Abnormal placental cord insertion may induce intrauterine growth restriction in IVF-twin pregnancies
BACKGROUND: This study determined whether twins conceived through assisted reproduction technology (ART) have an increased risk of perinatal complications compared with natural twin pregnancies and investigated potential associated major risk factors. METHODS: This retrospective study consisted of 1...
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| Veröffentlicht in: | Human reproduction (Oxford) 2006-05, Vol.21 (5), p.1285-1290 |
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| creator | Cai, Li-yi Izumi, Shun-ichiro Koido, Shigeru Uchida, Noa Suzuki, Takahiro Matsubayashi, Hidehiko Sugi, Toshitaka Shida, Nobuko Kikuchi, Kimitaka Yoshikata, Kikuo |
| description | BACKGROUND: This study determined whether twins conceived through assisted reproduction technology (ART) have an increased risk of perinatal complications compared with natural twin pregnancies and investigated potential associated major risk factors. METHODS: This retrospective study consisted of 199 twins born between 1994 and 2003. There were four groups according to conception modalities: 97 twins after spontaneous pregnancy, 24 after induced ovulation, 28 after intrauterine insemination (IUI) and 50 after IVF with embryo transfer. Analysis included preterm birth, Caesarean delivery, weight discordance, intrauterine growth restriction (IUGR), low-birth-weight, Apgar score, chorionicity, gross placental pathology and placental umbilical cord insertion (UCI) site. RESULTS: A significant difference was found in IUGR between the IVF group (7.0%) and spontaneous pregnancy group (14.9%). When maternal age was >30 years there was a 2.86-fold increase in the risk of IUGR. There was a 3.69-fold increased risk of IUGR in the presence of abnormal UCI (odds ratio 3.69, 95% CI 1.62–8.42) and a 2.18-fold increased risk of abnormal UCI in monochorionic twins when compared with dichorionic twins (odds ratio 2.18, 95% CI 1.30–3.66). CONCLUSION: Twins conceived through ART are not at an increased risk of perinatal complications. A relationship has been found between abnormal UCI and IUGR. |
| doi_str_mv | 10.1093/humrep/dei494 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_67857356</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><oup_id>10.1093/humrep/dei494</oup_id><sourcerecordid>67857356</sourcerecordid><originalsourceid>FETCH-LOGICAL-c458t-d886c4ab5886dc5f24a6de586ad1e9fd83c0830ce77f2922104be11307da18953</originalsourceid><addsrcrecordid>eNqF0M1rFjEQB-Agin2tPXqVRVC8rE02m489ltIvecFLldJLyJvMtqm7yZpkafvfm7qLBS-eZgIPM5MfQu8I_kJwRw9v5zHCdGjBtV37Am1Iy3HdUIZfog1uuKwJ4WQPvUnpDuPSSv4a7RHedoJ37QbZo50PcdRDNQ3agM-lMyHayvkEMbvgq1E_lpedDZSSo54zROehuonhPt9WEVKOzvyhzlcXP07rfF-aKcKN1944SG_Rq14PCQ7Wuo--n55cHp_X229nF8dH29q0TObaSslNq3esVGtY37SaW2CSa0ug662kBkuKDQjRN13TENzugBCKhdVEdozuo0_L3CmGX3O5S40uGRgG7SHMSXEhmaCMF_jhH3gX5ujLbaohRJYDaFdQvSATQ0oRejVFN-r4qAhWT9mrJXu1ZF_8-3XovBvBPus17AI-rkAno4c-PqWTnp0QsuwmxX1eXJin_-5cb3Qpw8NfrOPP8lkqmDq_ulayOfvKri87taW_AXXarKs</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>211858839</pqid></control><display><type>article</type><title>Abnormal placental cord insertion may induce intrauterine growth restriction in IVF-twin pregnancies</title><source>MEDLINE</source><source>Oxford University Press Journals All Titles (1996-Current)</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>Cai, Li-yi ; Izumi, Shun-ichiro ; Koido, Shigeru ; Uchida, Noa ; Suzuki, Takahiro ; Matsubayashi, Hidehiko ; Sugi, Toshitaka ; Shida, Nobuko ; Kikuchi, Kimitaka ; Yoshikata, Kikuo</creator><creatorcontrib>Cai, Li-yi ; Izumi, Shun-ichiro ; Koido, Shigeru ; Uchida, Noa ; Suzuki, Takahiro ; Matsubayashi, Hidehiko ; Sugi, Toshitaka ; Shida, Nobuko ; Kikuchi, Kimitaka ; Yoshikata, Kikuo</creatorcontrib><description>BACKGROUND: This study determined whether twins conceived through assisted reproduction technology (ART) have