New Antibiotic Sch 725424 and Its Dehydration Product Sch 725428 from Kitasatospora sp
A new microbial metabolite Sch 725424 ( 1 ) was isolated from the culture of Kitasatospora sp. The structure elucidation of 1 was accomplished based on NMR spectroscopic analyses as well as extensive structure elucidation of its dehydration product Sch 725428 ( 2 ). Compound 1 showed inhibitory acti...
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| Veröffentlicht in: | Journal of antibiotics 2005-03, Vol.58 (3), p.192-195 |
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| container_issue | 3 |
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| container_title | Journal of antibiotics |
| container_volume | 58 |
| creator | Yang, Shu-Wei Chan, Tze-Ming Terracciano, Joseph Patel, Reena Loebenberg, David Chen, Guodong Patel, Mahesh Gullo, Vincent Pramanik, Birendra Chu, Min |
| description | A new microbial metabolite Sch 725424 (
1
) was isolated from the culture of
Kitasatospora
sp. The structure elucidation of
1
was accomplished based on NMR spectroscopic analyses as well as extensive structure elucidation of its dehydration product Sch 725428 (
2
). Compound
1
showed inhibitory activity against
Staphylococcus aureus
with MIC values 1∼2 µg/ml, and also displayed weak antifungal activity against
Saccharomyces cerevisiae
(PM503) with an MIC 32 µg/ml. |
| doi_str_mv | 10.1038/ja.2005.22 |
| format | Article |
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1
) was isolated from the culture of
Kitasatospora
sp. The structure elucidation of
1
was accomplished based on NMR spectroscopic analyses as well as extensive structure elucidation of its dehydration product Sch 725428 (
2
). Compound
1
showed inhibitory activity against
Staphylococcus aureus
with MIC values 1∼2 µg/ml, and also displayed weak antifungal activity against
Saccharomyces cerevisiae
(PM503) with an MIC 32 µg/ml.</description><identifier>ISSN: 0021-8820</identifier><identifier>EISSN: 1881-1469</identifier><identifier>DOI: 10.1038/ja.2005.22</identifier><identifier>PMID: 15895527</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Amides - chemistry ; Amides - metabolism ; Amides - pharmacology ; Anti-Bacterial Agents - biosynthesis ; Anti-Bacterial Agents - chemistry ; Anti-Bacterial Agents - pharmacology ; Antifungal Agents - chemistry ; Antifungal Agents - metabolism ; Antifungal Agents - pharmacology ; Bacteriology ; Biomedical and Life Sciences ; Bioorganic Chemistry ; Dehydration ; Fermentation ; Furans - chemistry ; Furans - metabolism ; Furans - pharmacology ; Kitasatospora ; Life Sciences ; Magnetic Resonance Spectroscopy ; Medicinal Chemistry ; Metabolites ; Microbial Sensitivity Tests ; Microbiology ; Molecular Structure ; Organic Chemistry ; Polyenes - chemistry ; Polyenes - metabolism ; Polyenes - pharmacology ; Saccharomyces cerevisiae ; Saccharomyces cerevisiae - drug effects ; Staphylococcus aureus ; Staphylococcus aureus - drug effects ; Streptomycetaceae - metabolism</subject><ispartof>Journal of antibiotics, 2005-03, Vol.58 (3), p.192-195</ispartof><rights>Japan Antibiotics Research Association 2005</rights><rights>Copyright Nature Publishing Group Mar 2005</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c445t-cfe56291d06dceab3a813dacfa3d35b6af255c33818ba5c0356f5f124eebd40e3</citedby><cites>FETCH-LOGICAL-c445t-cfe56291d06dceab3a813dacfa3d35b6af255c33818ba5c0356f5f124eebd40e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15895527$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yang, Shu-Wei</creatorcontrib><creatorcontrib>Chan, Tze-Ming</creatorcontrib><creatorcontrib>Terracciano, Joseph</creatorcontrib><creatorcontrib>Patel, Reena</creatorcontrib><creatorcontrib>Loebenberg, David</creatorcontrib><creatorcontrib>Chen, Guodong</creatorcontrib><creatorcontrib>Patel, Mahesh</creatorcontrib><creatorcontrib>Gullo, Vincent</creatorcontrib><creatorcontrib>Pramanik, Birendra</creatorcontrib><creatorcontrib>Chu, Min</creatorcontrib><title>New Antibiotic Sch 725424 and Its Dehydration Product Sch 725428 from Kitasatospora sp</title><title>Journal of antibiotics</title><addtitle>J Antibiot</addtitle><addtitle>J Antibiot (Tokyo)</addtitle><description>A new microbial metabolite Sch 725424 (
