Altered Nuclear Receptor Corepressor Expression Attenuates Vitamin D Receptor Signaling in Breast Cancer Cells

Purpose: We hypothesized that deregulated corepressor actions, with associated histone deacetylation activity, epigenetically suppressed vitamin D receptor (VDR) responsiveness and drives resistance towards 1α,25-dihydroxyvitamin D 3 . Experimental Design: Profiling, transcriptional, and proliferati...

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Veröffentlicht in:	Clinical cancer research 2006-04, Vol.12 (7), p.2004-2013
Hauptverfasser:	BANWELL, Claire M, MACCARTNEY, Donia P, CAMPBELL, Moray J, GUY, Michelle, MILES, Alice E, USKOKOVIC, Milan R, MANSI, Janine, STEWART, Paul M, O'NEILL, Laura P, TURNER, Bryan M, COLSTON, Kay W
Format:	Artikel
Sprache:	eng
Schlagworte:	1α,25-Dihydroxyvitamin D Antineoplastic agents Azacitidine - analogs & derivatives Azacitidine - pharmacology Biological and medical sciences breast cancer Breast Neoplasms - metabolism Calcitriol - pharmacology Cell Cycle - drug effects Cell Line, Tumor Cell Proliferation - drug effects Cholecalciferol - analogs & derivatives Cholecalciferol - pharmacology Female GADD45α Gynecology. Andrology. Obstetrics Histone deacetylation inhibitors Humans Hydroxamic Acids - pharmacology Mammary gland diseases Medical sciences Nuclear Proteins - drug effects Nuclear Proteins - genetics Nuclear Proteins - metabolism Nuclear Receptor Co-Repressor 1 Nuclear receptor corepressor Pharmacology. Drug treatments Receptors, Calcitriol - drug effects Receptors, Calcitriol - metabolism Repressor Proteins - drug effects Repressor Proteins - genetics Repressor Proteins - metabolism Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - drug effects RNA, Messenger - genetics Signal Transduction - drug effects Structure-Activity Relationship Time Factors Tumor Cells, Cultured Tumors VDUP-1
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