Complete regression of experimental prostate cancer in nude mice by repeated hyperthermia using magnetite cationic liposomes and a newly developed solenoid containing a ferrite core
BACKGROUND Magnetite cationic liposomes (MCLs) can be used to induce hyperthermia because they generate heat in an alternating magnetic field (AMF). This study aimed at developing more practical method for MCL hyperthermia examining the effect of MCL‐induced hyperthermia on human prostate cancer in...
Gespeichert in:
| Veröffentlicht in: | The Prostate 2006-05, Vol.66 (7), p.718-727 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 727 |
|---|---|
| container_issue | 7 |
| container_start_page | 718 |
| container_title | The Prostate |
| container_volume | 66 |
| creator | Kawai, Noriyasu Ito, Akira Nakahara, Yoko Honda, Hiroyuki Kobayashi, Takeshi Futakuchi, Mitsuru Shirai, Tomoyuki Tozawa, Keiichi Kohri, Kenjiro |
| description | BACKGROUND
Magnetite cationic liposomes (MCLs) can be used to induce hyperthermia because they generate heat in an alternating magnetic field (AMF). This study aimed at developing more practical method for MCL hyperthermia examining the effect of MCL‐induced hyperthermia on human prostate cancer in vivo.
MATERIALS AND METHODS
A newly developed AMF generator incorporating a solenoid with a ferrite core (FC) was used. Human prostate cancer cells (PC‐3 and LNCap) were injected subcutaneously into nude mice. MCLs were injected into tumor nodule and the mice were exposed into AMF three times at 24‐hr intervals (repeated hyperthermia; RH) until complete tumor regression was observed.
RESULTS
Irradiation with an AMF generated by newly developed device can adequately increase the temperature of tumor tissue. Frequent RH resulted in complete tumor regression in all nude mice.
CONCLUSION
RH using MCLs may be a promising new therapy for hormone‐refractory human prostate cancer in the future. Prostate © 2006 Wiley‐Liss, Inc. |
| doi_str_mv | 10.1002/pros.20394 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_67860059</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>67860059</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4614-930e8070d88f7a9a794f6233c3245c5f0d084f2d381aaaa7467200699e8529c13</originalsourceid><addsrcrecordid>eNp9kctu1TAYhCMEoofChgdA3sACKeX3JXGypAdokSqKuIil5Tp_Tg2OHeyENg_G--Fzge7wxgt_MyPPFMVTCicUgL0aY0gnDHgr7hUrCq0sAUR1v1gBk1AKyuVR8Sil7wAZB_awOKK1YBVtqlXxex2G0eGEJOImYko2eBJ6grcjRjugn7Qj24BJZ8ZobzAS64mfOySDNUiuliwdMT935HrJquka42A1mZP1GzLojcfJ7sRTNreGODuGFAZMRPuOaOLxxi2kw1_owphdUnDog-2ICTne-q2NJj3GuLMJER8XD3rtEj453MfF13dvv6zPy4vLs_fr1xelETUVZcsBG5DQNU0vdatlK_qacW44E5WpeuigET3reEN1PlLUkgHUbYtNxVpD-XHxYu-bG_g5Y5rUYJNB57THMCdVy6YGqNoMvtyDJleVIvZqzO3puCgKajuS2naodiNl-NnBdb4asLtDD6tk4PkB0Mlo18dcu013nJSUyUZmju65G-tw-U-k-vjp8vPf8HKvsWnC238aHX_k33BZqW8fzpQ8Fc2b83atav4HUOe8vw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>67860059</pqid></control><display><type>article</type><title>Complete regression of experimental prostate cancer in nude mice by repeated hyperthermia using magnetite cationic liposomes and a newly developed solenoid containing a ferrite core</title><source>MEDLINE</source><source>Access via Wiley Online Library</source><creator>Kawai, Noriyasu ; Ito, Akira ; Nakahara, Yoko ; Honda, Hiroyuki ; Kobayashi, Takeshi ; Futakuchi, Mitsuru ; Shirai, Tomoyuki ; Tozawa, Keiichi ; Kohri, Kenjiro</creator><creatorcontrib>Kawai, Noriyasu ; Ito, Akira ; Nakahara, Yoko ; Honda, Hiroyuki ; Kobayashi, Takeshi ; Futakuchi, Mitsuru ; Shirai, Tomoyuki ; Tozawa, Keiichi ; Kohri, Kenjiro</creatorcontrib><description>BACKGROUND
Magnetite cationic liposomes (MCLs) can be used to induce hyperthermia because they generate heat in an alternating magnetic field (AMF). This study aimed at developing more practical method for MCL hyperthermia examining the effect of MCL‐induced hyperthermia on human prostate cancer in vivo.
