Structural Studies of the Parainfluenza Virus 5 Hemagglutinin-Neuraminidase Tetramer in Complex with Its Receptor, Sialyllactose

The paramyxovirus hemagglutinin-neuraminidase (HN) functions in virus attachment to cells, cleavage of sialic acid from oligosaccharides, and stimulating membrane fusion during virus entry into cells. The structural basis for these diverse functions remains to be fully understood. We report the crys...

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Veröffentlicht in:	Structure (London) 2005-05, Vol.13 (5), p.803-815
Hauptverfasser:	Yuan, Ping, Thompson, Thomas B., Wurzburg, Beth A., Paterson, Reay G., Lamb, Robert A., Jardetzky, Theodore S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Binding Sites Dimerization HN Protein - chemistry Lactose - analogs & derivatives Lactose - chemistry Ligands Molecular Sequence Data N-Acetylneuraminic Acid - chemistry Protein Conformation Receptors, Virus - chemistry Respirovirus - metabolism
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