The effect of treatment on health-related quality of life in patients with hypertension and renal artery stenosis

The quality of life in patients with hypertension is considered to be impaired mainly by side effects of antihypertensive drug therapy. Since balloon angioplasty for renal artery stenosis has a medication-sparing effect, it may lead to an improvement in quality of life. The objective of the study is...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Journal of human hypertension 2005-06, Vol.19 (6), p.467-470
Hauptverfasser: Krijnen, P, van Jaarsveld, B C, Hunink, M G M, Habbema, J D F
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 470
container_issue 6
container_start_page 467
container_title Journal of human hypertension
container_volume 19
creator Krijnen, P
van Jaarsveld, B C
Hunink, M G M
Habbema, J D F
description The quality of life in patients with hypertension is considered to be impaired mainly by side effects of antihypertensive drug therapy. Since balloon angioplasty for renal artery stenosis has a medication-sparing effect, it may lead to an improvement in quality of life. The objective of the study is to compare the effect of antihypertensive drug therapy and balloon angioplasty on quality of life in patients with hypertension and renal artery stenosis. We compared the quality of life in 56 patients randomised to balloon angioplasty to that in 50 patients randomised to antihypertensive drug therapy after 3 and 12 months of follow-up. Quality of life was measured using a questionnaire on physical symptoms associated with hypertension and antihypertensive drugs, and two generic health questionnaires (MOS Survey and EuroQol instrument). After follow-up, the patients who underwent angioplasty used less antihypertensive drugs than the patients who were treated with antihypertensive drugs only (mean±s.d., 1.9±0.9 vs 2.5±1.0 drugs after 3 months, P =0.002). They reported similar physical complaints, however, and a similar quality of life. The results after 12 months of follow-up were the same. In conclusion, for patients with hypertension and renal artery stenosis, the decrease in antihypertensive medication after intervention is too small to lead to a detectable improvement in quality of life.
doi_str_mv 10.1038/sj.jhh.1001847
format Article
fullrecord <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_67850254</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A183330784</galeid><sourcerecordid>A183330784</sourcerecordid><originalsourceid>FETCH-LOGICAL-c538t-8f12888ebcfc77ccb2965993a055c0af328951cdbf35cf86cae66333d91a57e93</originalsourceid><addsrcrecordid>eNp1kk1vGyEQhldVq8ZJe-2tFWrU3NaBZWHhGEX9kiL1kp4RZocsFmZtYBX53xfXKzmtEnEAZp53Zhimqj4QvCSYiuu0Xq6HoZwxEW33qlqQtuM1Y033ulpgyXAtmxafVecprQtTnOJtdUZYxyRu6KLa3Q-AwFowGY0W5Qg6byCUS0ADaJ-HOoLXGXq0m7R3eX_AvLOAXEBbnV2BE3p0eUDDfgsxQ0iuiHXoUYSgPdLFFvcoFc-YXHpXvbHaJ3g_7xfV729f729_1He_vv-8vbmrDaMi18KSRggBK2NN1xmzaiRnUlKNGTNYW9oIyYjpV5YyYwU3GjinlPaSaNaBpBfV1THuNo67CVJWG5cMeK8DjFNSvBMMN6wt4OV_4HqcYqk8qYa3mNO2kaxQn1-kiJScN608hXrQHpQLdsxRm0NedUNEqQ534pBw-QxVVg8bZ8YA1hX7P4KrJ4Ljt6TRT7k0Oj0b2cQxpQhWbaPb6LhXBKvDvKi0VmVe1DwvRfBpftW02kB_wucBKcCXGdDJaG-jDsalE8cFJvhv5usjl4orPEA8tefF1B-PiqDzFOFJpUf_H8A94Hw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>219966249</pqid></control><display><type>article</type><title>The effect of treatment on health-related quality of life in patients with hypertension and renal artery stenosis</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>SpringerLink Journals - AutoHoldings</source><creator>Krijnen, P ; van Jaarsveld, B C ; Hunink, M G M ; Habbema, J D F</creator><creatorcontrib>Krijnen, P ; van Jaarsveld, B C ; Hunink, M G M ; Habbema, J D F</creatorcontrib><description>The quality of life in patients with hypertension is considered to be impaired mainly by side effects of antihypertensive drug therapy. Since balloon angioplasty for renal artery stenosis has a medication-sparing effect, it may lead to an improvement in quality of life. The objective of the study is to compare the effect of antihypertensive drug therapy and balloon angioplasty on quality of life in patients with hypertension and renal artery stenosis. We compared the quality of life in 56 patients randomised to balloon angioplasty to that in 50 patients randomised to antihypertensive drug therapy after 3 and 12 months of follow-up. Quality of life was measured using a questionnaire on physical symptoms associated with hypertension and antihypertensive drugs, and two generic health questionnaires (MOS Survey and EuroQol instrument). After follow-up, the patients who underwent angioplasty used less antihypertensive drugs than the patients who were treated with antihypertensive drugs only (mean±s.d., 1.9±0.9 vs 2.5±1.0 drugs after 3 months, P =0.002). They reported similar physical complaints, however, and a similar quality of life. The results after 12 months of follow-up were the same. In conclusion, for patients with hypertension and renal artery stenosis, the decrease in antihypertensive medication after intervention is too small to lead to a detectable improvement in quality of life.