Regulation of IFN-gamma production by B effector 1 cells: essential roles for T-bet and the IFN-gamma receptor

This manuscript systematically identifies the molecular mechanisms that regulate the ability of B cells to produce the critical type 1 cytokine, IFN-gamma. B cells produce IFN-gamma in response to IL-12 and IL-18 and when primed by Th1 cells. We show that development of IFN-gamma-producing B cells b...

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