Components of the REST/CoREST/Histone Deacetylase Repressor Complex Are Disrupted, Modified, and Translocated in HSV-1-Infected Cells

The infected cell protein (ICP)0 enables gene expression and the replication of herpes simplex virus (HSV)-1 in cells infected at low multiplicities and enhances the expression of genes introduced into cells by transfection or infection. We report that a short sequence of ICP0 is similar to a sequen...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2005-05, Vol.102 (21), p.7571-7576
Hauptverfasser:	Gu, Haidong, Liang, Yu, Mandel, Gail, Roizman, Bernard
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological Sciences Cell Fractionation Cell Line Cell lines Cell nucleus Cellular biology Co-Repressor Proteins Cytoplasm DNA-Binding Proteins - metabolism DNA-Binding Proteins - physiology Gels Gene expression Gene Expression Regulation, Viral HeLa cells Herpes viruses Herpesvirus 1, Human Histone Deacetylase 1 Histone Deacetylases - metabolism Histone Deacetylases - physiology Human herpesvirus 1 Humans Immediate-Early Proteins - genetics Immediate-Early Proteins - metabolism Immunoblotting Immunoprecipitation Infections Microscopy, Confocal Multiprotein Complexes - metabolism Multiprotein Complexes - physiology Nerve Tissue Proteins - metabolism Nerve Tissue Proteins - physiology Phosphorylation Protein Transport - physiology Proteins Repressor Proteins - metabolism Repressor Proteins - physiology Transcription Factors - metabolism Transcription Factors - physiology Ubiquitin-Protein Ligases Viral proteins Viruses
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