The multitude of targets for the immune system and drug therapy in the fungal cell wall

Recent studies on fungi revealed that several cytosolic and membrane components migrate to the cell wall together with secreted proteins and biosynthetic polysaccharides to build a dynamic immunoreactive structure. New aspects of fungal cell wall assembly and biosynthesis, focusing on the potential...

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Veröffentlicht in:	Microbes and infection 2005-04, Vol.7 (4), p.789-798
Hauptverfasser:	Nimrichter, Leonardo, Rodrigues, Marcio L., Rodrigues, Elaine G., Travassos, Luiz R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antifungal Agents - pharmacology Antifungal Agents - therapeutic use Antifungal therapy Antimicrobial antibodies Biological and medical sciences Cell Wall - chemistry Cell Wall - drug effects Cell Wall - immunology Fundamental and applied biological sciences. Psychology Fungal cell wall Fungal Proteins - drug effects Fungal Proteins - immunology Fungi - drug effects Fungi - pathogenicity Humans Microbiology Miscellaneous Mycology Mycoses - drug therapy Mycoses - immunology Mycoses - microbiology Unfamiliar components
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Beschreibung
Zusammenfassung:	Recent studies on fungi revealed that several cytosolic and membrane components migrate to the cell wall together with secreted proteins and biosynthetic polysaccharides to build a dynamic immunoreactive structure. New aspects of fungal cell wall assembly and biosynthesis, focusing on the potential of glycolipids, melanin, heat-shock proteins, histone and surface antigens as targets of drugs and antifungal antibodies are discussed.
ISSN:	1286-4579 1769-714X
DOI:	10.1016/j.micinf.2005.03.002