Impact of sentinel lymph node biopsy in patients with Merkel cell carcinoma: results of a prospective study and review of the literature
Merkel cell carcinoma (MCC) is the most aggressive of the cutaneous malignancies, showing a propensity to spread to regional lymph nodes (LNs). The aim of this prospective study was to examine the feasibility and clinical impact of sentinel lymph node biopsy (SLNB) in this cutaneous malignancy. The...
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| Veröffentlicht in: | European journal of nuclear medicine and molecular imaging 2006-04, Vol.33 (4), p.433-440 |
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| creator | Maza, Sofiane Trefzer, Uwe Hofmann, Maja Schneider, Silke Voit, Christiane Krössin, Thomas Zander, Andreas Audring, Heike Sterry, Wolfram Munz, Dieter L |
| description | Merkel cell carcinoma (MCC) is the most aggressive of the cutaneous malignancies, showing a propensity to spread to regional lymph nodes (LNs). The aim of this prospective study was to examine the feasibility and clinical impact of sentinel lymph node biopsy (SLNB) in this cutaneous malignancy.
The study population comprised 23 patients with stage I MCC (median age 70 years, range 50-85 years). Lymphoscintigraphic mapping with( 99 m)Tc-nanocolloid was performed in all patients. Sentinel lymph nodes (SLNs) were identified, excised and analysed in serial sections by conventional histopathology and cytokeratin-20 immunohistochemistry.
Metastatic disease was determined in the SLNs of 11 patients (47.8%). Elective lymph node dissection (ELND) was performed in eight of these 11 patients, four of whom had additional positive LNs. During follow-up (median 36.1 months, range 3-79 months), seven of the 23 patients (30%) relapsed: four had a local recurrence and three, in-transit metastases. Recurrence developed in two SLN-negative patients with local LN metastases and in one SLN-positive patient with distant metastases. This patient died, representing the only tumour-related death in our sample. Median survival was 49.1 and 35.5 months for SLN-negative and SLN-positive patients, respectively. This difference was not statistically significant (p=0.3452).
SLNB allows for exact nodal staging in patients with MCC. Whether additional ELND is of further benefit remains unclear. |
| doi_str_mv | 10.1007/s00259-005-0014-1 |
| format | Article |
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The study population comprised 23 patients with stage I MCC (median age 70 years, range 50-85 years). Lymphoscintigraphic mapping with( 99 m)Tc-nanocolloid was performed in all patients. Sentinel lymph nodes (SLNs) were identified, excised and analysed in serial sections by conventional histopathology and cytokeratin-20 immunohistochemistry.
Metastatic disease was determined in the SLNs of 11 patients (47.8%). Elective lymph node dissection (ELND) was performed in eight of these 11 patients, four of whom had additional positive LNs. During follow-up (median 36.1 months, range 3-79 months), seven of the 23 patients (30%) relapsed: four had a local recurrence and three, in-transit metastases. Recurrence developed in two SLN-negative patients with local LN metastases and in one SLN-positive patient with distant metastases. This patient died, representing the only tumour-related death in our sample. Median survival was 49.1 and 35.5 months for SLN-negative and SLN-positive patients, respectively. This difference was not statistically significant (p=0.3452).
SLNB allows for exact nodal staging in patients with MCC. Whether additional ELND is of further benefit remains unclear.</description><identifier>ISSN: 1619-7070</identifier><identifier>EISSN: 1619-7089</identifier><identifier>DOI: 10.1007/s00259-005-0014-1</identifier><identifier>PMID: 16432719</identifier><language>eng</language><publisher>Germany: Springer Nature B.V</publisher><subject>Aged ; Carcinoma, Merkel Cell - diagnostic imaging ; Carcinoma, Merkel Cell - mortality ; Carcinoma, Merkel Cell - pathology ; Carcinoma, Merkel Cell - secondary ; Female ; Germany - epidemiology ; Humans ; Lymph Nodes - diagnostic imaging ; Lymph Nodes - pathology ; Lymphatic Metastasis ; Male ; Middle Aged ; Outcome Assessment (Health Care) - methods ; Prognosis ; Prospective Studies ; Radionuclide Imaging ; Reproducibility of Results ; Risk Assessment - methods ; Risk Factors ; Sensitivity and Specificity ; Skin Neoplasms - diagnostic imaging ; Skin Neoplasms - mortality ; Skin Neoplasms - pathology ; Skin Neoplasms - secondary</subject><ispartof>European journal of nuclear medicine and molecular imaging, 2006-04, Vol.33 (4), p.433-440</ispartof><rights>Springer-Verlag 2006</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c326t-dffb86da9a9cb8ebb89fa3826f98d168f652f0cfcf474723a253d18800d3d4e23</citedby><cites>FETCH-LOGICAL-c326t-dffb86da9a9cb8ebb89fa3826f98d168f652f0cfcf474723a253d18800d3d4e23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16432719$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Maza, Sofiane</creatorcontrib><creatorcontrib>Trefzer, Uwe</creatorcontrib><creatorcontrib>Hofmann, Maja</creatorcontrib><creatorcontrib>Schneider, Silke</creatorcontrib><creatorcontrib>Voit, Christiane</creatorcontrib><creatorcontrib>Krössin, Thomas</creatorcontrib><creatorcontrib>Zander, Andreas</creatorcontrib><creatorcontrib>Audring, Heike</creatorcontrib><creatorcontrib>Sterry, Wolfram</creatorcontrib><creatorcontrib>Munz, Dieter L</creatorcontrib><title>Impact of sentinel lymph node biopsy in patients with Merkel cell carcinoma: results of a prospective study and review of the literature</title><title>European journal of nuclear medicine and molecular imaging</title><addtitle>Eur J Nucl Med Mol Imaging</addtitle><description>Merkel cell carcinoma (MCC) is the most aggressive of the cutaneous malignancies, showing a propensity to spread to regional lymph nodes (LNs). The aim of this prospective study was to examine the feasibility and clinical impact of sentinel lymph node biopsy (SLNB) in this cutaneous malignancy.
The study population comprised 23 patients with stage I MCC (median age 70 years, range 50-85 years). Lymphoscintigraphic mapping with( 99 m)Tc-nanocolloid was performed in all patients. Sentinel lymph nodes (SLNs) were identified, excised and analysed in serial sections by conventional histopathology and cytokeratin-20 immunohistochemistry.
Metastatic disease was determined in the SLNs of 11 patients (47.8%). Elective lymph node dissection (ELND) was performed in eight of these 11 patients, four of whom had additional positive LNs. During follow-up (median 36.1 months, range 3-79 months), seven of the 23 patients (30%) relapsed: four had a local recurrence and three, in-transit metastases. Recurrence developed in two SLN-negative patients with local LN metastases and in one SLN-positive patient with distant metastases. This patient died, representing the only tumour-related death in our sample. Median survival was 49.1 and 35.5 months for SLN-negative and SLN-positive patients, respectively. This difference was not statistically significant (p=0.3452).
SLNB allows for exact nodal staging in patients with MCC. Whether additional ELND is of further benefit remains unclear.</description><subject>Aged</subject><subject>Carcinoma, Merkel Cell - diagnostic imaging</subject><subject>Carcinoma, Merkel Cell - mortality</subject><subject>Carcinoma, Merkel Cell - pathology</subject><subject>Carcinoma, Merkel Cell - secondary</subject><subject>Female</subject><subject>Germany - epidemiology</subject><subject>Humans</subject><subject>Lymph Nodes - diagnostic imaging</subject><subject>Lymph Nodes - pathology</subject><subject>Lymphatic Metastasis</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Outcome Assessment (Health Care) - methods</subject><subject>Prognosis</subject><subject>Prospective Studies</subject><subject>Radionuclide Imaging</subject><subject>Reproducibility of Results</subject><subject>Risk Assessment - methods</subject><subject>Risk Factors</subject><subject>Sensitivity and Specificity</subject><subject>Skin Neoplasms - diagnostic imaging</subject><subject>Skin Neoplasms - mortality</subject><subject>Skin Neoplasms - pathology</subject><subject>Skin Neoplasms - secondary</subject><issn>1619-7070</issn><issn>1619-7089</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNpdkctOHDEQRa0oUSAkH8AGWVlk14kf3X6wi1AgSETZwNpy22WNoV_YbtD8AZ-NRzMiUhbl8uLUVZUOQqeUfKeEyB-ZENbphpCuFm0b-g4dU0F1I4nS79_-khyhTznfV0YxpT-iIypaziTVx-jlelysK3gOOMNU4gQDHrbjssHT7AH3cV7yFscJL7bECmT8HMsG_4H0UEkHQ31scnGaR3uOE-R1qExNs3hJc17AlfgEOJfVb7GdfEWeIjzviLIBPMQCyZY1wWf0Idghw5dDP0F3l79uL343N3-vri9-3jSOM1EaH0KvhLfaatcr6Hulg-WKiaCVp0IF0bFAXHChla1k3LKOe6oUIZ77Fhg_Qd_2uXW9xxVyMWPMuzvsBPOajZBKEC15Bb_-B97Pa5rqbobRVnRCc1khuodcPTYnCGZJcbRpaygxO0dm78hUR2bnyNA6c3YIXvsR_L-JgxT-CtBujvg</recordid><startdate>20060401</startdate><enddate>20060401</enddate><creator>Maza, Sofiane</creator><creator>Trefzer, Uwe</creator><creator>Hofmann, Maja</creator><creator>Schneider, Silke</creator><creator>Voit, Christiane</creator><creator>Krössin, Thomas</creator><creator>Zander, Andreas</creator><creator>Audring, Heike</creator><creator>Sterry, Wolfram</creator><creator>Munz, Dieter