Developmental Regulation and In Vitro Culture Effects on Expression of DNA Repair and Cell Cycle Checkpoint Control Genes in Rhesus Monkey Oocytes and Embryos
DNA repair is essential for maintaining genomic integrity, and may be required in the early embryo to correct damage inherited via the gametes, damage that arises during DNA replication, or damage that arises in response to exposure to genotoxic agents. The capacity of preimplantation stage mammalia...
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| Veröffentlicht in: | Biology of reproduction 2005-06, Vol.72 (6), p.1359-1369 |
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| container_title | Biology of reproduction |
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| creator | PING ZHENG SCHRAMM, R. Dee LATHAM, Keith E |
| description | DNA repair is essential for maintaining genomic integrity, and may be required in the early embryo to correct damage inherited
via the gametes, damage that arises during DNA replication, or damage that arises in response to exposure to genotoxic agents.
The capacity of preimplantation stage mammalian embryos to repair damaged DNA has not been well characterized, particularly
in primate embryos. In this study, we examined the expression of 48 mRNAs related to sensing different kinds of DNA damage,
repairing that DNA damage, and controlling the cell cycle to provide an opportunity for DNA repair. The expression data reveal
dynamic temporal changes, indicating a changing ability of the rhesus embryo to detect and repair different kinds of DNA damage.
Low expression or overexpression of specific DNA repair genes may limit the ability of the embryo to respond to DNA damage
at certain stages. Additionally, our data reveal that in vitro culture may lead to dysregulation of many such genes and a
potentially impaired ability to repair DNA damage, thus affecting cellular viability and long-term embryo viability via effects
on genome integrity. This effect of in vitro culture on nonhuman primate embryos may be relevant to assessing the potential
advantages and disadvantages of prolonged in vitro culture of human embryos.
Abstract
Genes related to DNA repair are dynamically regulated in normal rhesus monkey embryos and dysregulated in cultured embryos,
with possible effects on DNA repair capability |
| doi_str_mv | 10.1095/biolreprod.104.039073 |
| format | Article |
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via the gametes, damage that arises during DNA replication, or damage that arises in response to exposure to genotoxic agents.
The capacity of preimplantation stage mammalian embryos to repair damaged DNA has not been well characterized, particularly
in primate embryos. In this study, we examined the expression of 48 mRNAs related to sensing different kinds of DNA damage,
repairing that DNA damage, and controlling the cell cycle to provide an opportunity for DNA repair. The expression data reveal
dynamic temporal changes, indicating a changing ability of the rhesus embryo to detect and repair different kinds of DNA damage.
Low expression or overexpression of specific DNA repair genes may limit the ability of the embryo to respond to DNA damage
at certain stages. Additionally, our data reveal that in vitro culture may lead to dysregulation of many such genes and a
potentially impaired ability to repair DNA damage, thus affecting cellular viability and long-term embryo viability via effects
on genome integrity. This effect of in vitro culture on nonhuman primate embryos may be relevant to assessing the potential
advantages and disadvantages of prolonged in vitro culture of human embryos.
Abstract
Genes related to DNA repair are dynamically regulated in normal rhesus monkey embryos and dysregulated in cultured embryos,
with possible effects on DNA repair capability</description><identifier>ISSN: 0006-3363</identifier><identifier>EISSN: 1529-7268</identifier><identifier>DOI: 10.1095/biolreprod.104.039073</identifier><identifier>PMID: 15703371</identifier><identifier>CODEN: BIREBV</identifier><language>eng</language><publisher>Madison, WI: Society for the Study of Reproduction</publisher><subject>Animals ; Biological and medical sciences ; Cell Cycle - genetics ; Cells, Cultured ; DNA Damage - genetics ; DNA Repair - genetics ; Early stages. Segmentation. Gastrulation. Neurulation ; Embryo Culture Techniques ; Embryology: invertebrates and vertebrates. Teratology ; Embryonic Development - genetics ; Fundamental and applied biological sciences. Psychology ; Gene Expression Regulation, Developmental ; Macaca mulatta ; Oocytes - cytology ; Oocytes - physiology ; Primates ; Vertebrates: reproduction</subject><ispartof>Biology of reproduction, 2005-06, Vol.72 (6), p.1359-1369</ispartof><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16785264$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15703371$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>PING ZHENG</creatorcontrib><creatorcontrib>SCHRAMM, R. Dee</creatorcontrib><creatorcontrib>LATHAM, Keith E</creatorcontrib><title>Developmental Regulation and In Vitro Culture Effects on Expression of DNA Repair and Cell Cycle Checkpoint Control Genes in Rhesus Monkey Oocytes and Embryos</title><title>Biology of reproduction</title><addtitle>Biol Reprod</addtitle><description>DNA repair is essential for maintaining genomic integrity, and may be required in the early embryo to correct damage inherited
via the gametes, damage that arises during DNA replication, or damage that arises in response to exposure to genotoxic agents.