</description><identifier>ISSN: 0950-9240</identifier><identifier>EISSN: 1476-5527</identifier><identifier>DOI: 10.1038/sj.jhh.1001847</identifier><identifier>PMID: 15759023</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Aged ; Angioplasty ; Angioplasty, Balloon ; Antihypertensive agents ; Antihypertensive Agents - therapeutic use ; Antihypertensives ; Arterial hypertension. Arterial hypotension ; Biological and medical sciences ; Blood and lymphatic vessels ; Cardiology. Vascular system ; Cardiovascular system ; Care and treatment ; Clinical manifestations. Epidemiology. Investigative techniques. Etiology ; Diuretics ; Drug therapy ; Epidemiology ; Female ; Follow-Up Studies ; Health Administration ; Health aspects ; Humans ; Hypertension ; Hypertension - drug therapy ; Hypertension - etiology ; Hypertension - physiopathology ; Male ; Medical sciences ; Medicine ; Medicine &amp; Public Health ; Middle Aged ; original-article ; Patient outcomes ; Patients ; Pharmacology. Drug treatments ; Public Health ; Quality of Life ; Renal artery ; Renal artery obstruction ; Renal Artery Obstruction - complications ; Renal Artery Obstruction - physiopathology ; Renal Artery Obstruction - therapy ; Stenosis ; Stents ; Surveys and Questionnaires</subject><ispartof>Journal of human hypertension, 2005-06, Vol.19 (6), p.467-470</ispartof><rights>Springer Nature Limited 2005</rights><rights>2005 INIST-CNRS</rights><rights>COPYRIGHT 2005 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Jun 2005</rights><rights>Nature Publishing Group 2005.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c538t-8f12888ebcfc77ccb2965993a055c0af328951cdbf35cf86cae66333d91a57e93</citedby><cites>FETCH-LOGICAL-c538t-8f12888ebcfc77ccb2965993a055c0af328951cdbf35cf86cae66333d91a57e93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/sj.jhh.1001847$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/sj.jhh.1001847$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27922,27923,41486,42555,51317</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&amp;idt=16801084$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15759023$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Krijnen, P</creatorcontrib><creatorcontrib>van Jaarsveld, B C</creatorcontrib><creatorcontrib>Hunink, M G M</creatorcontrib><creatorcontrib>Habbema, J D F</creatorcontrib><title>The effect of treatment on health-related quality of life in patients with hypertension and renal artery stenosis</title><title>Journal of human hypertension</title><addtitle>J Hum Hypertens</addtitle><addtitle>J Hum Hypertens</addtitle><description>The quality of life in patients with hypertension is considered to be impaired mainly by side effects of antihypertensive drug therapy. Since balloon angioplasty for renal artery stenosis has a medication-sparing effect, it may lead to an improvement in quality of life. The objective of the study is to compare the effect of antihypertensive drug therapy and balloon angioplasty on quality of life in patients with hypertension and renal artery stenosis. We compared the quality of life in 56 patients randomised to balloon angioplasty to that in 50 patients randomised to antihypertensive drug therapy after 3 and 12 months of follow-up. Quality of life was measured using a questionnaire on physical symptoms associated with hypertension and antihypertensive drugs, and two generic health questionnaires (MOS Survey and EuroQol instrument). After follow-up, the patients who underwent angioplasty used less antihypertensive drugs than the patients who were treated with antihypertensive drugs only (mean±s.d., 1.9±0.9 vs 2.5±1.0 drugs after 3 months, P =0.002). They reported similar physical complaints, however, and a similar quality of life. The results after 12 months of follow-up were the same. In conclusion, for patients with hypertension and renal artery stenosis, the decrease in antihypertensive medication after intervention is too small to lead to a detectable improvement in quality of life.