an increased risk of perinatal complications compared with natural twin pregnancies and investigated potential associated major risk factors. METHODS: This retrospective study consisted of 199 twins born between 1994 and 2003. There were four groups according to conception modalities: 97 twins after spontaneous pregnancy, 24 after induced ovulation, 28 after intrauterine insemination (IUI) and 50 after IVF with embryo transfer. Analysis included preterm birth, Caesarean delivery, weight discordance, intrauterine growth restriction (IUGR), low-birth-weight, Apgar score, chorionicity, gross placental pathology and placental umbilical cord insertion (UCI) site. RESULTS: A significant difference was found in IUGR between the IVF group (7.0%) and spontaneous pregnancy group (14.9%). When maternal age was >30 years there was a 2.86-fold increase in the risk of IUGR. There was a 3.69-fold increased risk of IUGR in the presence of abnormal UCI (odds ratio 3.69, 95% CI 1.62–8.42) and a 2.18-fold increased risk of abnormal UCI in monochorionic twins when compared with dichorionic twins (odds ratio 2.18, 95% CI 1.30–3.66). CONCLUSION: Twins conceived through ART are not at an increased risk of perinatal complications. A relationship has been found between abnormal UCI and IUGR.</description><identifier>ISSN: 0268-1161</identifier><identifier>EISSN: 1460-2350</identifier><identifier>DOI: 10.1093/humrep/dei494</identifier><identifier>PMID: 16497694</identifier><identifier>CODEN: HUREEE</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>assisted reproduction technique ; Biological and medical sciences ; Diseases in Twins - epidemiology ; Female ; Fetal Growth Retardation - epidemiology ; Gynecology. Andrology. Obstetrics ; Humans ; intrauterine growth restriction (IUGR) ; IVF ; Medical sciences ; Placenta - abnormalities ; Pregnancy ; Pregnancy Outcome - epidemiology ; Pregnancy, Multiple - physiology ; Reproductive Techniques, Assisted ; Risk Factors ; twins ; Twins, Dizygotic - physiology ; Twins, Monozygotic - physiology ; Umbilical Cord - abnormalities ; umbilical cord insertion</subject><ispartof>Human reproduction (Oxford), 2006-05, Vol.21 (5), p.1285-1290</ispartof><rights>The Author 2006. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org 2006</rights><rights>2006 INIST-CNRS</rights><rights>Copyright Oxford University Press(England) May 2006</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c458t-d886c4ab5886dc5f24a6de586ad1e9fd83c0830ce77f2922104be11307da18953</citedby><cites>FETCH-LOGICAL-c458t-d886c4ab5886dc5f24a6de586ad1e9fd83c0830ce77f2922104be11307da18953</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1578,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17781851$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16497694$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cai, Li-yi</creatorcontrib><creatorcontrib>Izumi, Shun-ichiro</creatorcontrib><creatorcontrib>Koido, Shigeru</creatorcontrib><creatorcontrib>Uchida, Noa</creatorcontrib><creatorcontrib>Suzuki, Takahiro</creatorcontrib><creatorcontrib>Matsubayashi, Hidehiko</creatorcontrib><creatorcontrib>Sugi, Toshitaka</creatorcontrib><creatorcontrib>Shida, Nobuko</creatorcontrib><creatorcontrib>Kikuchi, Kimitaka</creatorcontrib><creatorcontrib>Yoshikata, Kikuo</creatorcontrib><title>Abnormal placental cord insertion may induce intrauterine growth restriction in IVF-twin pregnancies</title><title>Human reproduction (Oxford)</title><addtitle>Hum. Reprod</addtitle><addtitle>Hum. Reprod</addtitle><description>BACKGROUND: This study determined whether twins conceived through assisted reproduction technology (ART) have an increased risk of perinatal complications compared with natural twin pregnancies and investigated potential associated major risk factors. METHODS: This retrospective study consisted of 199 twins born between 1994 and 2003. There were four groups according to conception modalities: 97 twins after