Validated HPLC analytical method with programmed wavelength UV detection for simultaneous determination of DRF-4367 and Phenol red in rat in situ intestinal perfusion study

A simple, precise and accurate isocratic reverse-phase liquid chromatography method with programmed wavelength detection has been validated to quantify DRF-4367 and Phenol red, simultaneously for application in rat in situ single pass intestinal perfusion study to assess intestinal permeability of D...

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Veröffentlicht in:	Journal of pharmaceutical and biomedical analysis 2005-06, Vol.38 (1), p.173-179
Hauptverfasser:	Shantha Kumar, T.R., Chawla, Sonia, Nachaegari, Satish K., Singh, Sunil Kumar, Srinivas, Nuggehally R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Analytical, structural and metabolic biochemistry Animals Biological and medical sciences Chromatography, High Pressure Liquid - methods Fundamental and applied biological sciences. Psychology General pharmacology Intestinal permeability Intestines - chemistry Medical sciences Perfusion Pharmacology. Drug treatments Phenolsulfonphthalein - analysis Pyrazoles - analysis Rats Reproducibility of Results Reverse-phase liquid chromatography Spectrophotometry, Ultraviolet - methods Sulfonamides - analysis Validation
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