</description><subject>Aged</subject><subject>Angioplasty</subject><subject>Angioplasty, Balloon</subject><subject>Antihypertensive agents</subject><subject>Antihypertensive Agents - therapeutic use</subject><subject>Antihypertensives</subject><subject>Arterial hypertension. Arterial hypotension</subject><subject>Biological and medical sciences</subject><subject>Blood and lymphatic vessels</subject><subject>Cardiology. Vascular system</subject><subject>Cardiovascular system</subject><subject>Care and treatment</subject><subject>Clinical manifestations. Epidemiology. Investigative techniques. Etiology</subject><subject>Diuretics</subject><subject>Drug therapy</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Health Administration</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Hypertension - drug therapy</subject><subject>Hypertension - etiology</subject><subject>Hypertension - physiopathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Medicine</subject><subject>Medicine &amp; Public Health</subject><subject>Middle Aged</subject><subject>original-article</subject><subject>Patient outcomes</subject><subject>Patients</subject><subject>Pharmacology. Drug treatments</subject><subject>Public Health</subject><subject>Quality of Life</subject><subject>Renal artery</subject><subject>Renal artery obstruction</subject><subject>Renal Artery Obstruction - complications</subject><subject>Renal Artery Obstruction - physiopathology</subject><subject>Renal Artery Obstruction - therapy</subject><subject>Stenosis</subject><subject>Stents</subject><subject>Surveys and Questionnaires</subject><issn>0950-9240</issn><issn>1476-5527</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kk1vGyEQhldVq8ZJe-2tFWrU3NaBZWHhGEX9kiL1kp4RZocsFmZtYBX53xfXKzmtEnEAZp53Zhimqj4QvCSYiuu0Xq6HoZwxEW33qlqQtuM1Y033ulpgyXAtmxafVecprQtTnOJtdUZYxyRu6KLa3Q-AwFowGY0W5Qg6byCUS0ADaJ-HOoLXGXq0m7R3eX_AvLOAXEBbnV2BE3p0eUDDfgsxQ0iuiHXoUYSgPdLFFvcoFc-YXHpXvbHaJ3g_7xfV729f729_1He_vv-8vbmrDaMi18KSRggBK2NN1xmzaiRnUlKNGTNYW9oIyYjpV5YyYwU3GjinlPaSaNaBpBfV1THuNo67CVJWG5cMeK8DjFNSvBMMN6wt4OV_4HqcYqk8qYa3mNO2kaxQn1-kiJScN608hXrQHpQLdsxRm0NedUNEqQ534pBw-QxVVg8bZ8YA1hX7P4KrJ4Ljt6TRT7k0Oj0b2cQxpQhWbaPb6LhXBKvDvKi0VmVe1DwvRfBpftW02kB_wucBKcCXGdDJaG-jDsalE8cFJvhv5usjl4orPEA8tefF1B-PiqDzFOFJpUf_H8A94Hw</recordid><startdate>20050601</startdate><enddate>20050601</enddate><creator>Krijnen, P</creator><creator>van Jaarsveld, B C</creator><creator>Hunink, M G M</creator><creator>Habbema, J D F</creator><general>Nature Publishing Group UK</general><general>Nature Publishing</general><general>Nature Publishing Group</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20050601</creationdate><title>The effect of treatment on health-related quality of life in patients with hypertension and renal artery stenosis</title><author>Krijnen, P ; van Jaarsveld, B C ; Hunink, M G M ; Habbema, J D F</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c538t-8f12888ebcfc77ccb2965993a055c0af328951cdbf35cf86cae66333d91a57e93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Aged</topic><topic>Angioplasty</topic><topic>Angioplasty, Balloon</topic><topic>Antihypertensive agents</topic><topic>Antihypertensive Agents - therapeutic use</topic><topic>Antihypertensives</topic><topic>Arterial hypertension. Arterial hypotension</topic><topic>Biological and medical sciences</topic><topic>Blood and lymphatic vessels</topic><topic>Cardiology. Vascular system</topic><topic>Cardiovascular system</topic><topic>Care and treatment</topic><topic>Clinical manifestations. Epidemiology. Investigative techniques. Etiology</topic><topic>Diuretics</topic><topic>Drug therapy</topic><topic>Epidemiology</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Health Administration</topic><topic>Health aspects</topic><topic>Humans</topic><topic>Hypertension</topic><topic>Hypertension - drug therapy</topic><topic>Hypertension - etiology</topic><topic>Hypertension - physiopathology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Medicine</topic><topic>Medicine &amp; Public Health</topic><topic>Middle Aged</topic><topic>original-article</topic><topic>Patient outcomes</topic><topic>Patients</topic><topic>Pharmacology. Drug treatments</topic><topic>Public Health</topic><topic>Quality of Life</topic><topic>Renal artery</topic><topic>Renal artery obstruction</topic><topic>Renal Artery Obstruction - complications</topic><topic>Renal Artery Obstruction - physiopathology</topic><topic>Renal Artery Obstruction - therapy</topic><topic>Stenosis</topic><topic>Stents</topic><topic>Surveys