Unexpected Ring-Opening Reactions of Aziridines with Aldehydes Catalyzed by Nucleophilic Carbenes under Aerobic Conditions
The chemoselective ring opening of N-tosyl aziridines with aldehydes catalyzed by an N-heterocyclic carbene was investigated under aerobic conditions. Unexpected carboxylates of 1,2-amino alcohols from the corresponding aldehydes, rather than the acyl anion ring-opened β-amino ketones, were exclusiv...
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Veröffentlicht in: | Organic letters 2006-04, Vol.8 (8), p.1521-1524 |
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Sprache: | eng |
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