Enantioselective Total Synthesis of Litseaverticillols A and B
The first enantioselective total synthesis of the (1R,5S)-stereoisomer of litseaverticillols A and B, anti-HIV monocyclic sesquiterpenoids isolated from a perennial shrub found in Vietnam, was accomplished in six steps from homogeranic acid by employing the Evans asymmetric aldol reaction and a micr...
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| Veröffentlicht in: | Organic letters 2006-04, Vol.8 (8), p.1613-1616 |
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| container_title | Organic letters |
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| creator | Morita, Akira Kuwahara, Shigefumi |
| description | The first enantioselective total synthesis of the (1R,5S)-stereoisomer of litseaverticillols A and B, anti-HIV monocyclic sesquiterpenoids isolated from a perennial shrub found in Vietnam, was accomplished in six steps from homogeranic acid by employing the Evans asymmetric aldol reaction and a microwave-promoted cyclization of a stannylated thiol ester intermediate as the C−C bond-forming steps. |
| doi_str_mv | 10.1021/ol053122a |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 1523-7060 |
| ispartof | Organic letters, 2006-04, Vol.8 (8), p.1613-1616 |
| issn | 1523-7060 1523-7052 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_67837636 |
| source | MEDLINE; American Chemical Society Journals |
| subjects | Anti-HIV Agents - chemical synthesis Anti-HIV Agents - chemistry Anti-HIV Agents - pharmacology Catalysis Cyclization Molecular Structure Sesquiterpenes - chemical synthesis Sesquiterpenes - chemistry Sesquiterpenes - pharmacology Stereoisomerism |
| title | Enantioselective Total Synthesis of Litseaverticillols A and B |
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