and Questionnaires</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Krijnen, P</creatorcontrib><creatorcontrib>van Jaarsveld, B C</creatorcontrib><creatorcontrib>Hunink, M G M</creatorcontrib><creatorcontrib>Habbema, J D F</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Health &amp; Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of human hypertension</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Krijnen, P</au><au>van Jaarsveld, B C</au><au>Hunink, M G M</au><au>Habbema, J D F</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effect of treatment on health-related quality of life in patients with hypertension and renal artery stenosis</atitle><jtitle>Journal of human hypertension</jtitle><stitle>J Hum Hypertens</stitle><addtitle>J Hum Hypertens</addtitle><date>2005-06-01</date><risdate>2005</risdate><volume>19</volume><issue>6</issue><spage>467</spage><epage>470</epage><pages>467-470</pages><issn>0950-9240</issn><eissn>1476-5527</eissn><abstract>The quality of life in patients with hypertension is considered to be impaired mainly by side effects of antihypertensive drug therapy. Since balloon angioplasty for renal artery stenosis has a medication-sparing effect, it may lead to an improvement in quality of life. The objective of the study is to compare the effect of antihypertensive drug therapy and balloon angioplasty on quality of life in patients with hypertension and renal artery stenosis. We compared the quality of life in 56 patients randomised to balloon angioplasty to that in 50 patients randomised to antihypertensive drug therapy after 3 and 12 months of follow-up. Quality of life was measured using a questionnaire on physical symptoms associated with hypertension and antihypertensive drugs, and two generic health questionnaires (MOS Survey and EuroQol instrument). After follow-up, the patients who underwent angioplasty used less antihypertensive drugs than the patients who were treated with antihypertensive drugs only (mean±s.d., 1.9±0.9 vs 2.5±1.0 drugs after 3 months, P =0.002). They reported similar physical complaints, however, and a similar quality of life. The results after 12 months of follow-up were the same. In conclusion, for patients with hypertension and renal artery stenosis, the decrease in antihypertensive medication after intervention is too small to lead to a detectable improvement in quality of life.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>15759023</pmid><doi>10.1038/sj.jhh.1001847</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 0950-9240
ispartof Journal of human hypertension, 2005-06, Vol.19 (6), p.467-470
issn 0950-9240
1476-5527
language eng
recordid cdi_proquest_miscellaneous_67850254
source MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; SpringerLink Journals - AutoHoldings
subjects Aged
Angioplasty
Angioplasty, Balloon
Antihypertensive agents
Antihypertensive Agents - therapeutic use
Antihypertensives
Arterial hypertension. Arterial hypotension
Biological and medical sciences
Blood and lymphatic vessels
Cardiology. Vascular system
Cardiovascular system
Care and treatment
Clinical manifestations. Epidemiology. Investigative techniques. Etiology
Diuretics
Drug therapy
Epidemiology
Female
Follow-Up Studies
Health Administration
Health aspects
Humans
Hypertension
Hypertension - drug therapy
Hypertension - etiology
Hypertension - physiopathology
Male
Medical sciences
Medicine
Medicine & Public Health
Middle Aged
original-article
Patient outcomes
Patients
Pharmacology. Drug treatments
Public Health
Quality of Life
Renal artery
Renal artery obstruction
Renal Artery Obstruction - complications
Renal Artery Obstruction - physiopathology
Renal Artery Obstruction - therapy
Stenosis
Stents
Surveys and Questionnaires
title The effect of treatment on health-related quality of life in patients with hypertension and renal artery stenosis
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-10T02%3A13%3A31IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20effect%20of%20treatment%20on%20health-related%20quality%20of%20life%20in%20patients%20with%20hypertension%20and%20renal%20artery%20stenosis&rft.jtitle=Journal%20of%20human%20hypertension&rft.au=Krijnen,%20P&rft.date=2005-06-01&rft.volume=19&rft.issue=6&rft.spage=467&rft.epage=470&rft.pages=467-470&rft.issn=0950-9240&rft.eissn=1476-5527&rft_id=info:doi/10.1038/sj.jhh.1001847&rft_dat=%3Cgale_proqu%3EA183330784%3C/gale_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=219966249&rft_id=info:pmid/15759023&rft_galeid=A183330784&rfr_iscdi=true