A Mouse Model for Polyomavirus‐Associated Nephropathy of Kidney Transplants
Polyomavirus‐associated nephropathy is an important cause of dysfunction and failure of renal transplants. BK virus is an ubiquitous human polyoma virus that persistently infects the kidney. This otherwise silent infection can reactivate in immunosuppressed individuals, resulting in renal complicati...
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| Veröffentlicht in: | American journal of transplantation 2006-05, Vol.6 (5p1), p.913-922 |
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| container_title | American journal of transplantation |
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| creator | Han Lee, E. D. Kemball, C. C. Wang, J. Dong, Y. Stapler, D. C. Hamby, K. M. Gangappa, S. Newell, K. A. Pearson, T. C. Lukacher, A. E. Larsen, C. P. |
| description | Polyomavirus‐associated nephropathy is an important cause of dysfunction and failure of renal transplants. BK virus is an ubiquitous human polyoma virus that persistently infects the kidney. This otherwise silent infection can reactivate in immunosuppressed individuals, resulting in renal complications. Because polyoma viruses are highly species‐specific, we developed a mouse polyoma virus‐renal transplant model in order to investigate the pathogenesis of polyomavirus‐associated nephropathy. Using this model, we found that polyoma virus preferentially replicates in the allogeneic kidney grafts, accelerating graft failure; thus, this animal model is able to mimic the polyomavirus‐associated nephropathy seen in human renal transplant patients. Acute polyoma virus infection of mouse allograft recipients augmented the alloreactive CD8+ T‐cell response, while maintaining the anti‐viral CD8+ T‐cell response. In addition to the known virus‐induced cytopathology, these findings demonstrate a potential role for an enhanced anti‐donor T‐cell response in the pathogenesis of polyomavirus‐associated nephropathy. |
| doi_str_mv | 10.1111/j.1600-6143.2006.01265.x |
| format | Article |
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D. ; Kemball, C. C. ; Wang, J. ; Dong, Y. ; Stapler, D. C. ; Hamby, K. M. ; Gangappa, S. ; Newell, K. A. ; Pearson, T. C. ; Lukacher, A. E. ; Larsen, C. P.</creator><creatorcontrib>Han Lee, E. D. ; Kemball, C. C. ; Wang, J. ; Dong, Y. ; Stapler, D. C. ; Hamby, K. M. ; Gangappa, S. ; Newell, K. A. ; Pearson, T. C. ; Lukacher, A. E. ; Larsen, C. P.</creatorcontrib><description>Polyomavirus‐associated nephropathy is an important cause of dysfunction and failure of renal transplants. BK virus is an ubiquitous human polyoma virus that persistently infects the kidney. This otherwise silent infection can reactivate in immunosuppressed individuals, resulting in renal complications. Because polyoma viruses are highly species‐specific, we developed a mouse polyoma virus‐renal transplant model in order to investigate the pathogenesis of polyomavirus‐associated nephropathy. Using this model, we found that polyoma virus preferentially replicates in the allogeneic kidney grafts, accelerating graft failure; thus, this animal model is able to mimic the polyomavirus‐associated nephropathy seen in human renal transplant patients. Acute polyoma virus infection of mouse allograft recipients augmented the alloreactive CD8+ T‐cell response, while maintaining the anti‐viral CD8+ T‐cell response. In addition to the known virus‐induced cytopathology, these findings demonstrate a potential role for an enhanced anti‐donor T‐cell response in the pathogenesis of polyomavirus‐associated nephropathy.</description><identifier>ISSN: 1600-6135</identifier><identifier>EISSN: 1600-6143</identifier><identifier>DOI: 10.1111/j.1600-6143.2006.01265.x</identifier><identifier>PMID: 16611327</identifier><language>eng</language><publisher>Oxford UK: Blackwell Publishing Ltd</publisher><subject>Animals ; Base Sequence ; Biological and medical sciences ; BK virus ; CD8-Positive T-Lymphocytes - immunology ; DNA Primers ; kidney ; Kidney Transplantation - pathology ; Medical sciences ; Mice ; Models, Animal ; Nephrectomy ; nephropathy ; Polymerase Chain Reaction ; Polyomavirus ; Polyomavirus - genetics ; Polyomavirus - isolation & purification ; Polyomavirus Infections - pathology ; Postoperative Complications - pathology ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; transplant ; Tumor Virus Infections - pathology ; Viral Load ; Viral Plaque Assay</subject><ispartof>American journal of transplantation, 2006-05, Vol.6 (5p1), p.913-922</ispartof><rights>2006 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4785-bf3fe7ebfee5d34f7af00c2aa72a22b76654098060eb739f341a0952954898793</citedby><cites>FETCH-LOGICAL-c4785-bf3fe7ebfee5d34f7af00c2aa72a22b76654098060eb739f341a0952954898793</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1600-6143.2006.01265.