DBC1 re-expression alters the expression of multiple components of the plasminogen pathway
Deleted in bladder cancer 1 (DBC1) is a candidate gene for the bladder tumour suppressor locus at 9q33.1. The function of the gene is currently unknown but a cross-species sequence comparison suggests an important role, as it is highly evolutionarily conserved. Here, we transfected a nonexpressing h...
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| Veröffentlicht in: | Oncogene 2006-04, Vol.25 (16), p.2409-2419 |
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| creator | LOUHELAINEN, J. P HURST, C. D PITT, E NISHIYAMA, H PICKETT, H. A KNOWLES, M. A |
| description | Deleted in bladder cancer 1 (DBC1) is a candidate gene for the bladder tumour suppressor locus at 9q33.1. The function of the gene is currently unknown but a cross-species sequence comparison suggests an important role, as it is highly evolutionarily conserved. Here, we transfected a nonexpressing human bladder cancer cell line with a set of human DBC1 cDNA constructs. The effect on global expression patterns was assessed using cDNA microarrays. The cell clone with the lowest level of DBC1 expression showed induced expression of 26 genes including plasminogen activator inhibitor 2 (SERPINB5; 4.6-fold), heparin-binding EGF-like growth factor precursor (DTR; 4.2-fold), small proline-rich protein 2B (SPRR2B; 3.6-fold), metallothionein 1 isoforms (MT1B/MT1A/MT-1F; from 2.9- to 3.2-fold), tissue-type plasminogen activator precursor (PLAT; 2.8-fold) and urokinase-type plasminogen activator precursor (PLAU; 2.7-fold). In clustering analysis, both PLAT and PLAU clustered with the functionally related urokinase plasminogen activator surface receptor (PLAUR; 1.9-fold). Furthermore, 14 human bladder tumours were analysed by real-time quantitative PCR using gene-specific primers for selected (n=20) genes. The expression levels of SERPINB5, PLAU, PLAUR and MT1 correlated with the DBC1 levels, suggesting previously unknown involvement of DBC1 in the urokinase-plasminogen pathway. |
| doi_str_mv | 10.1038/sj.onc.1209228 |
| format | Article |
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P ; HURST, C. D ; PITT, E ; NISHIYAMA, H ; PICKETT, H. A ; KNOWLES, M. A</creator><creatorcontrib>LOUHELAINEN, J. P ; HURST, C. D ; PITT, E ; NISHIYAMA, H ; PICKETT, H. A ; KNOWLES, M. A</creatorcontrib><description>Deleted in bladder cancer 1 (DBC1) is a candidate gene for the bladder tumour suppressor locus at 9q33.1. The function of the gene is currently unknown but a cross-species sequence comparison suggests an important role, as it is highly evolutionarily conserved. Here, we transfected a nonexpressing human bladder cancer cell line with a set of human DBC1 cDNA constructs. The effect on global expression patterns was assessed using cDNA microarrays. The cell clone with the lowest level of DBC1 expression showed induced expression of 26 genes including plasminogen activator inhibitor 2 (SERPINB5; 4.6-fold), heparin-binding EGF-like growth factor precursor (DTR; 4.2-fold), small proline-rich protein 2B (SPRR2B; 3.6-fold), metallothionein 1 isoforms (MT1B/MT1A/MT-1F; from 2.9- to 3.2-fold), tissue-type plasminogen activator precursor (PLAT; 2.8-fold) and urokinase-type plasminogen activator precursor (PLAU; 2.7-fold). In clustering analysis, both PLAT and PLAU clustered with the functionally related urokinase plasminogen activator surface receptor (PLAUR; 1.9-fold). Furthermore, 14 human bladder tumours were analysed by real-time quantitative PCR using gene-specific primers for selected (n=20) genes. The expression levels of SERPINB5, PLAU, PLAUR and MT1 correlated with the DBC1 levels, suggesting previously unknown involvement of DBC1 in the urokinase-plasminogen pathway.</description><identifier>ISSN: 0950-9232</identifier><identifier>EISSN: 1476-5594</identifier><identifier>DOI: 10.1038/sj.onc.1209228</identifier><identifier>PMID: 16369496</identifier><identifier>CODEN: ONCNES</identifier><language>eng</language><publisher>Basingstoke: Nature Publishing</publisher><subject>Biological and medical sciences ; Bladder cancer ; Cancer ; Cell Line, Tumor ; Cell physiology ; Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes ; Chromosome 9 ; Conserved sequence ; DNA microarrays ; Fundamental and applied biological sciences. Psychology ; Gene expression ; Gene Expression Profiling ; Gene Expression Regulation, Neoplastic ; Genes ; Genes, Tumor Suppressor ; Heparin ; Humans ; Isoforms ; Matrix Metalloproteinases - genetics ; Matrix Metalloproteinases, Membrane-Associated ; Medical sciences ; Metallothionein ; Molecular and cellular biology ; Multigene Family ; Nephrology. Urinary tract diseases ; Oligonucleotide Array Sequence Analysis ; Oncology ; Plasminogen activator inhibitors ; Polymerase Chain Reaction ; Proline ; Protein folding ; Proteins ; Receptors, Cell Surface - genetics ; Receptors, Retinoic Acid - genetics ; Receptors, Urokinase Plasminogen Activator ; Serpins - genetics ; Signal transduction ; Tissue Plasminogen Activator - genetics ; Tumor suppressor genes ; Tumor Suppressor Proteins - genetics ; Tumor Suppressor Proteins - physiology ; Tumors ; Tumors of the urinary system ; U-Plasminogen activator ; Urinary Bladder Neoplasms - genetics ; Urinary system involvement in other diseases. Miscellaneous ; Urinary tract. Prostate gland ; Urokinase-Type Plasminogen Activator - genetics</subject><ispartof>Oncogene, 2006-04, Vol.25 (16), p.2409-2419</ispartof><rights>2006 INIST-CNRS</rights><rights>COPYRIGHT 2006 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Apr 13, 2006</rights><rights>Nature Publishing Group 2006.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c498t-f1c92062a0d54c430b9e0a45b700943dcea4273631d4cdac3d43cfd5834923563</citedby><cites>FETCH-LOGICAL-c498t-f1c92062a0d54c430b9e0a45b700943dcea4273631d4cdac3d43cfd5834923563</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,2728,27929,27930</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17701576$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16369496$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>LOUHELAINEN, J. P</creatorcontrib><creatorcontrib>HURST, C. D</creatorcontrib><creatorcontrib>PITT, E</creatorcontrib><creatorcontrib>NISHIYAMA, H</creatorcontrib><creatorcontrib>PICKETT, H. A</creatorcontrib><creatorcontrib>KNOWLES, M. A</creatorcontrib><title>DBC1 re-expression alters the expression of multiple components of the plasminogen pathway</title><title>Oncogene</title><addtitle>Oncogene</addtitle><description>Deleted in bladder cancer 1 (DBC1) is a candidate gene for the bladder tumour suppressor locus at 9q33.1. The function of the gene is currently unknown but a cross-species sequence comparison suggests an important role, as it is highly evolutionarily conserved. Here, we transfected a nonexpressing human bladder cancer cell line with a set of human DBC1 cDNA constructs. The effect on global expression patterns was assessed using cDNA microarrays. The cell clone with the lowest level of DBC1 expression showed induced expression of 26 genes including plasminogen activator inhibitor 2 (SERPINB5; 4.6-fold), heparin-binding EGF-like growth factor precursor (DTR; 4.2-fold), small proline-rich protein 2B (SPRR2B; 3.6-fold), metallothionein 1 isoforms (MT1B/MT1A/MT-1F; from 2.9- to 3.2-fold), tissue-type plasminogen activator precursor (PLAT; 2.8-fold) and urokinase-type plasminogen activator precursor (PLAU; 2.7-fold). In clustering analysis, both PLAT and PLAU clustered with the functionally related urokinase plasminogen activator surface receptor (PLAUR; 1.9-fold). Furthermore, 14 human bladder tumours were analysed by real-time quantitative PCR using gene-specific primers for selected (n=20) genes. The expression levels of SERPINB5, PLAU, PLAUR and MT1 correlated with the DBC1 levels, suggesting previously unknown involvement of DBC1 in the urokinase-plasminogen pathway.</description><subject>Biological and medical sciences</subject><subject>Bladder cancer</subject><subject>Cancer</subject><subject>Cell Line, Tumor</subject><subject>Cell physiology</subject><subject>Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes</subject><subject>Chromosome 9</subject><subject>Conserved sequence</subject><subject>DNA microarrays</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene expression</subject><subject>Gene Expression Profiling</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Genes</subject><subject>Genes, Tumor Suppressor</subject><subject>Heparin</subject><subject>Humans</subject><subject>Isoforms</subject><subject>Matrix Metalloproteinases - genetics</subject><subject>Matrix Metalloproteinases, Membrane-Associated</subject><subject>Medical sciences</subject><subject>Metallothionein</subject><subject>Molecular and cellular biology</subject><subject>Multigene Family</subject><subject>Nephrology. Urinary tract diseases</subject><subject>Oligonucleotide Array Sequence Analysis</subject><subject>Oncology</subject><subject>Plasminogen activator inhibitors</subject><subject>Polymerase Chain Reaction</subject><subject>Proline</subject><subject>Protein folding</subject><subject>Proteins</subject><subject>Receptors, Cell Surface - genetics</subject><subject>Receptors, Retinoic Acid - genetics</subject><subject>Receptors, Urokinase Plasminogen Activator</subject><subject>Serpins - genetics</subject><subject>Signal transduction</subject><subject>Tissue Plasminogen Activator - genetics</subject><subject>Tumor suppressor genes</subject><subject>Tumor Suppressor Proteins - genetics</subject><subject>Tumor Suppressor Proteins - physiology</subject><subject>Tumors</subject><subject>Tumors of the urinary system</subject><subject>U-Plasminogen activator</subject><subject>Urinary Bladder Neoplasms - genetics</subject><subject>Urinary system involvement in other diseases. Miscellaneous</subject><subject>Urinary tract. 