Generation of a mouse with conditionally activated signaling through the BMP receptor, ALK2

BMP signaling plays pleiotropic roles in various tissues. Transgenic mouse lines that overexpress BMP signaling in a tissue‐specific manner would be beneficial; however, production of each tissue‐specific transgenic mouse line is labor‐intensive. Here, using a Cre‐loxP system, we generated a conditi...

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Veröffentlicht in:	Genesis (New York, N.Y. : 2000) N.Y. : 2000), 2006-04, Vol.44 (4), p.159-167
Hauptverfasser:	Fukuda, Tomokazu, Scott, Gregory, Komatsu, Yoshihiro, Araya, Runa, Kawano, Masako, Ray, Manas K., Yamada, Masahisa, Mishina, Yuji
Format:	Artikel
Sprache:	eng
Schlagworte:	Activin Receptors, Type I - genetics Activin Receptors, Type I - metabolism Adenoviridae - genetics Animals bone morphogenetic protein Bone Morphogenetic Protein Receptors - metabolism constitutively active Cre-loxP system Crosses, Genetic Female Gene Expression Regulation, Developmental Green Fluorescent Proteins - metabolism Integrases - genetics Integrases - metabolism Male Mice Mice, Transgenic Models, Genetic Promoter Regions, Genetic Recombination, Genetic Signal Transduction Smad Transgenes transgenic mouse
Online-Zugang:	Volltext
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