Roux-en-Y gastric bypass versus a variant of biliopancreatic diversion in a non-superobese population: prospective comparison of the efficacy and the incidence of metabolic deficiencies
In the non-superobese population, an agreement has not been made as to the optimal bariatric operation. The present study reports the results of a prospective comparison of Roux-en-Y gastric bypass (RYGBP) and a variant of biliopancreatic diversion (BPD) in a non-superobese population. From a cohort...
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| Veröffentlicht in: | Obesity surgery 2006-04, Vol.16 (4), p.488-495 |
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| creator | Skroubis, George Anesidis, Stathis Kehagias, Ioannis Mead, Nancy Vagenas, Kostas Kalfarentzos, Fotis |
| description | In the non-superobese population, an agreement has not been made as to the optimal bariatric operation. The present study reports the results of a prospective comparison of Roux-en-Y gastric bypass (RYGBP) and a variant of biliopancreatic diversion (BPD) in a non-superobese population.
From a cohort of 130 patients with BMI 35 to 50 kg/m(2), 65 patients were randomly selected to undergo RYGBP and 65 to undergo BPD. All patients underwent complete follow-up evaluation at 1, 3, 6, and 12 months postoperatively and every year thereafter.
Patients in both groups have completed their second postoperative year. Mean % excess weight loss (%EWL) was significantly better after BPD at all time periods (12 months, P=0.0001 and 24 months, P=0.0003), and the %EWL was >50% in all BPD patients compared to 88.7% in the RYGBP patients at 2-year follow-up. No statistically significant differences were observed between the 2 groups in early and late non-metabolic complications. Hypoalbuminemia occurred in only 1 patient (1.5%) after RYGBP and in 6 patients after BPD (9.2%). Only 1 patient from each group was hospitalized and received total parenteral nutrition. Glucose intolerance, hypercholesterolemia, hypertriglyceridemia and sleep apnea completely resolved in all patients in both groups, although mean total cholesterol level was significantly lower in BPD patients at the second year follow-up (t-test, P |
| doi_str_mv | 10.1381/096089206776327251 |
| format | Article |
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From a cohort of 130 patients with BMI 35 to 50 kg/m(2), 65 patients were randomly selected to undergo RYGBP and 65 to undergo BPD. All patients underwent complete follow-up evaluation at 1, 3, 6, and 12 months postoperatively and every year thereafter.
Patients in both groups have completed their second postoperative year. Mean % excess weight loss (%EWL) was significantly better after BPD at all time periods (12 months, P=0.0001 and 24 months, P=0.0003), and the %EWL was >50% in all BPD patients compared to 88.7% in the RYGBP patients at 2-year follow-up. No statistically significant differences were observed between the 2 groups in early and late non-metabolic complications. Hypoalbuminemia occurred in only 1 patient (1.5%) after RYGBP and in 6 patients after BPD (9.2%). Only 1 patient from each group was hospitalized and received total parenteral nutrition. Glucose intolerance, hypercholesterolemia, hypertriglyceridemia and sleep apnea completely resolved in all patients in both groups, although mean total cholesterol level was significantly lower in BPD patients at the second year follow-up (t-test, P<0.0001). Diabetes completely resolved in all BPD patients and in 7 of the 10 diabetic RYGBP patients.
