Recombinant canarypox vectored West Nile virus (WNV) vaccine protects dogs and cats against a mosquito WNV challenge
The safety and efficacy of a canarypox vector expressing PrM and E genes of West Nile virus (WNV) (ALVAC-WNV) was evaluated in dogs and cats. One group of 17 dogs (vaccinated with 10 5.6 TCID 50) and two groups of cats (groups 1 [ n = 14] vaccinated with 10 7.5 TCID 50 and 2 [ n = 8] 10 5.6 TCID 50)...
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| Veröffentlicht in: | Vaccine 2005-05, Vol.23 (29), p.3808-3813 |
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| creator | Karaca, K. Bowen, R. Austgen, L.E. Teehee, M. Siger, L. Grosenbaugh, D. Loosemore, L. Audonnet, J.-C. Nordgren, R. Minke, J.M. |
| description | The safety and efficacy of a canarypox vector expressing PrM and E genes of West Nile virus (WNV) (ALVAC-WNV) was evaluated in dogs and cats. One group of 17 dogs (vaccinated with 10
5.6 TCID
50) and two groups of cats (groups 1 [
n
=
14] vaccinated with 10
7.5 TCID
50 and 2 [
n
=
8] 10
5.6 TCID
50) were vaccinated twice at 28-day intervals. Fifteen dogs and eleven cats served as negative controls. The cats and dogs were challenged 120 and 135
days after the second immunization, respectively via the bites of
Aedes albopictus mosquitoes infected with WNV. The first dose of vaccine induced a detectable antibody response in four dogs and five cats (one immunized with low and four with high doses). After the second dose, all the vaccinated dogs and all of the cats, immunized with high dose had detectable antibody titers, whereas only four of eight cats in the low dose group were seropositive. None of the vaccinated dogs and one vaccinated cat developed viremia following the WNV mosquito-challenge. In contrast, 14 of the 15 control dogs and 9 of the 11 control cats developed viremia. The experimental vaccine described in this study may be of value in the prevention of WNV infection in dogs and cats. |
| doi_str_mv | 10.1016/j.vaccine.2005.02.020 |
| format | Article |
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5.6 TCID
50) and two groups of cats (groups 1 [
n
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14] vaccinated with 10
7.5 TCID
50 and 2 [
n
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days after the second immunization, respectively via the bites of
Aedes albopictus mosquitoes infected with WNV. The first dose of vaccine induced a detectable antibody response in four dogs and five cats (one immunized with low and four with high doses). After the second dose, all the vaccinated dogs and all of the cats, immunized with high dose had detectable antibody titers, whereas only four of eight cats in the low dose group were seropositive. None of the vaccinated dogs and one vaccinated cat developed viremia following the WNV mosquito-challenge. In contrast, 14 of the 15 control dogs and 9 of the 11 control cats developed viremia. The experimental vaccine described in this study may be of value in the prevention of WNV infection in dogs and cats.</description><identifier>ISSN: 0264-410X</identifier><identifier>EISSN: 1873-2518</identifier><identifier>DOI: 10.1016/j.vaccine.2005.02.020</identifier><identifier>PMID: 15893618</identifier><identifier>CODEN: VACCDE</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Aedes albopictus ; Animals ; Antibodies, Viral - blood ; Applied microbiology ; Aquatic insects ; Biological and medical sciences ; Canarypox vectored West Nile vaccine ; Canarypox virus ; Canarypox virus - genetics ; Cat Diseases - prevention & control ; Cats ; Dog Diseases - prevention & control ; Dogs ; Fundamental and applied biological sciences. Psychology ; Horses ; Immunization ; Infections ; Microbiology ; Miscellaneous ; Mosquito ; Mosquitoes ; Vaccines ; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) ; Vaccines, Synthetic - genetics ; Vaccines, Synthetic - immunology ; Vaccines, Synthetic - virology ; Vector-borne diseases ; Viral Envelope