Optimization of the separation of some psychotropic drugs and their respective metabolites by liquid chromatography
A chemometric procedure is described to optimize the separation of some drugs used in the treatment of psychotic disorders: haloperidol, levomepromazine, risperidone, venlafaxine, carbamazepine and their main metabolites: reduced haloperidol, 9-hydroxy risperidone, desmethyl levomepromazine, desmeth...
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| Veröffentlicht in: | Journal of pharmaceutical and biomedical analysis 2006-05, Vol.41 (2), p.333-340 |
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| container_title | Journal of pharmaceutical and biomedical analysis |
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| creator | Cutroneo, P. Beljean, M. Luu, R. Phan Tan Siouffi, A.-M. |
| description | A chemometric procedure is described to optimize the separation of some drugs used in the treatment of psychotic disorders: haloperidol, levomepromazine, risperidone, venlafaxine, carbamazepine and their main metabolites: reduced haloperidol, 9-hydroxy risperidone, desmethyl levomepromazine, desmethyl venlafaxine. The purpose of the procedure is the unambiguous identification and detection in biological fluids. Isocratic reversed-phase liquid chromatography with diode array detection was utilized. An experimental design methodology was carried out in which the experimental response is selectivity. In this way the designs for mixture compounds and for process variables (five variables) was performed which produced 36 experiments to carry out. The desirability function was used to select optimum separation conditions. The procedure provides a chromatogram of well separated solutes. |
| doi_str_mv | 10.1016/j.jpba.2005.10.050 |
| format | Article |
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Phan Tan</creatorcontrib><creatorcontrib>Siouffi, A.-M.</creatorcontrib><title>Optimization of the separation of some psychotropic drugs and their respective metabolites by liquid chromatography</title><title>Journal of pharmaceutical and biomedical analysis</title><addtitle>J Pharm Biomed Anal</addtitle><description>A chemometric procedure is described to optimize the separation of some drugs used in the treatment of psychotic disorders: haloperidol, levomepromazine, risperidone, venlafaxine, carbamazepine and their main metabolites: reduced haloperidol, 9-hydroxy risperidone, desmethyl levomepromazine, desmethyl venlafaxine. The purpose of the procedure is the unambiguous identification and detection in biological fluids. Isocratic reversed-phase liquid chromatography with diode array detection was utilized. An experimental design methodology was carried out in which the experimental response is selectivity. In this way the designs for mixture compounds and for process variables (five variables) was performed which produced 36 experiments to carry out. The desirability function was used to select optimum separation conditions. The procedure provides a chromatogram of well separated solutes.</description><subject>Acetonitriles - chemistry</subject><subject>Analysis</subject><subject>Analytical, structural and metabolic biochemistry</subject><subject>Biological and medical sciences</subject><subject>Buffers</subject><subject>Chemometrics</subject><subject>Chromatography, High Pressure Liquid - methods</subject><subject>Cyclohexanols - analysis</subject><subject>Desirability</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>General pharmacology</subject><subject>Haloperidol - analysis</subject><subject>Hydrogen-Ion Concentration</subject><subject>Liquid chromatography</subject><subject>Medical sciences</subject><subject>Methanol - chemistry</subject><subject>Models, Theoretical</subject><subject>Pharmacology. Drug treatments</subject><subject>Psychotropic drugs</subject><subject>Psychotropic Drugs - analysis</subject><subject>Psychotropic Drugs - metabolism</subject><subject>Risperidone - analysis</subject><subject>Solvents - chemistry</subject><subject>Time Factors</subject><subject>Venlafaxine