Controlled release from fibers of polyelectrolyte complexes

Controlled release systems for delicate compounds, such as proteins, often suffer the drawbacks of decreased bioactivity and low encapsulation efficiency. This study introduces the concept of producing drug-loaded fibers from interfacial polyelectrolyte complexation. Chitosan–alginate fibers were pr...

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Veröffentlicht in:	Journal of controlled release 2005-05, Vol.104 (2), p.347-358
Hauptverfasser:	Liao, I-Chien, Wan, Andrew C.A., Yim, Evelyn K.F., Leong, Kam W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alginate Alginates - administration & dosage Animals Avidin - administration & dosage Avidin - chemistry Biological and medical sciences Chitosan Chitosan - administration & dosage Dexamethasone - administration & dosage Dexamethasone - chemistry Drug Delivery Systems Fibers General pharmacology Glucuronic Acid - administration & dosage Hexuronic Acids - administration & dosage Medical sciences Mice NIH 3T3 Cells Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Platelet-Derived Growth Factor - administration & dosage Platelet-Derived Growth Factor - chemistry Polyelectrolyte complex Proto-Oncogene Proteins c-sis Serum Albumin, Bovine - administration & dosage Serum Albumin, Bovine - chemistry Sustained release of growth factor
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