Prevention of abdominal aortic aneurysms by simultaneous inhibition of NFkappaB and ets using chimeric decoy oligonucleotides in a rabbit model

Abdominal aortic aneurysm (AAA) is one of the major vascular diseases caused by atherosclerosis. Because treatment for AAA mainly consists of surgery to prevent deaths from AAA rupture and there is a conspicuous absence of alternative therapeutic strategies, the development of minimally invasive tre...

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Veröffentlicht in:	Gene therapy 2006-04, Vol.13 (8), p.695-704
Hauptverfasser:	Miyake, T, Aoki, M, Nakashima, H, Kawasaki, T, Oishi, M, Kataoka, K, Tanemoto, K, Ogihara, T, Kaneda, Y, Morishita, R
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aorta, Abdominal - diagnostic imaging Aorta, Abdominal - metabolism Aortic Aneurysm, Abdominal - diagnostic imaging Aortic Aneurysm, Abdominal - prevention & control Binding Sites Chemokine CCL2 - metabolism Consensus Sequence Electrophoresis, Polyacrylamide Gel Genetic Therapy - methods Immunohistochemistry - methods Inflammation Macrophages - immunology Male Matrix Metalloproteinase 2 - metabolism Matrix Metalloproteinase 3 - metabolism Microscopy, Fluorescence Models, Animal NF-kappa B - antagonists & inhibitors NF-kappa B - genetics Oligonucleotides - administration & dosage Oligonucleotides - genetics Proto-Oncogene Protein c-ets-1 - antagonists & inhibitors Proto-Oncogene Protein c-ets-1 - genetics Rabbits Radiography Reverse Transcriptase Polymerase Chain Reaction Transfection - methods Ultrasonography Vascular Cell Adhesion Molecule-1 - metabolism
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