Anti-tumor effects of herbal medicines on endometrial carcinomas via estrogen receptor-α-related mechanism
This study was performed to examine the relationship between the anti-tumor effects of herbal medicine and endometrial carcinoma with ER-related mechanisms. An endometrial cancer cell line (Ishikawa) was used for this study. The cell viability and expression of estrogen receptors (ER) were determine...
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| Veröffentlicht in: | Oncology reports 2006-05, Vol.15 (5), p.1131-1136 |
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| container_title | Oncology reports |
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| creator | LIAN, Zenglin NIWA, Kenji ONOGI, Kyoko MORI, Hideki HARRIGAN, Rosanne C TAMAYA, Teruhiko |
| description | This study was performed to examine the relationship between the anti-tumor effects of herbal medicine and endometrial carcinoma with ER-related mechanisms. An endometrial cancer cell line (Ishikawa) was used for this study. The cell viability and expression of estrogen receptors (ER) were determined by MTT and RT-PCR. A dose-dependent decrease of viability and apoptosis of the cancer cells was generated by exposure to the herbal medicines, Juzen-taiho-to or Shimotsu-to. The expression of ER-alpha mRNA, but not ER-beta mRNA was suppressed by Juzen-taiho-to or Shimotsu-to in an endometrial cancer cell line. The anti-tumor effect of these herbal medicines against endometrial carcinoma might be correlated to the ER-alpha related mechanism. |
| doi_str_mv | 10.3892/or.15.5.1133 |
| format | Article |
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An endometrial cancer cell line (Ishikawa) was used for this study. The cell viability and expression of estrogen receptors (ER) were determined by MTT and RT-PCR. A dose-dependent decrease of viability and apoptosis of the cancer cells was generated by exposure to the herbal medicines, Juzen-taiho-to or Shimotsu-to. The expression of ER-alpha mRNA, but not ER-beta mRNA was suppressed by Juzen-taiho-to or Shimotsu-to in an endometrial cancer cell line. The anti-tumor effect of these herbal medicines against endometrial carcinoma might be correlated to the ER-alpha related mechanism.</description><identifier>ISSN: 1021-335X</identifier><identifier>EISSN: 1791-2431</identifier><identifier>DOI: 10.3892/or.15.5.1133</identifier><identifier>PMID: 16596174</identifier><language>eng</language><publisher>Athens: S.n.</publisher><subject>Antineoplastic Agents - therapeutic use ; Apoptosis - drug effects ; Biological and medical sciences ; Cell Survival - drug effects ; Drugs, Chinese Herbal - therapeutic use ; Endometrial Neoplasms - drug therapy ; Endometrial Neoplasms - metabolism ; Endometrial Neoplasms - pathology ; Estrogen Receptor alpha - genetics ; Estrogen Receptor alpha - metabolism ; Estrogen Receptor beta - genetics ; Estrogen Receptor beta - metabolism ; Female ; Female genital diseases ; Gynecology. Andrology. 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An endometrial cancer cell line (Ishikawa) was used for this study. The cell viability and expression of estrogen receptors (ER) were determined by MTT and RT-PCR. A dose-dependent decrease of viability and apoptosis of the cancer cells was generated by exposure to the herbal medicines, Juzen-taiho-to or Shimotsu-to. The expression of ER-alpha mRNA, but not ER-beta mRNA was suppressed by Juzen-taiho-to or Shimotsu-to in an endometrial cancer cell line. The anti-tumor effect of these herbal medicines against endometrial carcinoma might be correlated to the ER-alpha related mechanism.</description><subject>Antineoplastic Agents - therapeutic use</subject><subject>Apoptosis - drug effects</subject><subject>Biological and medical sciences</subject><subject>Cell Survival - drug effects</subject><subject>Drugs, Chinese Herbal - therapeutic use</subject><subject>Endometrial Neoplasms - drug therapy</subject><subject>Endometrial Neoplasms - metabolism</subject><subject>Endometrial Neoplasms - pathology</subject><subject>Estrogen Receptor alpha - genetics</subject><subject>Estrogen Receptor alpha - metabolism</subject><subject>Estrogen Receptor beta - genetics</subject><subject>Estrogen Receptor beta - metabolism</subject><subject>Female</subject><subject>Female genital diseases</subject><subject>Gynecology. Andrology. 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Andrology. 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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Antineoplastic Agents - therapeutic use Apoptosis - drug effects Biological and medical sciences Cell Survival - drug effects Drugs, Chinese Herbal - therapeutic use Endometrial Neoplasms - drug therapy Endometrial Neoplasms - metabolism Endometrial Neoplasms - pathology Estrogen Receptor alpha - genetics Estrogen Receptor alpha - metabolism Estrogen Receptor beta - genetics Estrogen Receptor beta - metabolism Female Female genital diseases Gynecology. Andrology. Obstetrics Herbal Medicine Humans Medical sciences Reverse Transcriptase Polymerase Chain Reaction Tumor Cells, Cultured Tumors |
| title | Anti-tumor effects of herbal medicines on endometrial carcinomas via estrogen receptor-α-related mechanism |
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