Development of Polymer Latex Particles for Selective Cleavage of Mismatched DNA and Their Application for DNA Diagnosis

We developed functional polymer latex particles that can catch and cleave mismatched DNA selectively and propose a new mismatch detection system using the functional particles. The aimed particles possess two functional units composed of mismatch binding protein (MutS) and an anthraquinone derivativ...

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Veröffentlicht in:	Bioconjugate chemistry 2005-05, Vol.16 (3), p.551-558
Hauptverfasser:	Oba, Shinsuke, Hatakeyama, Mamoru, Handa, Hiroshi, Kawaguchi, Haruma
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphatases - metabolism Bacterial Proteins - metabolism Base Pair Mismatch - genetics Base Sequence Chemistry Deoxyribonucleic acid DNA DNA - genetics DNA - metabolism DNA-Binding Proteins - metabolism Enzymes, Immobilized - metabolism Genetic Testing - methods Latex - chemistry Microscopy, Electron, Transmission Microspheres MutS DNA Mismatch-Binding Protein Particle Size Photolysis Polymers Spectrometry, Fluorescence Tosyl Compounds - chemistry
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