Proteins - genetics ; Viral Envelope Proteins - immunology ; Viral infections ; Viral Vaccines - adverse effects ; Viral Vaccines - genetics ; Viral Vaccines - immunology ; Virology ; West Nile Fever - prevention & control ; West Nile Fever - veterinary ; West Nile virus ; West Nile virus - genetics ; West Nile virus - immunology</subject><ispartof>Vaccine, 2005-05, Vol.23 (29), p.3808-3813</ispartof><rights>2005 Elsevier Ltd</rights><rights>2005 INIST-CNRS</rights><rights>Copyright Elsevier Limited May 31, 2005</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c452t-f17701e12a5c07c9df0d14faf8865ebd18616a6771b3d8d71d51eb752cc6169b3</citedby><cites>FETCH-LOGICAL-c452t-f17701e12a5c07c9df0d14faf8865ebd18616a6771b3d8d71d51eb752cc6169b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/1547036411?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995,64385,64387,64389,72469</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16801383$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15893618$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Karaca, K.</creatorcontrib><creatorcontrib>Bowen, R.</creatorcontrib><creatorcontrib>Austgen, L.E.</creatorcontrib><creatorcontrib>Teehee, M.</creatorcontrib><creatorcontrib>Siger, L.</creatorcontrib><creatorcontrib>Grosenbaugh, D.</creatorcontrib><creatorcontrib>Loosemore, L.</creatorcontrib><creatorcontrib>Audonnet, J.-C.</creatorcontrib><creatorcontrib>Nordgren, R.</creatorcontrib><creatorcontrib>Minke, J.M.</creatorcontrib><title>Recombinant canarypox vectored West Nile virus (WNV) vaccine protects dogs and cats against a mosquito WNV challenge</title><title>Vaccine</title><addtitle>Vaccine</addtitle><description>The safety and efficacy of a canarypox vector expressing PrM and E genes of West Nile virus (WNV) (ALVAC-WNV) was evaluated in dogs and cats. One group of 17 dogs (vaccinated with 10
5.6 TCID
50) and two groups of cats (groups 1 [
n
=
14] vaccinated with 10
7.5 TCID
50 and 2 [
n
=
8] 10
5.6 TCID
50) were vaccinated twice at 28-day intervals. Fifteen dogs and eleven cats served as negative controls. The cats and dogs were challenged 120 and 135
days after the second immunization, respectively via the bites of
Aedes albopictus mosquitoes infected with WNV. The first dose of vaccine induced a detectable antibody response in four dogs and five cats (one immunized with low and four with high doses). After the second dose, all the vaccinated dogs and all of the cats, immunized with high dose had detectable antibody titers, whereas only four of eight cats in the low dose group were seropositive. None of the vaccinated dogs and one vaccinated cat developed viremia following the WNV mosquito-challenge. In contrast, 14 of the 15 control dogs and 9 of the 11 control cats developed viremia. The experimental vaccine described in this study may be of value in the prevention of WNV infection in dogs and cats.</description><subject>Aedes albopictus</subject><subject>Animals</subject><subject>Antibodies, Viral - blood</subject><subject>Applied microbiology</subject><subject>Aquatic insects</subject><subject>Biological and medical sciences</subject><subject>Canarypox vectored West Nile vaccine</subject><subject>Canarypox virus</subject><subject>Canarypox virus - genetics</subject><subject>Cat Diseases - prevention & control</subject><subject>Cats</subject><subject>Dog Diseases - prevention & control</subject><subject>Dogs</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Horses</subject><subject>Immunization</subject><subject>Infections</subject><subject>Microbiology</subject><subject>Miscellaneous</subject><subject>Mosquito</subject><subject>Mosquitoes</subject><subject>Vaccines</subject><subject>Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)</subject><subject>Vaccines, Synthetic - genetics</subject><subject>Vaccines, Synthetic - immunology</subject><subject>Vaccines, Synthetic - virology</subject><subject>Vector-borne diseases</subject><subject>Viral Envelope