MATERIALS AND METHODS
A newly developed AMF generator incorporating a solenoid with a ferrite core (FC) was used. Human prostate cancer cells (PC‐3 and LNCap) were injected subcutaneously into nude mice. MCLs were injected into tumor nodule and the mice were exposed into AMF three times at 24‐hr intervals (repeated hyperthermia; RH) until complete tumor regression was observed.
RESULTS
Irradiation with an AMF generated by newly developed device can adequately increase the temperature of tumor tissue. Frequent RH resulted in complete tumor regression in all nude mice.
CONCLUSION
RH using MCLs may be a promising new therapy for hormone‐refractory human prostate cancer in the future. Prostate © 2006 Wiley‐Liss, Inc.</description><identifier>ISSN: 0270-4137</identifier><identifier>EISSN: 1097-0045</identifier><identifier>DOI: 10.1002/pros.20394</identifier><identifier>PMID: 16425185</identifier><identifier>CODEN: PRSTDS</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Animals ; Biological and medical sciences ; Combined Modality Therapy ; complete regression ; ferrite core ; Ferrosoferric Oxide - administration & dosage ; Ferrosoferric Oxide - therapeutic use ; Gynecology. Andrology. Obstetrics ; human prostate cancer ; hyperthermia ; Hyperthermia, Induced ; Indicators and Reagents - administration & dosage ; Indicators and Reagents - therapeutic use ; Iron - administration & dosage ; Iron - therapeutic use ; Liposomes ; magnetite cationic liposome ; Male ; Male genital diseases ; Medical sciences ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Nephrology. Urinary tract diseases ; Prostatic Neoplasms - therapy ; Prostatic Neoplasms - veterinary ; Temperature ; Treatment Outcome ; Tumors ; Tumors of the urinary system ; Urinary tract. Prostate gland</subject><ispartof>The Prostate, 2006-05, Vol.66 (7), p.718-727</ispartof><rights>Copyright © 2006 Wiley‐Liss, Inc.</rights><rights>2006 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4614-930e8070d88f7a9a794f6233c3245c5f0d084f2d381aaaa7467200699e8529c13</citedby><cites>FETCH-LOGICAL-c4614-930e8070d88f7a9a794f6233c3245c5f0d084f2d381aaaa7467200699e8529c13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fpros.20394$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fpros.20394$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17712787$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16425185$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kawai, Noriyasu</creatorcontrib><creatorcontrib>Ito, Akira</creatorcontrib><creatorcontrib>Nakahara, Yoko</creatorcontrib><creatorcontrib>Honda, Hiroyuki</creatorcontrib><creatorcontrib>Kobayashi, Takeshi</creatorcontrib><creatorcontrib>Futakuchi, Mitsuru</creatorcontrib><creatorcontrib>Shirai, Tomoyuki</creatorcontrib><creatorcontrib>Tozawa, Keiichi</creatorcontrib><creatorcontrib>Kohri, Kenjiro</creatorcontrib><title>Complete regression of experimental prostate cancer in nude mice by repeated hyperthermia using magnetite cationic liposomes and a newly developed solenoid containing a ferrite core</title><title>The Prostate</title><addtitle>Prostate</addtitle><description>BACKGROUND
Magnetite cationic liposomes (MCLs) can be used to induce hyperthermia because they generate heat in an alternating magnetic field (AMF). This study aimed at developing more practical method for MCL hyperthermia examining the effect of MCL‐induced hyperthermia on human prostate cancer in vivo.
MATERIALS AND METHODS
A newly developed AMF generator incorporating a solenoid with a ferrite core (FC) was used. Human prostate cancer cells (PC‐3 and LNCap) were injected subcutaneously into nude mice. MCLs were injected into tumor nodule and the mice were exposed into AMF three times at 24‐hr intervals (repeated hyperthermia; RH) until complete tumor regression was observed.
RESULTS
Irradiation with an AMF generated by newly developed device can adequately increase the temperature of tumor tissue. Frequent RH resulted in complete tumor regression in all nude mice.