Both RYGBP and BPD were safe and effective procedures when offered to non-superobese patients. Weight loss after BPD was consistently better than that after RYGBP, as was the resolution of diabetes and hypercholesterolemia. Because the nutritional deficiencies that occurred following this type of BPD were not severe and were not significantly different between the 2 operations, both may be offered to non-superobese patients, keeping in mind the severity and type of preoperative co-morbidities as well as the desired weight loss.</description><identifier>ISSN: 0960-8923</identifier><identifier>EISSN: 1708-0428</identifier><identifier>DOI: 10.1381/096089206776327251</identifier><identifier>PMID: 16608616</identifier><language>eng</language><publisher>United States: Springer Nature B.V</publisher><subject>Adult ; Alkaline Phosphatase - blood ; Anemia - epidemiology ; Biliopancreatic Diversion - adverse effects ; Biliopancreatic Diversion - methods ; Blood Glucose - analysis ; Calcium - blood ; Comorbidity ; Female ; Gastric Bypass - adverse effects ; Gastric Bypass - methods ; Humans ; Hypercholesterolemia - epidemiology ; Hypertriglyceridemia - epidemiology ; Hypoalbuminemia - epidemiology ; Magnesium - blood ; Male ; Metabolic Diseases - etiology ; Nutrition ; Obesity, Morbid - epidemiology ; Obesity, Morbid - metabolism ; Obesity, Morbid - surgery ; Phosphorus - blood ; Prospective Studies ; Sleep Apnea Syndromes - epidemiology ; Weight control</subject><ispartof>Obesity surgery, 2006-04, Vol.16 (4), p.488-495</ispartof><rights>Springer 2006</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c394t-5b72fb6b252eeadd80638ecaed63e0efb8b8e873d2db20ac4ed8371866d6efd33</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16608616$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Skroubis, George</creatorcontrib><creatorcontrib>Anesidis, Stathis</creatorcontrib><creatorcontrib>Kehagias, Ioannis</creatorcontrib><creatorcontrib>Mead, Nancy</creatorcontrib><creatorcontrib>Vagenas, Kostas</creatorcontrib><creatorcontrib>Kalfarentzos, Fotis</creatorcontrib><title>Roux-en-Y gastric bypass versus a variant of biliopancreatic diversion in a non-superobese population: prospective comparison of the efficacy and the incidence of metabolic deficiencies</title><title>Obesity surgery</title><addtitle>Obes Surg</addtitle><description>In the non-superobese population, an agreement has not been made as to the optimal bariatric operation. The present study reports the results of a prospective comparison of Roux-en-Y gastric bypass (RYGBP) and a variant of biliopancreatic diversion (BPD) in a non-superobese population.
From a cohort of 130 patients with BMI 35 to 50 kg/m(2), 65 patients were randomly selected to undergo RYGBP and 65 to undergo BPD. All patients underwent complete follow-up evaluation at 1, 3, 6, and 12 months postoperatively and every year thereafter.
Patients in both groups have completed their second postoperative year. Mean % excess weight loss (%EWL) was significantly better after BPD at all time periods (12 months, P=0.0001 and 24 months, P=0.0003), and the %EWL was >50% in all BPD patients compared to 88.7% in the RYGBP patients at 2-year follow-up. No statistically significant differences were observed between the 2 groups in early and late non-metabolic complications. Hypoalbuminemia occurred in only 1 patient (1.5%) after RYGBP and in 6 patients after BPD (9.2%). Only 1 patient from each group was hospitalized and received total parenteral nutrition. Glucose intolerance, hypercholesterolemia, hypertriglyceridemia and sleep apnea completely resolved in all patients in both groups, although mean total cholesterol level was significantly lower in BPD patients at the second year follow-up (t-test, P<0.0001). Diabetes completely resolved in all BPD patients and in 7 of the 10 diabetic RYGBP patients.