Proteins - genetics</subject><subject>Viral Envelope Proteins - immunology</subject><subject>Viral infections</subject><subject>Viral Vaccines - adverse effects</subject><subject>Viral Vaccines - genetics</subject><subject>Viral Vaccines - immunology</subject><subject>Virology</subject><subject>West Nile Fever - prevention & control</subject><subject>West Nile Fever - veterinary</subject><subject>West Nile virus</subject><subject>West Nile virus - genetics</subject><subject>West Nile virus - immunology</subject><issn>0264-410X</issn><issn>1873-2518</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFkV9rFDEUxYModq1-BCUgij7MmptM_uxTkdKqUCqIWt9CJsmsWWaSbTKz6Lc3ZQcKvhQuhJDfubn3HIReAlkDAfFhtz4Ya0P0a0oIXxNaizxCK1CSNZSDeoxWhIq2aYH8OkHPStmRCjLYPEUnwNWGCVArNH3zNo1diCZO2Jpo8t99-oMP3k4pe4dvfJnwdRg8PoQ8F_zu5vrne7x8jfc5TZUs2KVtwSa62qLezNaEWHUGj6nczmFKuMqw_W2Gwcetf46e9GYo_sVynqIflxffzz83V18_fTn_eNXYltOp6UFKAh6o4ZZIu3E9cdD2pldKcN85UAKEEVJCx5xyEhwH30lOra0Pm46dorfHvnXO27luosdQrB8GE32aixZSMQmMPgiCpExwoir4-j9wl-Yc6xIaeCsJEy1ApfiRsjmVkn2v9zmM1VoNRN-lp3d6sVDfpacJrUWq7tXSfe5G7-5VS1wVeLMAplgz9NlEG8o9JxQBpljlzo6cr-4egs-62OCj9S7kmpd2KTwwyj9oxLpU</recordid><startdate>20050531</startdate><enddate>20050531</enddate><creator>Karaca, K.</creator><creator>Bowen, R.</creator><creator>Austgen, L.E.</creator><creator>Teehee, M.</creator><creator>Siger, L.</creator><creator>Grosenbaugh, D.</creator><creator>Loosemore, L.</creator><creator>Audonnet, J.-C.</creator><creator>Nordgren, R.</creator><creator>Minke, J.M.</creator><general>Elsevier Ltd</general><general>Elsevier</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7RV</scope><scope>7T2</scope><scope>7T5</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88C</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0R</scope><scope>M0S</scope><scope>M0T</scope><scope>M1P</scope><scope>M2O</scope><scope>M7N</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20050531</creationdate><title>Recombinant canarypox vectored West Nile virus (WNV) vaccine protects dogs and cats against a mosquito WNV challenge</title><author>Karaca, K. ; Bowen, R. ; Austgen, L.E. ; Teehee, M. ; Siger, L. ; Grosenbaugh, D. ; Loosemore, L. ; Audonnet, J.-C. ; Nordgren, R. ; Minke, J.M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c452t-f17701e12a5c07c9df0d14faf8865ebd18616a6771b3d8d71d51eb752cc6169b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Aedes albopictus</topic><topic>Animals</topic><topic>Antibodies, Viral - blood</topic><topic>Applied microbiology</topic><topic>Aquatic insects</topic><topic>Biological and medical sciences</topic><topic>Canarypox vectored West Nile vaccine</topic><topic>Canarypox virus</topic><topic>Canarypox virus - genetics</topic><topic>Cat Diseases - prevention & control</topic><topic>Cats</topic><topic>Dog Diseases - prevention & control</topic><topic>Dogs</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Horses</topic><topic>Immunization</topic><topic>Infections</topic><topic>Microbiology</topic><topic>Miscellaneous</topic><topic>Mosquito</topic><topic>Mosquitoes</topic><topic>Vaccines</topic><topic>Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)</topic><topic>Vaccines, Synthetic - genetics</topic><topic>Vaccines, Synthetic - immunology</topic><topic>Vaccines, Synthetic - virology</topic><topic>Vector-borne diseases</topic><topic>Viral Envelope Proteins - genetics</topic><topic>Viral Envelope Proteins - immunology</topic><topic>Viral infections</topic><topic>Viral Vaccines - adverse effects</topic><topic>Viral Vaccines - genetics</topic><topic>Viral Vaccines - immunology</topic><topic>Virology</topic><topic>West Nile Fever - prevention & control</topic><topic>West Nile Fever - veterinary</topic><topic>West Nile virus</topic><topic>West Nile virus - genetics</topic><topic>West Nile virus - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Karaca, K.</creatorcontrib><creatorcontrib>Bowen, R.</creatorcontrib><creatorcontrib>Austgen, L.E.</creatorcontrib><creatorcontrib>Teehee, M.