Innate Immune Collectin Surfactant Protein D Enhances the Clearance of DNA by Macrophages and Minimizes Anti-DNA Antibody Generation

Dying microbes and necrotic cells release highly viscous DNA that induces inflammation and septic shock, and apoptotic cells display DNA, a potential autoantigen, on their surfaces. However, innate immune proteins that mediate the clearance of free DNA and surface DNA-containing cells are not clearl...

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Veröffentlicht in:	The Journal of immunology (1950) 2005-06, Vol.174 (11), p.7352-7358
Hauptverfasser:	Palaniyar, Nades, Clark, Howard, Nadesalingam, Jeya, Shih, Michael J, Hawgood, Samuel, Reid, Kenneth B. M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvants, Immunologic - deficiency Adjuvants, Immunologic - genetics Adjuvants, Immunologic - metabolism Adjuvants, Immunologic - physiology Animals Antibodies, Antinuclear - biosynthesis Antibodies, Antinuclear - blood Autoantigens - immunology Autoantigens - metabolism DNA - immunology DNA - metabolism Humans Immunity, Innate - genetics Lung - immunology Lung - metabolism Macrophages - immunology Macrophages - metabolism Mice Mice, Inbred C57BL Mice, Knockout Pinocytosis - genetics Pinocytosis - immunology Plasmids - metabolism Pulmonary Surfactant-Associated Protein A - deficiency Pulmonary Surfactant-Associated Protein A - genetics Pulmonary Surfactant-Associated Protein D - deficiency Pulmonary Surfactant-Associated Protein D - genetics Pulmonary Surfactant-Associated Protein D - metabolism Pulmonary Surfactant-Associated Protein D - physiology U937 Cells
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