CONCLUSION
RH using MCLs may be a promising new therapy for hormone‐refractory human prostate cancer in the future. Prostate © 2006 Wiley‐Liss, Inc.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Combined Modality Therapy</subject><subject>complete regression</subject><subject>ferrite core</subject><subject>Ferrosoferric Oxide - administration & dosage</subject><subject>Ferrosoferric Oxide - therapeutic use</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>human prostate cancer</subject><subject>hyperthermia</subject><subject>Hyperthermia, Induced</subject><subject>Indicators and Reagents - administration & dosage</subject><subject>Indicators and Reagents - therapeutic use</subject><subject>Iron - administration & dosage</subject><subject>Iron - therapeutic use</subject><subject>Liposomes</subject><subject>magnetite cationic liposome</subject><subject>Male</subject><subject>Male genital diseases</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Mice, Nude</subject><subject>Nephrology. Urinary tract diseases</subject><subject>Prostatic Neoplasms - therapy</subject><subject>Prostatic Neoplasms - veterinary</subject><subject>Temperature</subject><subject>Treatment Outcome</subject><subject>Tumors</subject><subject>Tumors of the urinary system</subject><subject>Urinary tract. Prostate gland</subject><issn>0270-4137</issn><issn>1097-0045</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kctu1TAYhCMEoofChgdA3sACKeX3JXGypAdokSqKuIil5Tp_Tg2OHeyENg_G--Fzge7wxgt_MyPPFMVTCicUgL0aY0gnDHgr7hUrCq0sAUR1v1gBk1AKyuVR8Sil7wAZB_awOKK1YBVtqlXxex2G0eGEJOImYko2eBJ6grcjRjugn7Qj24BJZ8ZobzAS64mfOySDNUiuliwdMT935HrJquka42A1mZP1GzLojcfJ7sRTNreGODuGFAZMRPuOaOLxxi2kw1_owphdUnDog-2ICTne-q2NJj3GuLMJER8XD3rtEj453MfF13dvv6zPy4vLs_fr1xelETUVZcsBG5DQNU0vdatlK_qacW44E5WpeuigET3reEN1PlLUkgHUbYtNxVpD-XHxYu-bG_g5Y5rUYJNB57THMCdVy6YGqNoMvtyDJleVIvZqzO3puCgKajuS2naodiNl-NnBdb4asLtDD6tk4PkB0Mlo18dcu013nJSUyUZmju65G-tw-U-k-vjp8vPf8HKvsWnC238aHX_k33BZqW8fzpQ8Fc2b83atav4HUOe8vw</recordid><startdate>20060515</startdate><enddate>20060515</enddate><creator>Kawai, Noriyasu</creator><creator>Ito, Akira</creator><creator>Nakahara, Yoko</creator><creator>Honda, Hiroyuki</creator><creator>Kobayashi, Takeshi</creator><creator>Futakuchi, Mitsuru</creator><creator>Shirai, Tomoyuki</creator><creator>Tozawa, Keiichi</creator><creator>Kohri, Kenjiro</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley-Liss</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20060515</creationdate><title>Complete regression of experimental prostate cancer in nude mice by repeated hyperthermia using magnetite cationic liposomes and a newly developed solenoid containing a ferrite core</title><author>Kawai, Noriyasu ; Ito, Akira ; Nakahara, Yoko ; Honda, Hiroyuki ; Kobayashi, Takeshi ; Futakuchi, Mitsuru ; Shirai, Tomoyuki ; Tozawa, Keiichi ; Kohri, Kenjiro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4614-930e8070d88f7a9a794f6233c3245c5f0d084f2d381aaaa7467200699e8529c13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Combined Modality Therapy</topic><topic>complete regression</topic><topic>ferrite core</topic><topic>Ferrosoferric Oxide - administration & dosage</topic><topic>Ferrosoferric Oxide - therapeutic use</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>human prostate cancer</topic><topic>hyperthermia</topic><topic>Hyperthermia, Induced</topic><topic>Indicators and Reagents - administration & dosage</topic><topic>Indicators and Reagents - therapeutic use</topic><topic>Iron - administration & dosage</topic><topic>Iron - therapeutic use</topic><topic>Liposomes</topic><topic>magnetite cationic liposome</topic><topic>Male</topic><topic>Male genital diseases</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Mice, Nude</topic><topic>Nephrology. Urinary tract diseases</topic><topic>Prostatic Neoplasms - therapy</topic><topic>Prostatic Neoplasms - veterinary</topic><topic>Temperature</topic><topic>Treatment Outcome</topic><topic>Tumors</topic><topic>Tumors of the urinary system</topic><topic>Urinary tract. Prostate