Hydrochloride</subject><issn>0731-7085</issn><issn>1873-264X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1r3DAQhkVpabZp_0APRZf25q0ky7INvZTQLwjk0kJvQpbGWS22pWjkwPbXV2aX5tbTwDvPDDMPIW8523PG1cfj_hgHsxeMNSXYs4Y9IzvetXUllPz9nOxYW_OqZV1zRV4hHlkBeS9fkiuuJFNSqh3Bu5j97P-Y7MNCw0jzAShCNOlfgmEGGvFkDyGnEL2lLq33SM3iNtonmgAj2Owfgc6QzRAmnwHpcKKTf1i9o_aQwmxyuE8mHk6vyYvRTAhvLvWa_Pr65efN9-r27tuPm8-3la07mSvlRjG4mptu6EHIXrgeXOm0o5SdBKFqoVwjDStvSj5IOzrRKWfADG4cbF9fkw_nvTGFhxUw69mjhWkyC4QVtWo71ci-LaA4gzYFxASjjsnPJp00Z3pTrY96U6031VtWVJehd5ft6zCDexq5uC3A-wtg0JppTGaxHp-4tmVcdtuZn84cFBePHpJG62Gx4HwqVrUL_n93_AUhpqAM</recordid><startdate>20060503</startdate><enddate>20060503</enddate><creator>Cutroneo, P.</creator><creator>Beljean, M.</creator><creator>Luu, R. 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Phan Tan ; Siouffi, A.-M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c384t-6df2bd31a8b9e2492d9ed3847f4484e26326d54a007341b4cfd286daeabdfbc93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Acetonitriles - chemistry</topic><topic>Analysis</topic><topic>Analytical, structural and metabolic biochemistry</topic><topic>Biological and medical sciences</topic><topic>Buffers</topic><topic>Chemometrics</topic><topic>Chromatography, High Pressure Liquid - methods</topic><topic>Cyclohexanols - analysis</topic><topic>Desirability</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>General pharmacology</topic><topic>Haloperidol - analysis</topic><topic>Hydrogen-Ion Concentration</topic><topic>Liquid chromatography</topic><topic>Medical sciences</topic><topic>Methanol - chemistry</topic><topic>Models, Theoretical</topic><topic>Pharmacology. Drug treatments</topic><topic>Psychotropic drugs</topic><topic>Psychotropic Drugs - analysis</topic><topic>Psychotropic Drugs - metabolism</topic><topic>Risperidone - analysis</topic><topic>Solvents - chemistry</topic><topic>Time Factors</topic><topic>Venlafaxine Hydrochloride</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cutroneo, P.</creatorcontrib><creatorcontrib>Beljean, M.</creatorcontrib><creatorcontrib>Luu, R. 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Phan Tan</au><au>Siouffi, A.-M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Optimization of the separation of some psychotropic drugs and their respective metabolites by liquid chromatography</atitle><jtitle>Journal of pharmaceutical and biomedical analysis</jtitle><addtitle>J Pharm Biomed Anal</addtitle><date>2006-05-03</date><risdate>2006</risdate><volume>41</volume><issue>2</issue><spage>333</spage><epage>340</epage><pages>333-340</pages><issn>0731-7085</issn><eissn>1873-264X</eissn><coden>JPBADA</coden><abstract>A chemometric procedure is described to optimize the separation of some drugs used in the treatment of psychotic disorders: haloperidol, levomepromazine, risperidone, venlafaxine, carbamazepine and their main metabolites: reduced haloperidol, 9-hydroxy risperidone, desmethyl levomepromazine, desmethyl venlafaxine. The purpose of the procedure is the unambiguous identification and detection in biological fluids. 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| ispartof | Journal of pharmaceutical and biomedical analysis, 2006-05, Vol.41 (2), p.333-340 |
| issn | 0731-7085 1873-264X |
| language | eng |
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| subjects | Acetonitriles - chemistry Analysis Analytical, structural and metabolic biochemistry Biological and medical sciences Buffers Chemometrics Chromatography, High Pressure Liquid - methods Cyclohexanols - analysis Desirability Fundamental and applied biological sciences. Psychology General pharmacology Haloperidol - analysis Hydrogen-Ion Concentration Liquid chromatography Medical sciences Methanol - chemistry Models, Theoretical Pharmacology. Drug treatments Psychotropic drugs Psychotropic Drugs - analysis Psychotropic Drugs - metabolism Risperidone - analysis Solvents - chemistry Time Factors Venlafaxine Hydrochloride |
| title | Optimization of the separation of some psychotropic drugs and their respective metabolites by liquid chromatography |
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