spontaneous pregnancy, 24 after induced ovulation, 28 after intrauterine insemination (IUI) and 50 after IVF with embryo transfer. Analysis included preterm birth, Caesarean delivery, weight discordance, intrauterine growth restriction (IUGR), low-birth-weight, Apgar score, chorionicity, gross placental pathology and placental umbilical cord insertion (UCI) site. RESULTS: A significant difference was found in IUGR between the IVF group (7.0%) and spontaneous pregnancy group (14.9%). When maternal age was >30 years there was a 2.86-fold increase in the risk of IUGR. There was a 3.69-fold increased risk of IUGR in the presence of abnormal UCI (odds ratio 3.69, 95% CI 1.62–8.42) and a 2.18-fold increased risk of abnormal UCI in monochorionic twins when compared with dichorionic twins (odds ratio 2.18, 95% CI 1.30–3.66). CONCLUSION: Twins conceived through ART are not at an increased risk of perinatal complications. A relationship has been found between abnormal UCI and IUGR.</description><subject>assisted reproduction technique</subject><subject>Biological and medical sciences</subject><subject>Diseases in Twins - epidemiology</subject><subject>Female</subject><subject>Fetal Growth Retardation - epidemiology</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>intrauterine growth restriction (IUGR)</subject><subject>IVF</subject><subject>Medical sciences</subject><subject>Placenta - abnormalities</subject><subject>Pregnancy</subject><subject>Pregnancy Outcome - epidemiology</subject><subject>Pregnancy, Multiple - physiology</subject><subject>Reproductive Techniques, Assisted</subject><subject>Risk Factors</subject><subject>twins</subject><subject>Twins, Dizygotic - physiology</subject><subject>Twins, Monozygotic - physiology</subject><subject>Umbilical Cord - abnormalities</subject><subject>umbilical cord insertion</subject><issn>0268-1161</issn><issn>1460-2350</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0M1rFjEQB-Agin2tPXqVRVC8rE02m489ltIvecFLldJLyJvMtqm7yZpkafvfm7qLBS-eZgIPM5MfQu8I_kJwRw9v5zHCdGjBtV37Am1Iy3HdUIZfog1uuKwJ4WQPvUnpDuPSSv4a7RHedoJ37QbZo50PcdRDNQ3agM-lMyHayvkEMbvgq1E_lpedDZSSo54zROehuonhPt9WEVKOzvyhzlcXP07rfF-aKcKN1944SG_Rq14PCQ7Wuo--n55cHp_X229nF8dH29q0TObaSslNq3esVGtY37SaW2CSa0ug662kBkuKDQjRN13TENzugBCKhdVEdozuo0_L3CmGX3O5S40uGRgG7SHMSXEhmaCMF_jhH3gX5ujLbaohRJYDaFdQvSATQ0oRejVFN-r4qAhWT9mrJXu1ZF_8-3XovBvBPus17AI-rkAno4c-PqWTnp0QsuwmxX1eXJin_-5cb3Qpw8NfrOPP8lkqmDq_ulayOfvKri87taW_AXXarKs</recordid><startdate>20060501</startdate><enddate>20060501</enddate><creator>Cai, Li-yi</creator><creator>Izumi, Shun-ichiro</creator><creator>Koido, Shigeru</creator><creator>Uchida, Noa</creator><creator>Suzuki, Takahiro</creator><creator>Matsubayashi, Hidehiko</creator><creator>Sugi, Toshitaka</creator><creator>Shida, Nobuko</creator><creator>Kikuchi, Kimitaka</creator><creator>Yoshikata, Kikuo</creator><general>Oxford University Press</general><general>Oxford Publishing Limited (England)</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TM</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20060501</creationdate><title>Abnormal placental cord insertion may induce intrauterine growth restriction in IVF-twin pregnancies</title><author>Cai, Li-yi ; Izumi, Shun-ichiro ; Koido, Shigeru ; Uchida, Noa ; Suzuki, Takahiro ; Matsubayashi, Hidehiko ; Sugi, Toshitaka ; Shida, Nobuko ; Kikuchi, Kimitaka ; Yoshikata, Kikuo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c458t-d886c4ab5886dc5f24a6de586ad1e9fd83c0830ce77f2922104be11307da18953</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>assisted reproduction technique</topic><topic>Biological and medical sciences</topic><topic>Diseases in Twins - epidemiology</topic><topic>Female</topic><topic>Fetal Growth Retardation - epidemiology</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>intrauterine growth restriction (IUGR)</topic><topic>IVF</topic><topic>Medical sciences</topic><topic>Placenta - abnormalities</topic><topic>Pregnancy</topic><topic>Pregnancy Outcome - epidemiology</topic><topic>Pregnancy, Multiple - physiology</topic><topic>Reproductive Techniques, Assisted</topic><topic>Risk Factors</topic><topic>twins</topic><topic>Twins, Dizygotic - physiology</topic><topic>Twins, Monozygotic - physiology</topic><topic>Umbilical Cord - abnormalities</topic><topic>umbilical cord insertion</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cai, Li-yi</creatorcontrib><creatorcontrib>Izumi, Shun-ichiro</creatorcontrib><creatorcontrib>Koido, Shigeru</creatorcontrib><creatorcontrib>Uchida, Noa</creatorcontrib><creatorcontrib>Suzuki, Takahiro</creatorcontrib><creatorcontrib>Matsubayashi, Hidehiko</creatorcontrib><creatorcontrib>Sugi, Toshitaka</creatorcontrib><creatorcontrib>Shida, Nobuko</creatorcontrib><creatorcontrib>Kikuchi, Kimitaka</creatorcontrib><creatorcontrib>Yoshikata, Kikuo</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Human reproduction (Oxford)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cai, Li-yi</au><au>Izumi, Shun-ichiro</au><au>Koido, Shigeru</au><au>Uchida, Noa</au><au>Suzuki, Takahiro</au><au>Matsubayashi, Hidehiko</au><au>Sugi, Toshitaka</au><au>Shida, Nobuko</au><au>Kikuchi, Kimitaka</au><au>Yoshikata, Kikuo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Abnormal placental cord insertion may induce intrauterine growth restriction in IVF-twin pregnancies</atitle><jtitle>Human reproduction (Oxford)</jtitle><stitle>Hum. Reprod</stitle><addtitle>Hum. Reprod</addtitle><date>2006-05-01</date><risdate>2006</risdate><volume>21</volume><issue>5</issue><spage>1285</spage><epage>1290</epage><pages>1285-1290</pages><issn>0268-1161</issn><eissn>1460-2350</eissn><coden>HUREEE</coden><abstract>BACKGROUND: This study determined whether twins conceived through assisted reproduction technology (ART) have an increased risk of perinatal complications compared with natural twin pregnancies and investigated potential associated major risk factors. METHODS: This retrospective study consisted of 199 twins born between 1994 and 2003. There were four groups according to conception modalities: 97 twins after spontaneous pregnancy, 24 after induced ovulation, 28 after intrauterine insemination (IUI) and 50 after IVF with embryo transfer. Analysis included preterm birth, Caesarean delivery, weight discordance, intrauterine growth restriction (IUGR), low-birth-weight, Apgar score, chorionicity, gross placental pathology and placental umbilical cord insertion (UCI) site. RESULTS: A significant difference was found in IUGR between the IVF group (7.0%) and spontaneous pregnancy group (14.9%). When maternal age was >30 years there was a 2.86-fold increase in the risk of IUGR. There was a 3.69-fold increased risk of IUGR in the presence of abnormal UCI (odds ratio 3.69, 95% CI 1.62–8.42) and a 2.18-fold increased risk of abnormal UCI in monochorionic twins when compared with dichorionic twins (odds ratio 2.18, 95% CI 1.30–3.66). CONCLUSION: Twins conceived through ART are not at an increased risk of perinatal complications. A relationship has been found between abnormal UCI and IUGR.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>16497694</pmid><doi>10.1093/humrep/dei494</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | assisted reproduction technique Biological and medical sciences Diseases in Twins - epidemiology Female Fetal Growth Retardation - epidemiology Gynecology. Andrology. Obstetrics Humans intrauterine growth restriction (IUGR) IVF Medical sciences Placenta - abnormalities Pregnancy Pregnancy Outcome - epidemiology Pregnancy, Multiple - physiology Reproductive Techniques, Assisted Risk Factors twins Twins, Dizygotic - physiology Twins, Monozygotic - physiology Umbilical Cord - abnormalities umbilical cord insertion |
| title | Abnormal placental cord insertion may induce intrauterine growth restriction in IVF-twin pregnancies |
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