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1600-6143.2006.01265.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17718208$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16611327$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Han Lee, E. D.</creatorcontrib><creatorcontrib>Kemball, C. C.</creatorcontrib><creatorcontrib>Wang, J.</creatorcontrib><creatorcontrib>Dong, Y.</creatorcontrib><creatorcontrib>Stapler, D. C.</creatorcontrib><creatorcontrib>Hamby, K. M.</creatorcontrib><creatorcontrib>Gangappa, S.</creatorcontrib><creatorcontrib>Newell, K. A.</creatorcontrib><creatorcontrib>Pearson, T. C.</creatorcontrib><creatorcontrib>Lukacher, A. E.</creatorcontrib><creatorcontrib>Larsen, C. P.</creatorcontrib><title>A Mouse Model for Polyomavirus‐Associated Nephropathy of Kidney Transplants</title><title>American journal of transplantation</title><addtitle>Am J Transplant</addtitle><description>Polyomavirus‐associated nephropathy is an important cause of dysfunction and failure of renal transplants. BK virus is an ubiquitous human polyoma virus that persistently infects the kidney. This otherwise silent infection can reactivate in immunosuppressed individuals, resulting in renal complications. Because polyoma viruses are highly species‐specific, we developed a mouse polyoma virus‐renal transplant model in order to investigate the pathogenesis of polyomavirus‐associated nephropathy. Using this model, we found that polyoma virus preferentially replicates in the allogeneic kidney grafts, accelerating graft failure; thus, this animal model is able to mimic the polyomavirus‐associated nephropathy seen in human renal transplant patients. Acute polyoma virus infection of mouse allograft recipients augmented the alloreactive CD8+ T‐cell response, while maintaining the anti‐viral CD8+ T‐cell response. In addition to the known virus‐induced cytopathology, these findings demonstrate a potential role for an enhanced anti‐donor T‐cell response in the pathogenesis of polyomavirus‐associated nephropathy.</description><subject>Animals</subject><subject>Base Sequence</subject><subject>Biological and medical sciences</subject><subject>BK virus</subject><subject>CD8-Positive T-Lymphocytes - immunology</subject><subject>DNA Primers</subject><subject>kidney</subject><subject>Kidney Transplantation - pathology</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Models, Animal</subject><subject>Nephrectomy</subject><subject>nephropathy</subject><subject>Polymerase Chain Reaction</subject><subject>Polyomavirus</subject><subject>Polyomavirus - genetics</subject><subject>Polyomavirus - isolation & purification</subject><subject>Polyomavirus Infections - pathology</subject><subject>Postoperative Complications - pathology</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>transplant</subject><subject>Tumor Virus Infections - pathology</subject><subject>Viral Load</subject><subject>Viral Plaque Assay</subject><issn>1600-6135</issn><issn>1600-6143</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkLtOwzAUhi0EgnJ5BZQFtgZfEtsZGKqKe7kMZbac5FikSutgt9BsPALPyJPgtBWM4ME-kr_z-_hDKCI4JmGdTWLCMe5zkrCYYsxjTChP4-UW6v1cbP_ULN1D-95PMCaCSrqL9gjnhDAqeuh-EN3bhYewl1BHxrroydatneq3yi3818fnwHtbVHoOZfQAzYuzjZ6_tJE10V1VzqCNxk7PfFPr2dwfoh2jaw9Hm_MAPV9ejIfX_dHj1c1wMOoXiZBpPzfMgIDcAKQlS4zQBuOCai2opjQXnKcJziTmGHLBMsMSonGW0ixNZCZFxg7Q6Tq3cfZ1AX6uppUvoA5DQPiN4kJywgX_EySZDJGrRLkGC2e9d2BU46qpdq0iWHXO1UR1OlWnVnXO1cq5WobW480bi3wK5W_jRnIATjaA9oWuTfBVVP6XE4JIimXgztfce1VD--8B1OB23FXsG3bvnMU</recordid><startdate>200605</startdate><enddate>200605</enddate><creator>Han Lee, E. D.</creator><creator>Kemball, C. C.</creator><creator>Wang, J.</creator><creator>Dong, Y.</creator><creator>Stapler, D. C.</creator><creator>Hamby, K. M.</creator><creator>Gangappa, S.</creator><creator>Newell, K. A.</creator><creator>Pearson, T. C.</creator><creator>Lukacher, A. E.</creator><creator>Larsen, C. P.