Synthetic modification of the 2-oxypropionic acid moiety in 2-{4-[(7-chloro-2-quinoxalinyl)oxy]phenoxy}propionic acid (XK469), and consequent antitumor effects. Part 4

[Display omitted] The criteria for the activity of 2-{4-[(7-chloro-2-quinoxalinyl)oxy]phenoxy}propionic acid (XK469) and 2-{4-[(7-bromo-2-quinolinyl)oxy]phenoxy}propionic acid (SH80) against transplanted tumors in mice established in previous studies, require a (7-halo-2-quinoxalinoxy)- or a (7-halo...

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Veröffentlicht in:	Bioorganic & medicinal chemistry 2005-06, Vol.13 (12), p.3910-3920
Hauptverfasser:	Hazeldine, Stuart T., Polin, Lisa, Kushner, Juiwanna, White, Kathryn, Corbett, Thomas H., Horwitz, Jerome P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Analogs Animals Antineoplastic agents Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Antitumor Biological and medical sciences Cell Proliferation - drug effects Drug Screening Assays, Antitumor Fluorine General aspects Humans Medical sciences Methylation Mice Pharmacology. Drug treatments Propionates Quinoxalines - chemistry Quinoxalines - pharmacology SH80 Structure-Activity Relationship Tumor Cells, Cultured Xenograft Model Antitumor Assays XK469
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