Both RYGBP and BPD were safe and effective procedures when offered to non-superobese patients. Weight loss after BPD was consistently better than that after RYGBP, as was the resolution of diabetes and hypercholesterolemia. Because the nutritional deficiencies that occurred following this type of BPD were not severe and were not significantly different between the 2 operations, both may be offered to non-superobese patients, keeping in mind the severity and type of preoperative co-morbidities as well as the desired weight loss.</description><subject>Adult</subject><subject>Alkaline Phosphatase - blood</subject><subject>Anemia - epidemiology</subject><subject>Biliopancreatic Diversion - adverse effects</subject><subject>Biliopancreatic Diversion - methods</subject><subject>Blood Glucose - analysis</subject><subject>Calcium - blood</subject><subject>Comorbidity</subject><subject>Female</subject><subject>Gastric Bypass - adverse effects</subject><subject>Gastric Bypass - methods</subject><subject>Humans</subject><subject>Hypercholesterolemia - epidemiology</subject><subject>Hypertriglyceridemia - epidemiology</subject><subject>Hypoalbuminemia - epidemiology</subject><subject>Magnesium - blood</subject><subject>Male</subject><subject>Metabolic Diseases - etiology</subject><subject>Nutrition</subject><subject>Obesity, Morbid - epidemiology</subject><subject>Obesity, Morbid - metabolism</subject><subject>Obesity, Morbid - surgery</subject><subject>Phosphorus - blood</subject><subject>Prospective Studies</subject><subject>Sleep Apnea Syndromes - epidemiology</subject><subject>Weight control</subject><issn>0960-8923</issn><issn>1708-0428</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNplkcuKFDEUhoMoTjv6Ai4kuHBXmktXknYnw-gMDAiiC1dFLqc0Q1USk6rBfjTfzlNOg6CrwOH7_iTnJ-Q5Z6-5NPwNOyhmDoIprZUUWvT8AdlxzUzH9sI8JLsN6JCQZ-RJa7eMCa6EeEzOuEJTcbUjvz7l9WcHqftKv9m21OipOxbbGr2D2tZGLb2zNdq00DxSF6eYi02-gl0QDXGjYk40JiRTTl1bC9TsoAEtuawTcjm9paXmVsAvKFCf54KZDTXMXL4DhXGM3vojtSn8GcTkY4DkYSNmWKzL03YfIBdxHqE9JY9GOzV4djrPyZf3l58vrrqbjx-uL97ddF4e9kvXOy1Gp5zoBYANwTAlDXgLQUlgMDrjDBgtgwhOMOv3EIzU3CgVFIxBynPy6j4Xv_BjhbYMc2wepskmyGsblDa9xvUj-PIf8DavNeHbBiM4Z_KgeoTEPeRxIa3COJQaZ1uPA2fD1urwf6sovTglr26G8Fc51Sh_Az12okg</recordid><startdate>200604</startdate><enddate>200604</enddate><creator>Skroubis, George</creator><creator>Anesidis, Stathis</creator><creator>Kehagias, Ioannis</creator><creator>Mead, Nancy</creator><creator>Vagenas, Kostas</creator><creator>Kalfarentzos, Fotis</creator><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope></search><sort><creationdate>200604</creationdate><title>Roux-en-Y gastric bypass versus a variant of biliopancreatic diversion in a non-superobese population: prospective comparison of the efficacy and the incidence of metabolic deficiencies</title><author>Skroubis, George ; Anesidis, Stathis ; Kehagias, Ioannis ; Mead, Nancy ; Vagenas, Kostas ; Kalfarentzos, Fotis</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c394t-5b72fb6b252eeadd80638ecaed63e0efb8b8e873d2db20ac4ed8371866d6efd33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Adult</topic><topic>Alkaline Phosphatase - blood</topic><topic>Anemia - epidemiology</topic><topic>Biliopancreatic Diversion - adverse effects</topic><topic>Biliopancreatic Diversion - methods</topic><topic>Blood Glucose - analysis</topic><topic>Calcium - blood</topic><topic>Comorbidity</topic><topic>Female</topic><topic>Gastric Bypass - adverse effects</topic><topic>Gastric Bypass - methods</topic><topic>Humans</topic><topic>Hypercholesterolemia - epidemiology</topic><topic>Hypertriglyceridemia - epidemiology</topic><topic>Hypoalbuminemia - epidemiology</topic><topic>Magnesium - blood</topic><topic>Male</topic><topic>Metabolic Diseases - etiology</topic><topic>Nutrition</topic><topic>Obesity, Morbid - epidemiology</topic><topic>Obesity, Morbid - metabolism</topic><topic>Obesity, Morbid - surgery</topic><topic>Phosphorus - blood</topic><topic>Prospective Studies</topic><topic>Sleep Apnea Syndromes - epidemiology</topic><topic>Weight control</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Skroubis, George</creatorcontrib><creatorcontrib>Anesidis, Stathis</creatorcontrib><creatorcontrib>Kehagias, Ioannis</creatorcontrib><creatorcontrib>Mead, Nancy</creatorcontrib><creatorcontrib>Vagenas, Kostas</creatorcontrib><creatorcontrib>Kalfarentzos, Fotis</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>Obesity surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Skroubis, George</au><au>Anesidis, Stathis</au><au>Kehagias, Ioannis</au><au>Mead, Nancy</au><au>Vagenas, Kostas</au><au>Kalfarentzos, Fotis</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Roux-en-Y gastric bypass versus a variant of biliopancreatic diversion in a non-superobese population: prospective comparison of the efficacy and the incidence of metabolic deficiencies</atitle><jtitle>Obesity surgery</jtitle><addtitle>Obes Surg</addtitle><date>2006-04</date><risdate>2006</risdate><volume>16</volume><issue>4</issue><spage>488</spage><epage>495</epage><pages>488-495</pages><issn>0960-8923</issn><eissn>1708-0428</eissn><abstract>In the non-superobese population, an agreement has not been made as to the optimal bariatric operation. The present study reports the results of a prospective comparison of Roux-en-Y gastric bypass (RYGBP) and a variant of biliopancreatic diversion (BPD) in a non-superobese population.