L</creator><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20060401</creationdate><title>Impact of sentinel lymph node biopsy in patients with Merkel cell carcinoma: results of a prospective study and review of the literature</title><author>Maza, Sofiane ; Trefzer, Uwe ; Hofmann, Maja ; Schneider, Silke ; Voit, Christiane ; Krössin, Thomas ; Zander, Andreas ; Audring, Heike ; Sterry, Wolfram ; Munz, Dieter L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c326t-dffb86da9a9cb8ebb89fa3826f98d168f652f0cfcf474723a253d18800d3d4e23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Aged</topic><topic>Carcinoma, Merkel Cell - 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Academic</collection><jtitle>European journal of nuclear medicine and molecular imaging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Maza, Sofiane</au><au>Trefzer, Uwe</au><au>Hofmann, Maja</au><au>Schneider, Silke</au><au>Voit, Christiane</au><au>Krössin, Thomas</au><au>Zander, Andreas</au><au>Audring, Heike</au><au>Sterry, Wolfram</au><au>Munz, Dieter L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impact of sentinel lymph node biopsy in patients with Merkel cell carcinoma: results of a prospective study and review of the literature</atitle><jtitle>European journal of nuclear medicine and molecular imaging</jtitle><addtitle>Eur J Nucl Med Mol Imaging</addtitle><date>2006-04-01</date><risdate>2006</risdate><volume>33</volume><issue>4</issue><spage>433</spage><epage>440</epage><pages>433-440</pages><issn>1619-7070</issn><eissn>1619-7089</eissn><abstract>Merkel cell carcinoma (MCC) is the most aggressive of the cutaneous malignancies, showing a propensity to spread to regional lymph nodes (LNs). The aim of this prospective study was to examine the feasibility and clinical impact of sentinel lymph node biopsy (SLNB) in this cutaneous malignancy.
The study population comprised 23 patients with stage I MCC (median age 70 years, range 50-85 years). Lymphoscintigraphic mapping with( 99 m)Tc-nanocolloid was performed in all patients. Sentinel lymph nodes (SLNs) were identified, excised and analysed in serial sections by conventional histopathology and cytokeratin-20 immunohistochemistry.
Metastatic disease was determined in the SLNs of 11 patients (47.8%). Elective lymph node dissection (ELND) was performed in eight of these 11 patients, four of whom had additional positive LNs. During follow-up (median 36.1 months, range 3-79 months), seven of the 23 patients (30%) relapsed: four had a local recurrence and three, in-transit metastases. Recurrence developed in two SLN-negative patients with local LN metastases and in one SLN-positive patient with distant metastases. This patient died, representing the only tumour-related death in our sample. Median survival was 49.1 and 35.5 months for SLN-negative and SLN-positive patients, respectively. This difference was not statistically significant (p=0.3452).
SLNB allows for exact nodal staging in patients with MCC. Whether additional ELND is of further benefit remains unclear.</abstract><cop>Germany</cop><pub>Springer Nature B.V</pub><pmid>16432719</pmid><doi>10.1007/s00259-005-0014-1</doi><tpages>8</tpages></addata></record> |
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| subjects | Aged Carcinoma, Merkel Cell - diagnostic imaging Carcinoma, Merkel Cell - mortality Carcinoma, Merkel Cell - pathology Carcinoma, Merkel Cell - secondary Female Germany - epidemiology Humans Lymph Nodes - diagnostic imaging Lymph Nodes - pathology Lymphatic Metastasis Male Middle Aged Outcome Assessment (Health Care) - methods Prognosis Prospective Studies Radionuclide Imaging Reproducibility of Results Risk Assessment - methods Risk Factors Sensitivity and Specificity Skin Neoplasms - diagnostic imaging Skin Neoplasms - mortality Skin Neoplasms - pathology Skin Neoplasms - secondary |
| title | Impact of sentinel lymph node biopsy in patients with Merkel cell carcinoma: results of a prospective study and review of the literature |
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