Inhibitors of the epidermal growth factor receptor in apple juice extract

The polyphenol‐rich extract of a consumer‐relevant apple juice blend was found to potently inhibit the growth of the human colon cancer cell line HT29 in vitro. The epidermal growth factor receptor (EGFR) and its subsequent signaling cascade play an important role in the regulation of cell prolifera...

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Veröffentlicht in:	Molecular nutrition & food research 2005-04, Vol.49 (4), p.317-328
Hauptverfasser:	Kern, Melanie, Tjaden, Zeina, Ngiewih, Yufanyi, Puppel, Nicole, Will, Frank, Dietrich, Helmut, Pahlke, Gudrun, Marko, Doris
Format:	Artikel
Sprache:	eng
Schlagworte:	Apple polyphenols Beverages - analysis Biological and medical sciences Caffeic Acids - pharmacology Cell Division - drug effects Colon carcinoma Colonic Neoplasms - pathology DNA-Binding Proteins - genetics Enzyme Inhibitors - pharmacology Epidermal growth factor receptor ets-Domain Protein Elk-1 Female Flavonoids - analysis Flavonoids - pharmacology Food industries Fruit and vegetable industries Fundamental and applied biological sciences. Psychology Gene Expression Growth inhibition Humans Luciferases - genetics Malus - chemistry Mitogen-activated protein kinase Mitogen-Activated Protein Kinases - antagonists & inhibitors Phenols - analysis Phenols - pharmacology Plant Extracts - chemistry Plant Extracts - pharmacology Polyphenols Proto-Oncogene Proteins - genetics Receptor, Epidermal Growth Factor - antagonists & inhibitors Recombinant Fusion Proteins Saccharomyces cerevisiae Proteins - genetics Transcription Factors - genetics Transfection Tumor Cells, Cultured Vulvar Neoplasms
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