Fluorescence In Situ Hybridization for the Detection of t(X;18)(p11.2;q11.2) in a Synovial Sarcoma Tissue Microarray Using a Breakapart-Style Probe

Synovial sarcomas (SSs) account for 5% of soft tissue tumors and carry a balanced translocation t(X;18)(p11.2;q11.2), detectable in over 90% of cases. This translocation brings together portions of two genesSYT and SSX. Detecting interruption of the SYT gene on chromosome 18 would be useful as a dia...

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Veröffentlicht in:	Diagnostic molecular pathology 2005-06, Vol.14 (2), p.77-82
Hauptverfasser:	Terry, Jefferson, Barry, Todd S, Horsman, Douglas E, Hsu, Forrest D, Gown, Allen M, Huntsman, David G, Nielsen, Torsten O
Format:	Artikel
Sprache:	eng
Schlagworte:	Chromosomes, Human, Pair 11 - genetics Chromosomes, Human, Pair 18 - genetics DNA, Complementary - chemistry Humans In Situ Hybridization, Fluorescence - methods Nucleic Acid Probes Proto-Oncogene Proteins - genetics Repressor Proteins - genetics Sarcoma, Synovial - diagnosis Sarcoma, Synovial - genetics Sequence Deletion Soft Tissue Neoplasms - diagnosis Soft Tissue Neoplasms - genetics Tissue Array Analysis Translocation, Genetic
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