</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>200605</creationdate><title>A Mouse Model for Polyomavirus‐Associated Nephropathy of Kidney Transplants</title><author>Han Lee, E. D. ; Kemball, C. C. ; Wang, J. ; Dong, Y. ; Stapler, D. C. ; Hamby, K. M. ; Gangappa, S. ; Newell, K. A. ; Pearson, T. C. ; Lukacher, A. E. ; Larsen, C. P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4785-bf3fe7ebfee5d34f7af00c2aa72a22b76654098060eb739f341a0952954898793</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Animals</topic><topic>Base Sequence</topic><topic>Biological and medical sciences</topic><topic>BK virus</topic><topic>CD8-Positive T-Lymphocytes - immunology</topic><topic>DNA Primers</topic><topic>kidney</topic><topic>Kidney Transplantation - pathology</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Models, Animal</topic><topic>Nephrectomy</topic><topic>nephropathy</topic><topic>Polymerase Chain Reaction</topic><topic>Polyomavirus</topic><topic>Polyomavirus - genetics</topic><topic>Polyomavirus - isolation & purification</topic><topic>Polyomavirus Infections - pathology</topic><topic>Postoperative Complications - pathology</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>transplant</topic><topic>Tumor Virus Infections - pathology</topic><topic>Viral Load</topic><topic>Viral Plaque Assay</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Han Lee, E. D.</creatorcontrib><creatorcontrib>Kemball, C. C.</creatorcontrib><creatorcontrib>Wang, J.</creatorcontrib><creatorcontrib>Dong, Y.</creatorcontrib><creatorcontrib>Stapler, D. C.</creatorcontrib><creatorcontrib>Hamby, K. M.</creatorcontrib><creatorcontrib>Gangappa, S.</creatorcontrib><creatorcontrib>Newell, K. A.</creatorcontrib><creatorcontrib>Pearson, T. C.</creatorcontrib><creatorcontrib>Lukacher, A. E.</creatorcontrib><creatorcontrib>Larsen, C. 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P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A Mouse Model for Polyomavirus‐Associated Nephropathy of Kidney Transplants</atitle><jtitle>American journal of transplantation</jtitle><addtitle>Am J Transplant</addtitle><date>2006-05</date><risdate>2006</risdate><volume>6</volume><issue>5p1</issue><spage>913</spage><epage>922</epage><pages>913-922</pages><issn>1600-6135</issn><eissn>1600-6143</eissn><abstract>Polyomavirus‐associated nephropathy is an important cause of dysfunction and failure of renal transplants. BK virus is an ubiquitous human polyoma virus that persistently infects the kidney. This otherwise silent infection can reactivate in immunosuppressed individuals, resulting in renal complications. Because polyoma viruses are highly species‐specific, we developed a mouse polyoma virus‐renal transplant model in order to investigate the pathogenesis of polyomavirus‐associated nephropathy. Using this model, we found that polyoma virus preferentially replicates in the allogeneic kidney grafts, accelerating graft failure; thus, this animal model is able to mimic the polyomavirus‐associated nephropathy seen in human renal transplant patients. Acute polyoma virus infection of mouse allograft recipients augmented the alloreactive CD8+ T‐cell response, while maintaining the anti‐viral CD8+ T‐cell response. In addition to the known virus‐induced cytopathology, these findings demonstrate a potential role for an enhanced anti‐donor T‐cell response in the pathogenesis of polyomavirus‐associated nephropathy.</abstract><cop>Oxford UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>16611327</pmid><doi>10.1111/j.1600-6143.2006.01265.x</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; Wiley Online Library All Journals; Alma/SFX Local Collection |
| subjects | Animals Base Sequence Biological and medical sciences BK virus CD8-Positive T-Lymphocytes - immunology DNA Primers kidney Kidney Transplantation - pathology Medical sciences Mice Models, Animal Nephrectomy nephropathy Polymerase Chain Reaction Polyomavirus Polyomavirus - genetics Polyomavirus - isolation & purification Polyomavirus Infections - pathology Postoperative Complications - pathology Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases transplant Tumor Virus Infections - pathology Viral Load Viral Plaque Assay |
| title | A Mouse Model for Polyomavirus‐Associated Nephropathy of Kidney Transplants |
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