The capacity of preimplantation stage mammalian embryos to repair damaged DNA has not been well characterized, particularly
in primate embryos. In this study, we examined the expression of 48 mRNAs related to sensing different kinds of DNA damage,
repairing that DNA damage, and controlling the cell cycle to provide an opportunity for DNA repair. The expression data reveal
dynamic temporal changes, indicating a changing ability of the rhesus embryo to detect and repair different kinds of DNA damage.
Low expression or overexpression of specific DNA repair genes may limit the ability of the embryo to respond to DNA damage
at certain stages. Additionally, our data reveal that in vitro culture may lead to dysregulation of many such genes and a
potentially impaired ability to repair DNA damage, thus affecting cellular viability and long-term embryo viability via effects
on genome integrity. This effect of in vitro culture on nonhuman primate embryos may be relevant to assessing the potential
advantages and disadvantages of prolonged in vitro culture of human embryos.
Abstract
Genes related to DNA repair are dynamically regulated in normal rhesus monkey embryos and dysregulated in cultured embryos,
with possible effects on DNA repair capability</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cell Cycle - genetics</subject><subject>Cells, Cultured</subject><subject>DNA Damage - genetics</subject><subject>DNA Repair - genetics</subject><subject>Early stages. Segmentation. Gastrulation. Neurulation</subject><subject>Embryo Culture Techniques</subject><subject>Embryology: invertebrates and vertebrates. Teratology</subject><subject>Embryonic Development - genetics</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene Expression Regulation, Developmental</subject><subject>Macaca mulatta</subject><subject>Oocytes - cytology</subject><subject>Oocytes - physiology</subject><subject>Primates</subject><subject>Vertebrates: reproduction</subject><issn>0006-3363</issn><issn>1529-7268</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEFv1DAQhS0EokvhJ4B8obeUsZ3EybFKl1KpUKkCrpGTjLumjh3shCV_ht-KFxb1yGk0mu-9p3mEvGZwzqAu3nXG24BT8EPa83MQNUjxhGxYwetM8rJ6SjYAUGZClOKEvIjxGwDLBRfPyQkrJAgh2Yb8usQfaP00opuVpXd4v1g1G--ocgO9dvSrmYOnzWLnJSDdao39HGm6b39OAWM8oF7Ty08XSTwpE_4IG7SWNmtvkTY77B8mb9xMG--SmaVX6DBS4-jdDuMS6UfvHnClt75f53Q4GGzHLqw-viTPtLIRXx3nKfnyfvu5-ZDd3F5dNxc32U4Am7OqwroCJrUWlayl5nXHAVTeDUPHB65AS11qwXKou0pxlatKwQCsYxKHWoM4JWd_fVOh3xeMczua2KcnlEO_xLaUVZ5XjP0XZDJnBzSBb47g0o04tFMwowpr-6_6BLw9Air2yuqgXG_iI5ciC17mj4k7c7_bm4BtHJW1yVa0-_1e8rZsmShq8RvAzaRG</recordid><startdate>20050601</startdate><enddate>20050601</enddate><creator>PING ZHENG</creator><creator>SCHRAMM, R. Dee</creator><creator>LATHAM, Keith E</creator><general>Society for the Study of Reproduction</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7TM</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20050601</creationdate><title>Developmental Regulation and In Vitro Culture Effects on Expression of DNA Repair and Cell Cycle Checkpoint Control Genes in Rhesus Monkey Oocytes and Embryos</title><author>PING ZHENG ; SCHRAMM, R. Dee ; LATHAM, Keith E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h301t-88e98017ff38797f29b200a4bddb2d2a0f7f6f31409b8a2a4a8a0d01b17ed9f03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Cell Cycle - genetics</topic><topic>Cells, Cultured</topic><topic>DNA Damage - genetics</topic><topic>DNA Repair - genetics</topic><topic>Early stages. Segmentation. Gastrulation. Neurulation</topic><topic>Embryo Culture Techniques</topic><topic>Embryology: invertebrates and vertebrates. Teratology</topic><topic>Embryonic Development - genetics</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gene