Capillary deposition of complement C4d and C3d in pediatric renal allograft biopsies
Peritubular capillary deposition of C4d (C4d(PTC)) is a marker of antibody-mediated alloresponse and is associated with poor graft survival in adults. C3d(PTC) has received less attention; its significance is unclear. To date no information has been gained in children. The prevalence of C4d(PTC) and...
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| Veröffentlicht in: | Transplantation 2005-05, Vol.79 (10), p.1435-1440 |
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| creator | HERMAN, Jean LERUT, Evelyne VAN DAMME-LOMBAERTS, Rita EMONDS, Marie-Paule VAN DAMME, Boudewijn |
| description | Peritubular capillary deposition of C4d (C4d(PTC)) is a marker of antibody-mediated alloresponse and is associated with poor graft survival in adults. C3d(PTC) has received less attention; its significance is unclear. To date no information has been gained in children.
The prevalence of C4d(PTC) and C3d(PTC) in pediatric renal allograft biopsies (n=77, 31 cadaveric kidneys) was analyzed retrospectively. Associations with histology, donor-specific antibodies (DSAs), and outcome were investigated.
The overall prevalence of C4d(PTC) and C3d(PTC) was 52% and 48%, respectively. C3d(PTC) was associated with C4d(PTC) (P6 months posttransplantation) had features of chronic allograft nephropathy: 50% were C4d(PTC_ positive, and 50% were C3d(PTC) positive. C4d(PTC) positive chronic allograft nephropathy biopsies had more transplant glomerulopathy (P=0.020) and mesangial matrix increase (P=0.026). C3d(PTC) tended to be associated with transplant glomerulopathy (P=0.06), but not with mesangial matrix increase. C4d(PTC) was correlated with DSA (P=0.011). Excluding early nonrejection graft losses, more grafts were lost in the C4d(PTC) positive group (P=0.019). C3d(PTC) was not associated with DSA or graft outcome.
Our results support C4d(PTC) being a hallmark of humoral rejection in pediatric renal transplantation; its presence was associated with DSA and poorer immunologic graft outcome. In contrast, C3d(PTC), although highly associated with C4d(PTC), did not correlate with DSA or outcome. |
| doi_str_mv | 10.1097/01.TP.0000158420.26623.0F |
| format | Article |
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The prevalence of C4d(PTC) and C3d(PTC) in pediatric renal allograft biopsies (n=77, 31 cadaveric kidneys) was analyzed retrospectively. Associations with histology, donor-specific antibodies (DSAs), and outcome were investigated.
The overall prevalence of C4d(PTC) and C3d(PTC) was 52% and 48%, respectively. C3d(PTC) was associated with C4d(PTC) (P<0.0001). Thirty-six percent of acute rejections were cellular, 28% were humoral, and 36% were combined cellular and humoral. C3d(PTC) was found in 57% of acute rejection biopsies. C4d(PTC), but not C3d(PTC), was associated with accumulation of polymorphonuclear cells in peritubular capillaries (P=0.02). Fifty-one percent of late biopsies (>6 months posttransplantation) had features of chronic allograft nephropathy: 50% were C4d(PTC_ positive, and 50% were C3d(PTC) positive. C4d(PTC) positive chronic allograft nephropathy biopsies had more transplant glomerulopathy (P=0.020) and mesangial matrix increase (P=0.026). C3d(PTC) tended to be associated with transplant glomerulopathy (P=0.06), but not with mesangial matrix increase. C4d(PTC) was correlated with DSA (P=0.011). Excluding early nonrejection graft losses, more grafts were lost in the C4d(PTC) positive group (P=0.019). C3d(PTC) was not associated with DSA or graft outcome.