gland</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kawai, Noriyasu</creatorcontrib><creatorcontrib>Ito, Akira</creatorcontrib><creatorcontrib>Nakahara, Yoko</creatorcontrib><creatorcontrib>Honda, Hiroyuki</creatorcontrib><creatorcontrib>Kobayashi, Takeshi</creatorcontrib><creatorcontrib>Futakuchi, Mitsuru</creatorcontrib><creatorcontrib>Shirai, Tomoyuki</creatorcontrib><creatorcontrib>Tozawa, Keiichi</creatorcontrib><creatorcontrib>Kohri, Kenjiro</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Prostate</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kawai, Noriyasu</au><au>Ito, Akira</au><au>Nakahara, Yoko</au><au>Honda, Hiroyuki</au><au>Kobayashi, Takeshi</au><au>Futakuchi, Mitsuru</au><au>Shirai, Tomoyuki</au><au>Tozawa, Keiichi</au><au>Kohri, Kenjiro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Complete regression of experimental prostate cancer in nude mice by repeated hyperthermia using magnetite cationic liposomes and a newly developed solenoid containing a ferrite core</atitle><jtitle>The Prostate</jtitle><addtitle>Prostate</addtitle><date>2006-05-15</date><risdate>2006</risdate><volume>66</volume><issue>7</issue><spage>718</spage><epage>727</epage><pages>718-727</pages><issn>0270-4137</issn><eissn>1097-0045</eissn><coden>PRSTDS</coden><abstract>BACKGROUND
Magnetite cationic liposomes (MCLs) can be used to induce hyperthermia because they generate heat in an alternating magnetic field (AMF). This study aimed at developing more practical method for MCL hyperthermia examining the effect of MCL‐induced hyperthermia on human prostate cancer in vivo.
MATERIALS AND METHODS
A newly developed AMF generator incorporating a solenoid with a ferrite core (FC) was used. Human prostate cancer cells (PC‐3 and LNCap) were injected subcutaneously into nude mice. MCLs were injected into tumor nodule and the mice were exposed into AMF three times at 24‐hr intervals (repeated hyperthermia; RH) until complete tumor regression was observed.
RESULTS
Irradiation with an AMF generated by newly developed device can adequately increase the temperature of tumor tissue. Frequent RH resulted in complete tumor regression in all nude mice.
CONCLUSION
RH using MCLs may be a promising new therapy for hormone‐refractory human prostate cancer in the future. Prostate © 2006 Wiley‐Liss, Inc.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>16425185</pmid><doi>10.1002/pros.20394</doi><tpages>10</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0270-4137 |
| ispartof | The Prostate, 2006-05, Vol.66 (7), p.718-727 |
| issn | 0270-4137 1097-0045 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_67860059 |
| source | MEDLINE; Access via Wiley Online Library |
| subjects | Animals Biological and medical sciences Combined Modality Therapy complete regression ferrite core Ferrosoferric Oxide - administration & dosage Ferrosoferric Oxide - therapeutic use Gynecology. Andrology. Obstetrics human prostate cancer hyperthermia Hyperthermia, Induced Indicators and Reagents - administration & dosage Indicators and Reagents - therapeutic use Iron - administration & dosage Iron - therapeutic use Liposomes magnetite cationic liposome Male Male genital diseases Medical sciences Mice Mice, Inbred BALB C Mice, Nude Nephrology. Urinary tract diseases Prostatic Neoplasms - therapy Prostatic Neoplasms - veterinary Temperature Treatment Outcome Tumors Tumors of the urinary system Urinary tract. Prostate gland |
| title | Complete regression of experimental prostate cancer in nude mice by repeated hyperthermia using magnetite cationic liposomes and a newly developed solenoid containing a ferrite core |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-22T08%3A34%3A39IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Complete%20regression%20of%20experimental%20prostate%20cancer%20in%20nude%20mice%20by%20repeated%20hyperthermia%20using%20magnetite%20cationic%20liposomes%20and%20a%20newly%20developed%20solenoid%20containing%20a%20ferrite%20core&rft.jtitle=The%20Prostate&rft.au=Kawai,%20Noriyasu&rft.date=2006-05-15&rft.volume=66&rft.issue=7&rft.spage=718&rft.epage=727&rft.pages=718-727&rft.issn=0270-4137&rft.eissn=1097-0045&rft.coden=PRSTDS&rft_id=info:doi/10.1002/pros.20394&rft_dat=%3Cproquest_cross%3E67860059%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=67860059&rft_id=info:pmid/16425185&rfr_iscdi=true |