Bimodal cell populations are common in chronic lymphocytic leukemia but do not impact overall survival
Flow cytometric histograms were evaluated for bimodal antigen expression on samples from 246 patients diagnosed with chronic lymphocytic leukemia (CLL) at University Hospitals of Cleveland, Cleveland, OH. Survival data were obtained, and the clinical significance of bimodality was evaluated using th...
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| Veröffentlicht in: | American journal of clinical pathology 2005-06, Vol.123 (6), p.818-825 |
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| container_title | American journal of clinical pathology |
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| creator | COCCO, Amy E OSEI, Ebenezer S THUT, Dawn M EDINGER, Alison K POWERS, Jennifer J PINGFU FU MEYERSON, Howard J |
| description | Flow cytometric histograms were evaluated for bimodal antigen expression on samples from 246 patients diagnosed with chronic lymphocytic leukemia (CLL) at University Hospitals of Cleveland, Cleveland, OH. Survival data were obtained, and the clinical significance of bimodality was evaluated using the Kaplan-Meier method and the log-rank test. Bimodal antigen expression was found in 107 cases (43.5%). CD38 and CD13 were the most common antigens to demonstrate bimodality at 14.5% and 12.9%, respectively, and CD20, CD11c, CD5, FMC-7, and surface immunoglobulin also were frequently bimodal. Bimodal antigen expression, the number of bimodal antigens, and bimodality of a specific antigen were not associated with decreased survival in patients with CLL, although bimodality for CD38 trended toward worse overall survival. Therefore, although bimodal antigen expression is common in CLL, the presence of bimodality does not seem to have significant prognostic importance |
| doi_str_mv | 10.1309/14XKERAYLUL3H2HT |
| format | Article |
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Survival data were obtained, and the clinical significance of bimodality was evaluated using the Kaplan-Meier method and the log-rank test. Bimodal antigen expression was found in 107 cases (43.5%). CD38 and CD13 were the most common antigens to demonstrate bimodality at 14.5% and 12.9%, respectively, and CD20, CD11c, CD5, FMC-7, and surface immunoglobulin also were frequently bimodal. Bimodal antigen expression, the number of bimodal antigens, and bimodality of a specific antigen were not associated with decreased survival in patients with CLL, although bimodality for CD38 trended toward worse overall survival. Therefore, although bimodal antigen expression is common in CLL, the presence of bimodality does not seem to have significant prognostic importance</description><identifier>ISSN: 0002-9173</identifier><identifier>EISSN: 1943-7722</identifier><identifier>DOI: 10.1309/14XKERAYLUL3H2HT</identifier><identifier>PMID: 15899771</identifier><identifier>CODEN: AJCPAI</identifier><language>eng</language><publisher>Chicago, IL: American Society of Clinical Pathologists</publisher><subject>ADP-ribosyl Cyclase - biosynthesis ; ADP-ribosyl Cyclase 1 ; Adult ; Aged ; Aged, 80 and over ; Antigens, CD - biosynthesis ; Antigens, CD20 - biosynthesis ; Biological and medical sciences ; Biomarkers, Tumor - analysis ; CD11c Antigen - biosynthesis ; CD13 Antigens - biosynthesis ; CD5 Antigens - biosynthesis ; Female ; Flow Cytometry ; Hematologic and hematopoietic diseases ; Humans ; Immunophenotyping ; Investigative techniques, diagnostic techniques (general aspects) ; Leukemia, Lymphocytic, Chronic, B-Cell - immunology ; Leukemia, Lymphocytic, Chronic, B-Cell - mortality ; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis ; Male ; Medical sciences ; Membrane Glycoproteins ; Middle Aged ; Pathology. Cytology. Biochemistry. Spectrometry. 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Survival data were obtained, and the clinical significance of bimodality was evaluated using the Kaplan-Meier method and the log-rank test. Bimodal antigen expression was found in 107 cases (43.5%). CD38 and CD13 were the most common antigens to demonstrate bimodality at 14.5% and 12.9%, respectively, and CD20, CD11c, CD5, FMC-7, and surface immunoglobulin also were frequently bimodal. Bimodal antigen expression, the number of bimodal antigens, and bimodality of a specific antigen were not associated with decreased survival in patients with CLL, although bimodality for CD38 trended toward worse overall survival. Therefore, although bimodal antigen expression is common in CLL, the presence of bimodality does not seem to have significant prognostic importance</description><subject>ADP-ribosyl Cyclase - biosynthesis</subject><subject>ADP-ribosyl Cyclase 1</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Antigens, CD - biosynthesis</subject><subject>Antigens, CD20 - biosynthesis</subject><subject>Biological and medical sciences</subject><subject>Biomarkers, Tumor - analysis</subject><subject>CD11c Antigen - biosynthesis</subject><subject>CD13 Antigens - biosynthesis</subject><subject>CD5 Antigens - biosynthesis</subject><subject>Female</subject><subject>Flow Cytometry</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Humans</subject><subject>Immunophenotyping</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Leukemia, Lymphocytic, Chronic, B-Cell - immunology</subject><subject>Leukemia, Lymphocytic, Chronic, B-Cell - mortality</subject><subject>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Membrane Glycoproteins</subject><subject>Middle Aged</subject><subject>Pathology. Cytology. Biochemistry. Spectrometry. 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Malignant lymphomas. Malignant reticulosis. Myelofibrosis</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Membrane Glycoproteins</topic><topic>Middle Aged</topic><topic>Pathology. Cytology. Biochemistry. Spectrometry. 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Survival data were obtained, and the clinical significance of bimodality was evaluated using the Kaplan-Meier method and the log-rank test. Bimodal antigen expression was found in 107 cases (43.5%). CD38 and CD13 were the most common antigens to demonstrate bimodality at 14.5% and 12.9%, respectively, and CD20, CD11c, CD5, FMC-7, and surface immunoglobulin also were frequently bimodal. Bimodal antigen expression, the number of bimodal antigens, and bimodality of a specific antigen were not associated with decreased survival in patients with CLL, although bimodality for CD38 trended toward worse overall survival. Therefore, although bimodal antigen expression is common in CLL, the presence of bimodality does not seem to have significant prognostic importance</abstract><cop>Chicago, IL</cop><pub>American Society of Clinical Pathologists</pub><pmid>15899771</pmid><doi>10.1309/14XKERAYLUL3H2HT</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | ADP-ribosyl Cyclase - biosynthesis ADP-ribosyl Cyclase 1 Adult Aged Aged, 80 and over Antigens, CD - biosynthesis Antigens, CD20 - biosynthesis Biological and medical sciences Biomarkers, Tumor - analysis CD11c Antigen - biosynthesis CD13 Antigens - biosynthesis CD5 Antigens - biosynthesis Female Flow Cytometry Hematologic and hematopoietic diseases Humans Immunophenotyping Investigative techniques, diagnostic techniques (general aspects) Leukemia, Lymphocytic, Chronic, B-Cell - immunology Leukemia, Lymphocytic, Chronic, B-Cell - mortality Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Male Medical sciences Membrane Glycoproteins Middle Aged Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Prognosis Retrospective Studies |
| title | Bimodal cell populations are common in chronic lymphocytic leukemia but do not impact overall survival |
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