Our results support C4d(PTC) being a hallmark of humoral rejection in pediatric renal transplantation; its presence was associated with DSA and poorer immunologic graft outcome. In contrast, C3d(PTC), although highly associated with C4d(PTC), did not correlate with DSA or outcome.</description><identifier>ISSN: 0041-1337</identifier><identifier>EISSN: 1534-6080</identifier><identifier>DOI: 10.1097/01.TP.0000158420.26623.0F</identifier><identifier>PMID: 15912116</identifier><identifier>CODEN: TRPLAU</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott</publisher><subject>Adolescent ; Biological and medical sciences ; Biopsy ; Capillaries - metabolism ; Child ; Chronic Disease ; Complement C3d - metabolism ; Complement C4b - metabolism ; Female ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; Graft Rejection - blood ; Graft Rejection - metabolism ; Humans ; Isoantibodies - blood ; Kidney - pathology ; Kidney Diseases - etiology ; Kidney Diseases - pathology ; Kidney Transplantation - adverse effects ; Kidney Transplantation - immunology ; Kidney Tubules - blood supply ; Male ; Medical sciences ; Peptide Fragments - metabolism ; Postoperative Period ; Retrospective Studies ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Tissue Donors ; Tissue, organ and graft immunology ; Transplantation, Homologous ; Transplants ; Treatment Outcome</subject><ispartof>Transplantation, 2005-05, Vol.79 (10), p.1435-1440</ispartof><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c427t-a463b1445f0c17cf15439083cedb6090612b3db5bdf5072e73b2a29a9e5348673</citedby><cites>FETCH-LOGICAL-c427t-a463b1445f0c17cf15439083cedb6090612b3db5bdf5072e73b2a29a9e5348673</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16826248$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15912116$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>HERMAN, Jean</creatorcontrib><creatorcontrib>LERUT, Evelyne</creatorcontrib><creatorcontrib>VAN DAMME-LOMBAERTS, Rita</creatorcontrib><creatorcontrib>EMONDS, Marie-Paule</creatorcontrib><creatorcontrib>VAN DAMME, Boudewijn</creatorcontrib><title>Capillary deposition of complement C4d and C3d in pediatric renal allograft biopsies</title><title>Transplantation</title><addtitle>Transplantation</addtitle><description>Peritubular capillary deposition of C4d (C4d(PTC)) is a marker of antibody-mediated alloresponse and is associated with poor graft survival in adults. C3d(PTC) has received less attention; its significance is unclear. To date no information has been gained in children.
The prevalence of C4d(PTC) and C3d(PTC) in pediatric renal allograft biopsies (n=77, 31 cadaveric kidneys) was analyzed retrospectively. Associations with histology, donor-specific antibodies (DSAs), and outcome were investigated.
The overall prevalence of C4d(PTC) and C3d(PTC) was 52% and 48%, respectively. C3d(PTC) was associated with C4d(PTC) (P<0.0001). Thirty-six percent of acute rejections were cellular, 28% were humoral, and 36% were combined cellular and humoral. C3d(PTC) was found in 57% of acute rejection biopsies. C4d(PTC), but not C3d(PTC), was associated with accumulation of polymorphonuclear cells in peritubular capillaries (P=0.02). Fifty-one percent of late biopsies (>6 months posttransplantation) had features of chronic allograft nephropathy: 50% were C4d(PTC_ positive, and 50% were C3d(PTC) positive. C4d(PTC) positive chronic allograft nephropathy biopsies had more transplant glomerulopathy (P=0.020) and mesangial matrix increase (P=0.026). C3d(PTC) tended to be associated with transplant glomerulopathy (P=0.06), but not with mesangial matrix increase. C4d(PTC) was correlated with DSA (P=0.011). Excluding early nonrejection graft losses, more grafts were lost in the C4d(PTC) positive group (P=0.019). C3d(PTC) was not associated with DSA or graft outcome.