</creatorcontrib><creatorcontrib>Siger, L.</creatorcontrib><creatorcontrib>Grosenbaugh, D.</creatorcontrib><creatorcontrib>Loosemore, L.</creatorcontrib><creatorcontrib>Audonnet, J.-C.</creatorcontrib><creatorcontrib>Nordgren, R.</creatorcontrib><creatorcontrib>Minke, J.M.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Nursing & Allied Health Database</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Healthcare Administration Database (Alumni)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Healthcare Administration Database</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Vaccine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Karaca, K.</au><au>Bowen, R.</au><au>Austgen, L.E.</au><au>Teehee, M.</au><au>Siger, L.</au><au>Grosenbaugh, D.</au><au>Loosemore, L.</au><au>Audonnet, J.-C.</au><au>Nordgren, R.</au><au>Minke, J.M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Recombinant canarypox vectored West Nile virus (WNV) vaccine protects dogs and cats against a mosquito WNV challenge</atitle><jtitle>Vaccine</jtitle><addtitle>Vaccine</addtitle><date>2005-05-31</date><risdate>2005</risdate><volume>23</volume><issue>29</issue><spage>3808</spage><epage>3813</epage><pages>3808-3813</pages><issn>0264-410X</issn><eissn>1873-2518</eissn><coden>VACCDE</coden><abstract>The safety and efficacy of a canarypox vector expressing PrM and E genes of West Nile virus (WNV) (ALVAC-WNV) was evaluated in dogs and cats. One group of 17 dogs (vaccinated with 10
5.6 TCID
50) and two groups of cats (groups 1 [
n
=
14] vaccinated with 10
7.5 TCID
50 and 2 [
n
=
8] 10
5.6 TCID
50) were vaccinated twice at 28-day intervals. Fifteen dogs and eleven cats served as negative controls. The cats and dogs were challenged 120 and 135
days after the second immunization, respectively via the bites of
Aedes albopictus mosquitoes infected with WNV. The first dose of vaccine induced a detectable antibody response in four dogs and five cats (one immunized with low and four with high doses). After the second dose, all the vaccinated dogs and all of the cats, immunized with high dose had detectable antibody titers, whereas only four of eight cats in the low dose group were seropositive. None of the vaccinated dogs and one vaccinated cat developed viremia following the WNV mosquito-challenge. In contrast, 14 of the 15 control dogs and 9 of the 11 control cats developed viremia. The experimental vaccine described in this study may be of value in the prevention of WNV infection in dogs and cats.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>15893618</pmid><doi>10.1016/j.vaccine.2005.02.020</doi><tpages>6</tpages></addata></record> |
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| ispartof | Vaccine, 2005-05, Vol.23 (29), p.3808-3813 |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete; ProQuest Central UK/Ireland |
| subjects | Aedes albopictus Animals Antibodies, Viral - blood Applied microbiology Aquatic insects Biological and medical sciences Canarypox vectored West Nile vaccine Canarypox virus Canarypox virus - genetics Cat Diseases - prevention & control Cats Dog Diseases - prevention & control Dogs Fundamental and applied biological sciences. Psychology Horses Immunization Infections Microbiology Miscellaneous Mosquito Mosquitoes Vaccines Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) Vaccines, Synthetic - genetics Vaccines, Synthetic - immunology Vaccines, Synthetic - virology Vector-borne diseases Viral Envelope Proteins - genetics Viral Envelope Proteins - immunology Viral infections Viral Vaccines - adverse effects Viral Vaccines - genetics Viral Vaccines - immunology Virology West Nile Fever - prevention & control West Nile Fever - veterinary West Nile virus West Nile virus - genetics West Nile virus - immunology |
| title | Recombinant canarypox vectored West Nile virus (WNV) vaccine protects dogs and cats against a mosquito WNV challenge |
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