Excitability of motor cortex inhibitory circuits in Tourette syndrome before and after single dose nicotine

The pathophysiology underlying the involuntary tics of Gilles de la Tourette syndrome (GTS) remains unknown. Here we used transcranial magnetic stimulation (TMS) to examine the excitability of two different inhibitory systems in the human motor cortex: short interval intracortical inhibition (SICI)...

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Veröffentlicht in:	Brain (London, England : 1878) England : 1878), 2005-06, Vol.128 (6), p.1292-1300
Hauptverfasser:	Orth, M., Amann, B., Robertson, M. M., Rothwell, J. C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult AMT = active motor threshold Biological and medical sciences CSI = conditioning stimulus intensity CSP = cortical silent period Electromyography Evoked Potentials, Motor - drug effects FDI = first dorsal interosseus muscle Female GCI = global clinical impression Gilles de la Tourette syndrome GTS = Gilles de la Tourette syndrome Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy Humans ICF = intracortical facilitation intracortical inhibition ISI = interstimulus interval Magnetics Male Malformations of the nervous system Medical sciences MEP = motor evoked potential Middle Aged Motor Cortex - drug effects Motor Cortex - physiopathology MRVS = modified Rush Video Scale Nervous system (semeiology, syndromes) Neural Inhibition - drug effects Neurology Neurons, Afferent Nicotine - pharmacology Nicotine - therapeutic use Nicotinic Agonists - pharmacology Nicotinic Agonists - therapeutic use SAI = short interval afferent inhibition sensory afferent inhibition Severity of Illness Index SICI = short interval intracortical inhibition tic treatment Tics - drug therapy Tics - physiopathology TMS = transcranial magnetic stimulation Tourette Syndrome - drug therapy Tourette Syndrome - physiopathology transcranial magnetic stimulation
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