Myostatin, a negative regulator of muscle mass: implications for muscle degenerative diseases

Myostatin is a secreted protein that negatively regulates skeletal muscle mass determining both muscle fiber number and size. The myostatin pathway is conserved and regulates muscle mass in a number of animal species ranging from fish to humans. Inhibition of myostatin using a variety of therapeutic...

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Veröffentlicht in:	Current opinion in pharmacology 2005-06, Vol.5 (3), p.328-332
Hauptverfasser:	Tobin, James F, Celeste, Anthony J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Humans Muscular Diseases - physiopathology Muscular Diseases - therapy Myostatin Signal Transduction - drug effects Signal Transduction - physiology Transforming Growth Factor beta - adverse effects Transforming Growth Factor beta - antagonists & inhibitors Transforming Growth Factor beta - physiology
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