Harmonization of the Bayer ADVIA Centaur and Abbott AxSYM automated B-type natriuretic peptide assay in patients on hemodialysis
There are two fully automated high-throughput clinical instruments for brain natriuretic peptide (BNP) assays, the Bayer ADVIA Centaur assay, and the Abbott AxSYM assay. Although both recommend a cut-off value of 100pg/mL, we are unaware of previous studies that have compared the unadjusted results...
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| Veröffentlicht in: | Clinical chemistry and laboratory medicine 2005-01, Vol.43 (5), p.554-556 |
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| creator | Barak, Mira Weinberger, Ronit Marcusohn, Jerom Froom, Paul |
| description | There are two fully automated high-throughput clinical instruments for brain natriuretic peptide (BNP) assays, the Bayer ADVIA Centaur assay, and the Abbott AxSYM assay. Although both recommend a cut-off value of 100pg/mL, we are unaware of previous studies that have compared the unadjusted results of the two methods, required for proper evaluation of patients undergoing this test on different platforms. From 43 hemodialysis patients, 80 paired samples were collected by venipuncture into plastic evacuated tubes containing EDTA. The Bayer assay yielded lower values than the Abbott assay, with linear regression of 0.53×Abbott assay (95% confidence interval, 0.50–0.56) being forced through 0, demonstrating an r
-value of 0.954. Regression for the Abbott assay was 1.79×Bayer assay (95% CI, 1.69–1.89). The cut-off values for abnormal BNP results analyzed on the Abbott system are not identical to those on the Bayer system, and this needs to be taken into account when comparing studies on the clinical utility of these systems. |
| doi_str_mv | 10.1515/CCLM.2005.096 |
| format | Article |
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-value of 0.954. Regression for the Abbott assay was 1.79×Bayer assay (95% CI, 1.69–1.89). The cut-off values for abnormal BNP results analyzed on the Abbott system are not identical to those on the Bayer system, and this needs to be taken into account when comparing studies on the clinical utility of these systems.</description><identifier>ISSN: 1434-6621</identifier><identifier>EISSN: 1437-4331</identifier><identifier>DOI: 10.1515/CCLM.2005.096</identifier><identifier>PMID: 15899679</identifier><language>eng</language><publisher>Berlin: De Gruyter</publisher><subject>Abbott ; Adult ; Aged ; Aged, 80 and over ; automated ; Automation ; Bayer ; Biological and medical sciences ; