen, Ding-Shinn</au><au>Kao, Jia-Horng</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Basal core-promoter mutant of hepatitis B virus and progression of liver disease in hepatitis B e antigen-negative chronic hepatitis B</atitle><jtitle>Liver international</jtitle><addtitle>Liver Int</addtitle><date>2005-06</date><risdate>2005</risdate><volume>25</volume><issue>3</issue><spage>564</spage><epage>570</epage><pages>564-570</pages><issn>1478-3223</issn><eissn>1478-3231</eissn><abstract>Background/Aims: The long‐term outcomes in hepatitis B e antigen (HBeAg)‐negative chronic hepatitis B are distinct from those in HBeAg‐positive chronic hepatitis. However, the molecular virological factors that contribute to the progression of liver disease in this special clinical setting remain largely unknown. We thus investigated the association of hepatitis B virus (HBV) genotypes as well as precore/basal core‐promoter mutations with the clinical and virological characteristics of patients with HBeAg‐negative chronic hepatitis B in Taiwan.
Methods: HBV genotypes and sequences of precore and basal core‐promoter regions of the HBV genome were determined in 174 HBeAg‐negative chronic HBV infection patients including 62 inactive carriers and 112 with different stages of liver disease.
Results: HBV carriers with older age (>50 years) (odds ratio, 9.09; 95% confidence interval (CI), 3.22–25, P<0.001) and basal core‐promoter mutant of HBV (odds ratio, 4.12; 95% CI, 1.41–12.03, P=0.01) were associated with the development of liver cirrhosis and hepatocellular carcinoma (HCC). The gender‐related risk factors associated with the development of liver cirrhosis and HCC were further analyzed, and basal core‐promoter mutant was only associated with the development of liver cirrhosis and HCC in male carriers (odds ratio, 4.35; 95% CI, 1.30–14.52, P=0.02).
Conclusions: The risk of development of liver cirrhosis and HCC is significantly increased in patients with advanced age as well as with basal core‐promoter mutant of HBV. In addition, basal core‐promoter mutant might contribute to the gender difference of the progression of liver disease in HBeAg‐negative chronic hepatitis B in Taiwan.</abstract><cop>Oxford, UK</cop><pub>Munksgaard International Publishers</pub><pmid>15910494</pmid><doi>10.1111/j.1478-3231.2005.01041.x</doi><tpages>7</tpages></addata></record> |
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| ispartof | Liver international, 2005-06, Vol.25 (3), p.564-570 |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Adult Age Distribution Aged basal core promoter Carrier State - virology chronic hepatitis B Disease Progression Female Genotype Hepatitis B e Antigens - genetics hepatitis B genotype Hepatitis B virus - genetics hepatitis B virus mutant Hepatitis B, Chronic - epidemiology Hepatitis B, Chronic - physiopathology Hepatitis B, Chronic - virology hepatitis e antigen hepatocellular carcinoma Humans liver cirrhosis Liver Cirrhosis - epidemiology Liver Cirrhosis - physiopathology Liver Cirrhosis - virology Male Middle Aged Promoter Regions, Genetic - genetics Risk Factors Sex Distribution Taiwan - epidemiology |
| title | Basal core-promoter mutant of hepatitis B virus and progression of liver disease in hepatitis B e antigen-negative chronic hepatitis B |
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