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P ; HURST, C. D ; PITT, E ; NISHIYAMA, H ; PICKETT, H. A ; KNOWLES, M. A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c498t-f1c92062a0d54c430b9e0a45b700943dcea4273631d4cdac3d43cfd5834923563</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Biological and medical sciences</topic><topic>Bladder cancer</topic><topic>Cancer</topic><topic>Cell Line, Tumor</topic><topic>Cell physiology</topic><topic>Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes</topic><topic>Chromosome 9</topic><topic>Conserved sequence</topic><topic>DNA microarrays</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gene expression</topic><topic>Gene Expression Profiling</topic><topic>Gene Expression Regulation, Neoplastic</topic><topic>Genes</topic><topic>Genes, Tumor Suppressor</topic><topic>Heparin</topic><topic>Humans</topic><topic>Isoforms</topic><topic>Matrix Metalloproteinases - genetics</topic><topic>Matrix Metalloproteinases, Membrane-Associated</topic><topic>Medical sciences</topic><topic>Metallothionein</topic><topic>Molecular and cellular biology</topic><topic>Multigene Family</topic><topic>Nephrology. Urinary tract diseases</topic><topic>Oligonucleotide Array Sequence Analysis</topic><topic>Oncology</topic><topic>Plasminogen activator inhibitors</topic><topic>Polymerase Chain Reaction</topic><topic>Proline</topic><topic>Protein folding</topic><topic>Proteins</topic><topic>Receptors, Cell Surface - genetics</topic><topic>Receptors, Retinoic Acid - genetics</topic><topic>Receptors, Urokinase Plasminogen Activator</topic><topic>Serpins - genetics</topic><topic>Signal transduction</topic><topic>Tissue Plasminogen Activator - genetics</topic><topic>Tumor suppressor genes</topic><topic>Tumor Suppressor Proteins - genetics</topic><topic>Tumor Suppressor Proteins - physiology</topic><topic>Tumors</topic><topic>Tumors of the urinary system</topic><topic>U-Plasminogen activator</topic><topic>Urinary Bladder Neoplasms - genetics</topic><topic>Urinary system involvement in other diseases. Miscellaneous</topic><topic>Urinary tract. 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The effect on global expression patterns was assessed using cDNA microarrays. The cell clone with the lowest level of DBC1 expression showed induced expression of 26 genes including plasminogen activator inhibitor 2 (SERPINB5; 4.6-fold), heparin-binding EGF-like growth factor precursor (DTR; 4.2-fold), small proline-rich protein 2B (SPRR2B; 3.6-fold), metallothionein 1 isoforms (MT1B/MT1A/MT-1F; from 2.9- to 3.2-fold), tissue-type plasminogen activator precursor (PLAT; 2.8-fold) and urokinase-type plasminogen activator precursor (PLAU; 2.7-fold). In clustering analysis, both PLAT and PLAU clustered with the functionally related urokinase plasminogen activator surface receptor (PLAUR; 1.9-fold). Furthermore, 14 human bladder tumours were analysed by real-time quantitative PCR using gene-specific primers for selected (n=20) genes. 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| language | eng |
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| source | MEDLINE; Nature; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Biological and medical sciences Bladder cancer Cancer Cell Line, Tumor Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Chromosome 9 Conserved sequence DNA microarrays Fundamental and applied biological sciences. Psychology Gene expression Gene Expression Profiling Gene Expression Regulation, Neoplastic Genes Genes, Tumor Suppressor Heparin Humans Isoforms Matrix Metalloproteinases - genetics Matrix Metalloproteinases, Membrane-Associated Medical sciences Metallothionein Molecular and cellular biology Multigene Family Nephrology. Urinary tract diseases Oligonucleotide Array Sequence Analysis Oncology Plasminogen activator inhibitors Polymerase Chain Reaction Proline Protein folding Proteins Receptors, Cell Surface - genetics Receptors, Retinoic Acid - genetics Receptors, Urokinase Plasminogen Activator Serpins - genetics Signal transduction Tissue Plasminogen Activator - genetics Tumor suppressor genes Tumor Suppressor Proteins - genetics Tumor Suppressor Proteins - physiology Tumors Tumors of the urinary system U-Plasminogen activator Urinary Bladder Neoplasms - genetics Urinary system involvement in other diseases. Miscellaneous Urinary tract. Prostate gland Urokinase-Type Plasminogen Activator - genetics |
| title | DBC1 re-expression alters the expression of multiple components of the plasminogen pathway |
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