From a cohort of 130 patients with BMI 35 to 50 kg/m(2), 65 patients were randomly selected to undergo RYGBP and 65 to undergo BPD. All patients underwent complete follow-up evaluation at 1, 3, 6, and 12 months postoperatively and every year thereafter.
Patients in both groups have completed their second postoperative year. Mean % excess weight loss (%EWL) was significantly better after BPD at all time periods (12 months, P=0.0001 and 24 months, P=0.0003), and the %EWL was >50% in all BPD patients compared to 88.7% in the RYGBP patients at 2-year follow-up. No statistically significant differences were observed between the 2 groups in early and late non-metabolic complications. Hypoalbuminemia occurred in only 1 patient (1.5%) after RYGBP and in 6 patients after BPD (9.2%). Only 1 patient from each group was hospitalized and received total parenteral nutrition. Glucose intolerance, hypercholesterolemia, hypertriglyceridemia and sleep apnea completely resolved in all patients in both groups, although mean total cholesterol level was significantly lower in BPD patients at the second year follow-up (t-test, P<0.0001). Diabetes completely resolved in all BPD patients and in 7 of the 10 diabetic RYGBP patients.
Both RYGBP and BPD were safe and effective procedures when offered to non-superobese patients. Weight loss after BPD was consistently better than that after RYGBP, as was the resolution of diabetes and hypercholesterolemia. Because the nutritional deficiencies that occurred following this type of BPD were not severe and were not significantly different between the 2 operations, both may be offered to non-superobese patients, keeping in mind the severity and type of preoperative co-morbidities as well as the desired weight loss.</abstract><cop>United States</cop><pub>Springer Nature B.V</pub><pmid>16608616</pmid><doi>10.1381/096089206776327251</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0960-8923 |
| ispartof | Obesity surgery, 2006-04, Vol.16 (4), p.488-495 |
| issn | 0960-8923 1708-0428 |
| language | eng |
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| source | MEDLINE; SpringerLink Journals |
| subjects | Adult Alkaline Phosphatase - blood Anemia - epidemiology Biliopancreatic Diversion - adverse effects Biliopancreatic Diversion - methods Blood Glucose - analysis Calcium - blood Comorbidity Female Gastric Bypass - adverse effects Gastric Bypass - methods Humans Hypercholesterolemia - epidemiology Hypertriglyceridemia - epidemiology Hypoalbuminemia - epidemiology Magnesium - blood Male Metabolic Diseases - etiology Nutrition Obesity, Morbid - epidemiology Obesity, Morbid - metabolism Obesity, Morbid - surgery Phosphorus - blood Prospective Studies Sleep Apnea Syndromes - epidemiology Weight control |
| title | Roux-en-Y gastric bypass versus a variant of biliopancreatic diversion in a non-superobese population: prospective comparison of the efficacy and the incidence of metabolic deficiencies |
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