Myostatin, a negative regulator of muscle mass: implications for muscle degenerative diseases
Myostatin is a secreted protein that negatively regulates skeletal muscle mass determining both muscle fiber number and size. The myostatin pathway is conserved and regulates muscle mass in a number of animal species ranging from fish to humans. Inhibition of myostatin using a variety of therapeutic...
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| Veröffentlicht in: | Current opinion in pharmacology 2005-06, Vol.5 (3), p.328-332 |
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| container_title | Current opinion in pharmacology |
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| creator | Tobin, James F Celeste, Anthony J |
| description | Myostatin is a secreted protein that negatively regulates skeletal muscle mass determining both muscle fiber number and size. The myostatin pathway is conserved and regulates muscle mass in a number of animal species ranging from fish to humans. Inhibition of myostatin using a variety of therapeutic approaches can increase muscle mass in a number of animal models of human disease, including muscular dystrophy. |
| doi_str_mv | 10.1016/j.coph.2005.01.011 |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 1471-4892 |
| ispartof | Current opinion in pharmacology, 2005-06, Vol.5 (3), p.328-332 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Animals Humans Muscular Diseases - physiopathology Muscular Diseases - therapy Myostatin Signal Transduction - drug effects Signal Transduction - physiology Transforming Growth Factor beta - adverse effects Transforming Growth Factor beta - antagonists & inhibitors Transforming Growth Factor beta - physiology |
| title | Myostatin, a negative regulator of muscle mass: implications for muscle degenerative diseases |
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