Arsenic trioxide inhibits DNA methyltransferase and restores methylation-silenced genes in human liver cancer cells

In the present study, we investigated methylation status of the CpG islands of some major tumor suppressor genes both in human hepatocellular carcinoma and liver cancer cell lines and examined whether demethylation by arsenic trioxide (As 2O 3) could restore their expression in the cell lines. HepG2...

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Veröffentlicht in:	Human pathology 2006-03, Vol.37 (3), p.298-311
Hauptverfasser:	Cui, Xing, Wakai, Toshifumi, Shirai, Yoshio, Yokoyama, Naoyuki, Hatakeyama, Katsuyoshi, Hirano, Seishiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Antineoplastic Agents - pharmacology Arsenic Arsenic Trioxide Arsenicals - pharmacology Arsenite Biological and medical sciences Cadherins - genetics Cancer Carcinoma, Hepatocellular - drug therapy Carcinoma, Hepatocellular - enzymology Carcinoma, Hepatocellular - genetics Cell Line, Tumor DNA (Cytosine-5-)-Methyltransferases - antagonists & inhibitors DNA (Cytosine-5-)-Methyltransferases - metabolism DNA demethylation DNA methylation DNA Methylation - drug effects Dose-Response Relationship, Drug Enzyme Inhibitors - pharmacology Epigenetics Female Gastroenterology. Liver. Pancreas. Abdomen Gene Expression Regulation, Neoplastic - drug effects Gene reactivation Gene Silencing - drug effects Genes Genes, Neoplasm - drug effects Genes, p16 - drug effects Genetics Glutathione S-Transferase pi - genetics Hepatocytes - drug effects Hepatocytes - enzymology Hepatocytes - pathology Hepatoma Humans Investigative techniques, diagnostic techniques (general aspects) Liver cancer Liver Neoplasms - drug therapy Liver Neoplasms - enzymology Liver Neoplasms - genetics Liver. Biliary tract. Portal circulation. Exocrine pancreas Male Medical sciences Middle Aged Oxides - pharmacology Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Proteins RNA, Messenger - metabolism Tumor Suppressor Proteins - genetics Tumors
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