Our results support C4d(PTC) being a hallmark of humoral rejection in pediatric renal transplantation; its presence was associated with DSA and poorer immunologic graft outcome. In contrast, C3d(PTC), although highly associated with C4d(PTC), did not correlate with DSA or outcome.</description><subject>Adolescent</subject><subject>Biological and medical sciences</subject><subject>Biopsy</subject><subject>Capillaries - metabolism</subject><subject>Child</subject><subject>Chronic Disease</subject><subject>Complement C3d - metabolism</subject><subject>Complement C4b - metabolism</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fundamental immunology</subject><subject>Graft Rejection - blood</subject><subject>Graft Rejection - metabolism</subject><subject>Humans</subject><subject>Isoantibodies - blood</subject><subject>Kidney - pathology</subject><subject>Kidney Diseases - etiology</subject><subject>Kidney Diseases - pathology</subject><subject>Kidney Transplantation - adverse effects</subject><subject>Kidney Transplantation - immunology</subject><subject>Kidney Tubules - blood supply</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Peptide Fragments - metabolism</subject><subject>Postoperative Period</subject><subject>Retrospective Studies</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Tissue Donors</subject><subject>Tissue, organ and graft immunology</subject><subject>Transplantation, Homologous</subject><subject>Transplants</subject><subject>Treatment Outcome</subject><issn>0041-1337</issn><issn>1534-6080</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkD2P1DAQhi0E4vYO_gIyBXQJM_6MSxSxcNJJXLHUlmM7yCiJg50t-PfkuJW2ZJppnndG70PIe4QWwehPgO3psYV9UHaCQcuUYryF4wtyQMlFo6CDl-QAILBBzvUNua31185LrvVrcoPSIENUB3Lq3ZqmyZU_NMQ117SlvNA8Up_ndYpzXDbai0DdEmjPA00LXWNIbivJ0xIXN1E3TflnceNGh5TXmmJ9Q16Nbqrx7WXfkR_HL6f-W_Pw_et9__mh8YLprXFC8QGFkCN41H5EKbiBjvsYBgUGFLKBh0EOYZSgWdR8YI4ZZ-LesVOa35GPz3fXkn-fY93snKqPe50l5nO1SndKMjD_BVELo5l5As0z6EuutcTRriXNux2LYJ_cW0B7erRX9_afewvHPfvu8uQ8zDFckxfZO_DhArjq3TQWt_hUr5zqmGKi438BA-uLnA</recordid><startdate>20050527</startdate><enddate>20050527</enddate><creator>HERMAN, Jean</creator><creator>LERUT, Evelyne</creator><creator>VAN DAMME-LOMBAERTS, Rita</creator><creator>EMONDS, Marie-Paule</creator><creator>VAN DAMME, Boudewijn</creator><general>Lippincott</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20050527</creationdate><title>Capillary deposition of complement C4d and C3d in pediatric renal allograft biopsies</title><author>HERMAN, Jean ; LERUT, Evelyne ; VAN DAMME-LOMBAERTS, Rita ; EMONDS, Marie-Paule ; VAN DAMME, Boudewijn</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c427t-a463b1445f0c17cf15439083cedb6090612b3db5bdf5072e73b2a29a9e5348673</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adolescent</topic><topic>Biological and medical sciences</topic><topic>Biopsy</topic><topic>Capillaries - metabolism</topic><topic>Child</topic><topic>Chronic Disease</topic><topic>Complement C3d - metabolism</topic><topic>Complement C4b - metabolism</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Fundamental immunology</topic><topic>Graft Rejection - blood</topic><topic>Graft Rejection - metabolism</topic><topic>Humans</topic><topic>Isoantibodies - blood</topic><topic>Kidney - pathology</topic><topic>Kidney Diseases - etiology</topic><topic>Kidney Diseases - pathology</topic><topic>Kidney Transplantation - adverse effects</topic><topic>Kidney Transplantation - immunology</topic><topic>Kidney Tubules - blood supply</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Peptide Fragments - metabolism</topic><topic>Postoperative Period</topic><topic>Retrospective Studies</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Tissue Donors</topic><topic>Tissue, organ and graft