Overexpression of Aurora-A kinase promotes tumor cell proliferation and inhibits apoptosis in esophageal squamous cell carcinoma cell line

Attrora-A kinase, a serine/threonine protein kinase, is a potential oncogene. Amplification and overexpression of Aurora-A have been found in several types of human tumors, including esophageal squamous cell carcinoma （ESCC）. It has been demonstrated that cells overexpressing Attrora-A are more resi...

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Veröffentlicht in:	Cell research 2006-04, Vol.16 (4), p.356-366
Hauptverfasser:	Wang, Xiao Xia, Liu, Rong, Jin, Shun Qian, Fan, Fei Yue, Zhan, Qi Min
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis - drug effects Apoptosis - radiation effects Apoptosis Regulatory Proteins - genetics Aurora Kinases Biomedical and Life Sciences Caspase 3 Caspases - metabolism Cell Biology Cell Line, Tumor Cell Proliferation Cisplatin - antagonists & inhibitors Esophageal Neoplasms - genetics Humans Irradiation Life Sciences Neoplasms, Squamous Cell - genetics Neoplasms, Squamous Cell - metabolism Neoplastic Stem Cells original-article Poly(ADP-ribose) Polymerases - metabolism Protein-Serine-Threonine Kinases - genetics Protein-Serine-Threonine Kinases - metabolism Proto-Oncogene Proteins c-bcl-2 - genetics Radiation Tolerance - genetics RNA Interference - drug effects RNA Interference - radiation effects RNA, Small Interfering - drug effects RNA, Small Interfering - genetics RNA, Small Interfering - radiation effects Transfection Ultraviolet radiation Ultraviolet Rays 基因表达细胞增生肿瘤细胞食管细胞癌
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