Obstructive sleep apnea syndrome secondary to pharyngolaryngomalacia in a neonate with Down syndrome
We described a case of obstructive sleep apnea secondary (OSAS) to pharyngomalacia and laryngomalacia in a neonate with Down syndrome. She presented with oxygen requirement and paradoxical breathing without stridor. Sleep polysomnography revealed obstructive apnea (obstructive apneic index of 14 h −...
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| Veröffentlicht in: | International journal of pediatric otorhinolaryngology 2005-07, Vol.69 (7), p.919-921 |
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| container_title | International journal of pediatric otorhinolaryngology |
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| creator | Shing Yan Robert, Lee Daniel Kwok-keung, Ng Pok Yu, Chow Ka Li, Kwok |
| description | We described a case of obstructive sleep apnea secondary (OSAS) to pharyngomalacia and laryngomalacia in a neonate with Down syndrome. She presented with oxygen requirement and paradoxical breathing without stridor. Sleep polysomnography revealed obstructive apnea (obstructive apneic index of 14
h
−1). Flexible bronchoscopy revealed collapsed velopharynx and omega-shaped larynx leading to the diagnosis of pharyngolaryngomalacia. She was treated with nasal prong continuous positive airway pressure. On this treatment, repeat polysomnography revealed abolition of obstructive apnea. Our case leads us to speculate that pharyngomalacia is an under-recognized condition in Down syndrome because this is expected to occur as part of generalized floppiness of airway of Down syndrome. In fact pharyngomalacia is a newly described clinical entity, which if unnoticed is associated with failure of supraglottoplasty in relieving symptoms of airway obstruction of laryngomalacia. |
| doi_str_mv | 10.1016/j.ijporl.2005.02.008 |
| format | Article |
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h
−1). Flexible bronchoscopy revealed collapsed velopharynx and omega-shaped larynx leading to the diagnosis of pharyngolaryngomalacia. She was treated with nasal prong continuous positive airway pressure. On this treatment, repeat polysomnography revealed abolition of obstructive apnea. Our case leads us to speculate that pharyngomalacia is an under-recognized condition in Down syndrome because this is expected to occur as part of generalized floppiness of airway of Down syndrome. In fact pharyngomalacia is a newly described clinical entity, which if unnoticed is associated with failure of supraglottoplasty in relieving symptoms of airway obstruction of laryngomalacia.</description><identifier>ISSN: 0165-5876</identifier><identifier>EISSN: 1872-8464</identifier><identifier>DOI: 10.1016/j.ijporl.2005.02.008</identifier><identifier>PMID: 15911009</identifier><language>eng</language><publisher>Ireland: Elsevier Ireland Ltd</publisher><subject>Apnea ; Down syndrome ; Down Syndrome - complications ; Female ; Humans ; Infant, Newborn ; Laryngomalacia ; Larynx - abnormalities ; Obstructive sleep apnea syndrome ; Pharyngolaryngomalacia ; Pharyngomalacia ; Pharynx - abnormalities ; Polysomnography ; Sleep Apnea, Obstructive - diagnosis ; Sleep Apnea, Obstructive - etiology ; Sleep Apnea, Obstructive - therapy</subject><ispartof>International journal of pediatric otorhinolaryngology, 2005-07, Vol.69 (7), p.919-921</ispartof><rights>2005 Elsevier Ireland Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c275t-bbe03c99f74dd9a9e191f2f82961251d213a27ab7bae19bf785c7953483ee62a3</citedby><cites>FETCH-LOGICAL-c275t-bbe03c99f74dd9a9e191f2f82961251d213a27ab7bae19bf785c7953483ee62a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0165587605000753$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15911009$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shing Yan Robert, Lee</creatorcontrib><creatorcontrib>Daniel Kwok-keung, Ng</creatorcontrib><creatorcontrib>Pok Yu, Chow</creatorcontrib><creatorcontrib>Ka Li, Kwok</creatorcontrib><title>Obstructive sleep apnea syndrome secondary to pharyngolaryngomalacia in a neonate with Down syndrome</title><title>International journal of pediatric otorhinolaryngology</title><addtitle>Int J Pediatr Otorhinolaryngol</addtitle><description>We described a case of obstructive sleep apnea secondary (OSAS) to pharyngomalacia and laryngomalacia in a neonate with Down syndrome. She presented with oxygen requirement and paradoxical breathing without stridor. Sleep polysomnography revealed obstructive apnea (obstructive apneic index of 14
h