Expression Regulation, Developmental</topic><topic>Macaca mulatta</topic><topic>Oocytes - cytology</topic><topic>Oocytes - physiology</topic><topic>Primates</topic><topic>Vertebrates: reproduction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>PING ZHENG</creatorcontrib><creatorcontrib>SCHRAMM, R. Dee</creatorcontrib><creatorcontrib>LATHAM, Keith E</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Biology of reproduction</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>PING ZHENG</au><au>SCHRAMM, R. Dee</au><au>LATHAM, Keith E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Developmental Regulation and In Vitro Culture Effects on Expression of DNA Repair and Cell Cycle Checkpoint Control Genes in Rhesus Monkey Oocytes and Embryos</atitle><jtitle>Biology of reproduction</jtitle><addtitle>Biol Reprod</addtitle><date>2005-06-01</date><risdate>2005</risdate><volume>72</volume><issue>6</issue><spage>1359</spage><epage>1369</epage><pages>1359-1369</pages><issn>0006-3363</issn><eissn>1529-7268</eissn><coden>BIREBV</coden><abstract>DNA repair is essential for maintaining genomic integrity, and may be required in the early embryo to correct damage inherited
via the gametes, damage that arises during DNA replication, or damage that arises in response to exposure to genotoxic agents.
The capacity of preimplantation stage mammalian embryos to repair damaged DNA has not been well characterized, particularly
in primate embryos. In this study, we examined the expression of 48 mRNAs related to sensing different kinds of DNA damage,
repairing that DNA damage, and controlling the cell cycle to provide an opportunity for DNA repair. The expression data reveal
dynamic temporal changes, indicating a changing ability of the rhesus embryo to detect and repair different kinds of DNA damage.
Low expression or overexpression of specific DNA repair genes may limit the ability of the embryo to respond to DNA damage
at certain stages. Additionally, our data reveal that in vitro culture may lead to dysregulation of many such genes and a
potentially impaired ability to repair DNA damage, thus affecting cellular viability and long-term embryo viability via effects
on genome integrity. This effect of in vitro culture on nonhuman primate embryos may be relevant to assessing the potential
advantages and disadvantages of prolonged in vitro culture of human embryos.
Abstract
Genes related to DNA repair are dynamically regulated in normal rhesus monkey embryos and dysregulated in cultured embryos,
with possible effects on DNA repair capability</abstract><cop>Madison, WI</cop><pub>Society for the Study of Reproduction</pub><pmid>15703371</pmid><doi>10.1095/biolreprod.104.039073</doi><tpages>11</tpages></addata></record> |
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| issn | 0006-3363 1529-7268 |
| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; BioOne Complete; Oxford University Press Journals All Titles (1996-Current) |
| subjects | Animals Biological and medical sciences Cell Cycle - genetics Cells, Cultured DNA Damage - genetics DNA Repair - genetics Early stages. Segmentation. Gastrulation. Neurulation Embryo Culture Techniques Embryology: invertebrates and vertebrates. Teratology Embryonic Development - genetics Fundamental and applied biological sciences. Psychology Gene Expression Regulation, Developmental Macaca mulatta Oocytes - cytology Oocytes - physiology Primates Vertebrates: reproduction |
| title | Developmental Regulation and In Vitro Culture Effects on Expression of DNA Repair and Cell Cycle Checkpoint Control Genes in Rhesus Monkey Oocytes and Embryos |
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