TREX, SR proteins and export of mRNA
The machineries involved in gene expression are highly conserved from yeast to metazoans. However, a fundamental difference between these organisms is that most yeast genes lack introns whereas the converse is true in higher organisms. Recent studies of the TREX complex, which functions in mRNA expo...
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| Veröffentlicht in: | Current opinion in cell biology 2005-06, Vol.17 (3), p.269-273 |
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| container_title | Current opinion in cell biology |
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| creator | Reed, Robin Cheng, Hong |
| description | The machineries involved in gene expression are highly conserved from yeast to metazoans. However, a fundamental difference between these organisms is that most yeast genes lack introns whereas the converse is true in higher organisms. Recent studies of the TREX complex, which functions in mRNA export, unexpectedly revealed that this complex is recruited by the transcription machinery in yeast whereas the TREX complex appears to be recruited by the splicing machinery in mammals. Studies during the past year also revealed a possible conserved role for SR protein dephosphorylation in regulating the interaction between SR proteins and the mRNA export receptor TAP (Mex67 in yeast). There is also an interesting possibility that an SR protein–TREX complex interaction is a conserved part of the mRNA export machinery. |
| doi_str_mv | 10.1016/j.ceb.2005.04.011 |
| format | Article |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Active Transport, Cell Nucleus - physiology Animals Cell Nucleus - metabolism Humans Introns - genetics Metazoa Models, Biological Multiprotein Complexes - physiology Nuclear Proteins - physiology Phosphoproteins RNA Splicing - physiology RNA Transport - physiology RNA, Messenger - metabolism RNA-Binding Proteins - physiology Serine-Arginine Splicing Factors Yeasts - genetics Yeasts - metabolism |
| title | TREX, SR proteins and export of mRNA |
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