−1). Flexible bronchoscopy revealed collapsed velopharynx and omega-shaped larynx leading to the diagnosis of pharyngolaryngomalacia. She was treated with nasal prong continuous positive airway pressure. On this treatment, repeat polysomnography revealed abolition of obstructive apnea. Our case leads us to speculate that pharyngomalacia is an under-recognized condition in Down syndrome because this is expected to occur as part of generalized floppiness of airway of Down syndrome. In fact pharyngomalacia is a newly described clinical entity, which if unnoticed is associated with failure of supraglottoplasty in relieving symptoms of airway obstruction of laryngomalacia.</description><subject>Apnea</subject><subject>Down syndrome</subject><subject>Down Syndrome - complications</subject><subject>Female</subject><subject>Humans</subject><subject>Infant, Newborn</subject><subject>Laryngomalacia</subject><subject>Larynx - abnormalities</subject><subject>Obstructive sleep apnea syndrome</subject><subject>Pharyngolaryngomalacia</subject><subject>Pharyngomalacia</subject><subject>Pharynx - abnormalities</subject><subject>Polysomnography</subject><subject>Sleep Apnea, Obstructive - diagnosis</subject><subject>Sleep Apnea, Obstructive - etiology</subject><subject>Sleep Apnea, Obstructive - therapy</subject><issn>0165-5876</issn><issn>1872-8464</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE2P1SAUhonRONfRf2AMK3etB1oKbEzMjF_JJLPRNaFw6nDTQoXemcy_l0lvdOfqEHjOezgPIW8ZtAzY8OHYhuOa8txyANECbwHUM3JgSvJG9UP_nBwqJhqh5HBBXpVyBGAShHhJLpjQjAHoA_G3Y9nyyW3hHmmZEVdq14iWlsfoc1rqJboUvc2PdEt0vauH-CvNe1nsbF2wNERqacQU7Yb0IWx39Do9xL8Zr8mLyc4F35zrJfn55fOPq2_Nze3X71efbhrHpdiacUTonNaT7L3XViPTbOKT4npgXDDPWWe5tKMcbX0aJ6mEk1p0veoQB267S_J-z11z-n3CspklFIfzbOvfTsUMUg2gQFaw30GXUykZJ7PmsNSdDAPzZNcczW7XPNk1wE21W9venfNP44L-X9NZZwU-7gDWLe8DZlNcwOjQh4xuMz6F_0_4A6A7j44</recordid><startdate>200507</startdate><enddate>200507</enddate><creator>Shing Yan Robert, Lee</creator><creator>Daniel Kwok-keung, Ng</creator><creator>Pok Yu, Chow</creator><creator>Ka Li, Kwok</creator><general>Elsevier Ireland Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>8BM</scope></search><sort><creationdate>200507</creationdate><title>Obstructive sleep apnea syndrome secondary to pharyngolaryngomalacia in a neonate with Down syndrome</title><author>Shing Yan Robert, Lee ; Daniel Kwok-keung, Ng ; Pok Yu, Chow ; Ka Li, Kwok</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c275t-bbe03c99f74dd9a9e191f2f82961251d213a27ab7bae19bf785c7953483ee62a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Apnea</topic><topic>Down syndrome</topic><topic>Down Syndrome - complications</topic><topic>Female</topic><topic>Humans</topic><topic>Infant, Newborn</topic><topic>Laryngomalacia</topic><topic>Larynx - abnormalities</topic><topic>Obstructive sleep apnea syndrome</topic><topic>Pharyngolaryngomalacia</topic><topic>Pharyngomalacia</topic><topic>Pharynx - abnormalities</topic><topic>Polysomnography</topic><topic>Sleep Apnea, Obstructive - diagnosis</topic><topic>Sleep Apnea, Obstructive - etiology</topic><topic>Sleep Apnea, Obstructive - therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shing Yan Robert, Lee</creatorcontrib><creatorcontrib>Daniel Kwok-keung, Ng</creatorcontrib><creatorcontrib>Pok Yu, Chow</creatorcontrib><creatorcontrib>Ka Li, Kwok</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>ComDisDome</collection><jtitle>International journal of pediatric otorhinolaryngology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shing Yan Robert, Lee</au><au>Daniel Kwok-keung, Ng</au><au>Pok Yu, Chow</au><au>Ka Li, Kwok</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Obstructive sleep apnea syndrome secondary to pharyngolaryngomalacia in a neonate with Down syndrome</atitle><jtitle>International journal of pediatric otorhinolaryngology</jtitle><addtitle>Int J Pediatr Otorhinolaryngol</addtitle><date>2005-07</date><risdate>2005</risdate><volume>69</volume><issue>7</issue><spage>919</spage><epage>921</epage><pages>919-921</pages><issn>0165-5876</issn><eissn>1872-8464</eissn><abstract>We described a case of obstructive sleep apnea secondary (OSAS) to pharyngomalacia and laryngomalacia in a neonate with Down syndrome. She presented with oxygen requirement and paradoxical breathing without stridor. Sleep polysomnography revealed obstructive apnea (obstructive apneic index of 14
h
−1). Flexible bronchoscopy revealed collapsed velopharynx and omega-shaped larynx leading to the diagnosis of pharyngolaryngomalacia. She was treated with nasal prong continuous positive airway pressure. On this treatment, repeat polysomnography revealed abolition of obstructive apnea. Our case leads us to speculate that pharyngomalacia is an under-recognized condition in Down syndrome because this is expected to occur as part of generalized floppiness of airway of Down syndrome. In fact pharyngomalacia is a newly described clinical entity, which if unnoticed is associated with failure of supraglottoplasty in relieving symptoms of airway obstruction of laryngomalacia.</abstract><cop>Ireland</cop><pub>Elsevier Ireland Ltd</pub><pmid>15911009</pmid><doi>10.1016/j.ijporl.2005.02.008</doi><tpages>3</tpages></addata></record> |
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| identifier | ISSN: 0165-5876 |
| ispartof | International journal of pediatric otorhinolaryngology, 2005-07, Vol.69 (7), p.919-921 |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Apnea Down syndrome Down Syndrome - complications Female Humans Infant, Newborn Laryngomalacia Larynx - abnormalities Obstructive sleep apnea syndrome Pharyngolaryngomalacia Pharyngomalacia Pharynx - abnormalities Polysomnography Sleep Apnea, Obstructive - diagnosis Sleep Apnea, Obstructive - etiology Sleep Apnea, Obstructive - therapy |
| title | Obstructive sleep apnea syndrome secondary to pharyngolaryngomalacia in a neonate with Down syndrome |
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