1
) was isolated from the culture of
Kitasatospora
sp. The structure elucidation of
1
was accomplished based on NMR spectroscopic analyses as well as extensive structure elucidation of its dehydration product Sch 725428 (
2
). Compound
1
showed inhibitory activity against
Staphylococcus aureus
with MIC values 1∼2 µg/ml, and also displayed weak antifungal activity against
Saccharomyces cerevisiae
(PM503) with an MIC 32 µg/ml.</description><subject>Amides - chemistry</subject><subject>Amides - metabolism</subject><subject>Amides - pharmacology</subject><subject>Anti-Bacterial Agents - biosynthesis</subject><subject>Anti-Bacterial Agents - chemistry</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Antifungal Agents - chemistry</subject><subject>Antifungal Agents - metabolism</subject><subject>Antifungal Agents - pharmacology</subject><subject>Bacteriology</subject><subject>Biomedical and Life Sciences</subject><subject>Bioorganic Chemistry</subject><subject>Dehydration</subject><subject>Fermentation</subject><subject>Furans - chemistry</subject><subject>Furans - metabolism</subject><subject>Furans - pharmacology</subject><subject>Kitasatospora</subject><subject>Life Sciences</subject><subject>Magnetic Resonance Spectroscopy</subject><subject>Medicinal Chemistry</subject><subject>Metabolites</subject><subject>Microbial Sensitivity Tests</subject><subject>Microbiology</subject><subject>Molecular Structure</subject><subject>Organic Chemistry</subject><subject>Polyenes - chemistry</subject><subject>Polyenes - metabolism</subject><subject>Polyenes - pharmacology</subject><subject>Saccharomyces cerevisiae</subject><subject>Saccharomyces cerevisiae - drug effects</subject><subject>Staphylococcus aureus</subject><subject>Staphylococcus aureus - drug effects</subject><subject>Streptomycetaceae - metabolism</subject><issn>0021-8820</issn><issn>1881-1469</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqF0ctKAzEUBuAgiq3VjQ8gAcGFMjWXyaXLUm_FooKX7ZBJMjpDOxmTDNK3d0oLFV24Oovz8R8OPwDHGA0xovKyUkOCEBsSsgP6WEqc4JSPdkEfIYITKQnqgYMQKoSooELugx5mcsQYEX3w9mC_4LiOZV66WGr4rD-gICwlKVS1gdMY4JX9WBqvYulq-OSdaXXcMgkL7xbwvowqqOhC47yCoTkEe4WaB3u0mQPwenP9MrlLZo-308l4lug0ZTHRhWWcjLBB3GircqokpkbpQlFDWc5VQRjTlEosc8U0oowXrMAktTY3KbJ0AM7WuY13n60NMVuUQdv5XNXWtSHjQlIuuPgXYsEQGnHUwdNfsHKtr7snOiOFJETytFPna6W9C8HbImt8uVB-mWGUrUrJKpWtSskI6fDJJrLNF9Zs6aaFDlysQehW9bv1P27-jfsGjJSSlg</recordid><startdate>20050301</startdate><enddate>20050301</enddate><creator>Yang, Shu-Wei</creator><creator>Chan, Tze-Ming</creator><creator>Terracciano, Joseph</creator><creator>Patel, Reena</creator><creator>Loebenberg, David</creator><creator>Chen, Guodong</creator><creator>Patel, Mahesh</creator><creator>Gullo, Vincent</creator><creator>Pramanik, Birendra</creator><creator>Chu, Min</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7T7</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20050301</creationdate><title>New Antibiotic Sch 725424 and Its Dehydration Product Sch 725428 from Kitasatospora sp</title><author>Yang, Shu-Wei ; Chan, Tze-Ming ; Terracciano, Joseph ; Patel, Reena ; Loebenberg, David ; Chen, Guodong ; Patel, Mahesh ; Gullo, Vincent ; Pramanik, Birendra ; Chu, Min</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c445t-cfe56291d06dceab3a813dacfa3d35b6af255c33818ba5c0356f5f124eebd40e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Amides - 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pharmacology</topic><topic>Saccharomyces cerevisiae</topic><topic>Saccharomyces cerevisiae - drug effects</topic><topic>Staphylococcus aureus</topic><topic>Staphylococcus aureus - drug effects</topic><topic>Streptomycetaceae - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yang, Shu-Wei</creatorcontrib><creatorcontrib>Chan, Tze-Ming</creatorcontrib><creatorcontrib>Terracciano, Joseph</creatorcontrib><creatorcontrib>Patel, Reena</creatorcontrib><creatorcontrib>Loebenberg, David</creatorcontrib><creatorcontrib>Chen, Guodong</creatorcontrib><creatorcontrib>Patel, Mahesh</creatorcontrib><creatorcontrib>Gullo, Vincent</creatorcontrib><creatorcontrib>Pramanik, Birendra</creatorcontrib><creatorcontrib>Chu, Min</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Immunology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Science Database (ProQuest)</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of antibiotics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yang, Shu-Wei</au><au>Chan, Tze-Ming</au><au>Terracciano, Joseph</au><au>Patel, Reena</au><au>Loebenberg, David</au><au>Chen, Guodong</au><au>Patel, Mahesh</au><au>Gullo, Vincent</au><au>Pramanik, Birendra</au><au>Chu, Min</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>New Antibiotic Sch 725424 and Its Dehydration Product Sch 725428 from Kitasatospora sp</atitle><jtitle>Journal of antibiotics</jtitle><stitle>J Antibiot</stitle><addtitle>J Antibiot (Tokyo)</addtitle><date>2005-03-01</date><risdate>2005</risdate><volume>58</volume><issue>3</issue><spage>192</spage><epage>195</epage><pages>192-195</pages><issn>0021-8820</issn><eissn>1881-1469</eissn><abstract>A new microbial metabolite Sch 725424 (
1
) was isolated from the culture of
Kitasatospora
sp. The structure elucidation of
1
was accomplished based on NMR spectroscopic analyses as well as extensive structure elucidation of its dehydration product Sch 725428 (
2
). Compound
1
showed inhibitory activity against
Staphylococcus aureus
with MIC values 1∼2 µg/ml, and also displayed weak antifungal activity against
Saccharomyces cerevisiae
(PM503) with an MIC 32 µg/ml.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>15895527</pmid><doi>10.1038/ja.2005.22</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0021-8820 |
| ispartof | Journal of antibiotics, 2005-03, Vol.58 (3), p.192-195 |
| issn | 0021-8820 1881-1469 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_67836767 |
| source | MEDLINE; EZB Electronic Journals Library |
| subjects | Amides - chemistry Amides - metabolism Amides - pharmacology Anti-Bacterial Agents - biosynthesis Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology Antifungal Agents - chemistry Antifungal Agents - metabolism Antifungal Agents - pharmacology Bacteriology Biomedical and Life Sciences Bioorganic Chemistry Dehydration Fermentation Furans - chemistry Furans - metabolism Furans - pharmacology Kitasatospora Life Sciences Magnetic Resonance Spectroscopy Medicinal Chemistry Metabolites Microbial Sensitivity Tests Microbiology Molecular Structure Organic Chemistry Polyenes - chemistry Polyenes - metabolism Polyenes - pharmacology Saccharomyces cerevisiae Saccharomyces cerevisiae - drug effects Staphylococcus aureus Staphylococcus aureus - drug effects Streptomycetaceae - metabolism |
| title | New Antibiotic Sch 725424 and Its Dehydration Product Sch 725428 from Kitasatospora sp |
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