immunology</topic><topic>Transplantation, Homologous</topic><topic>Transplants</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>HERMAN, Jean</creatorcontrib><creatorcontrib>LERUT, Evelyne</creatorcontrib><creatorcontrib>VAN DAMME-LOMBAERTS, Rita</creatorcontrib><creatorcontrib>EMONDS, Marie-Paule</creatorcontrib><creatorcontrib>VAN DAMME, Boudewijn</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Transplantation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>HERMAN, Jean</au><au>LERUT, Evelyne</au><au>VAN DAMME-LOMBAERTS, Rita</au><au>EMONDS, Marie-Paule</au><au>VAN DAMME, Boudewijn</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Capillary deposition of complement C4d and C3d in pediatric renal allograft biopsies</atitle><jtitle>Transplantation</jtitle><addtitle>Transplantation</addtitle><date>2005-05-27</date><risdate>2005</risdate><volume>79</volume><issue>10</issue><spage>1435</spage><epage>1440</epage><pages>1435-1440</pages><issn>0041-1337</issn><eissn>1534-6080</eissn><coden>TRPLAU</coden><abstract>Peritubular capillary deposition of C4d (C4d(PTC)) is a marker of antibody-mediated alloresponse and is associated with poor graft survival in adults. C3d(PTC) has received less attention; its significance is unclear. To date no information has been gained in children.
The prevalence of C4d(PTC) and C3d(PTC) in pediatric renal allograft biopsies (n=77, 31 cadaveric kidneys) was analyzed retrospectively. Associations with histology, donor-specific antibodies (DSAs), and outcome were investigated.
The overall prevalence of C4d(PTC) and C3d(PTC) was 52% and 48%, respectively. C3d(PTC) was associated with C4d(PTC) (P<0.0001). Thirty-six percent of acute rejections were cellular, 28% were humoral, and 36% were combined cellular and humoral. C3d(PTC) was found in 57% of acute rejection biopsies. C4d(PTC), but not C3d(PTC), was associated with accumulation of polymorphonuclear cells in peritubular capillaries (P=0.02). Fifty-one percent of late biopsies (>6 months posttransplantation) had features of chronic allograft nephropathy: 50% were C4d(PTC_ positive, and 50% were C3d(PTC) positive. C4d(PTC) positive chronic allograft nephropathy biopsies had more transplant glomerulopathy (P=0.020) and mesangial matrix increase (P=0.026). C3d(PTC) tended to be associated with transplant glomerulopathy (P=0.06), but not with mesangial matrix increase. C4d(PTC) was correlated with DSA (P=0.011). Excluding early nonrejection graft losses, more grafts were lost in the C4d(PTC) positive group (P=0.019). C3d(PTC) was not associated with DSA or graft outcome.
Our results support C4d(PTC) being a hallmark of humoral rejection in pediatric renal transplantation; its presence was associated with DSA and poorer immunologic graft outcome. In contrast, C3d(PTC), although highly associated with C4d(PTC), did not correlate with DSA or outcome.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott</pub><pmid>15912116</pmid><doi>10.1097/01.TP.0000158420.26623.0F</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Biological and medical sciences Biopsy Capillaries - metabolism Child Chronic Disease Complement C3d - metabolism Complement C4b - metabolism Female Fundamental and applied biological sciences. Psychology Fundamental immunology Graft Rejection - blood Graft Rejection - metabolism Humans Isoantibodies - blood Kidney - pathology Kidney Diseases - etiology Kidney Diseases - pathology Kidney Transplantation - adverse effects Kidney Transplantation - immunology Kidney Tubules - blood supply Male Medical sciences Peptide Fragments - metabolism Postoperative Period Retrospective Studies Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Tissue Donors Tissue, organ and graft immunology Transplantation, Homologous Transplants Treatment Outcome |
| title | Capillary deposition of complement C4d and C3d in pediatric renal allograft biopsies |
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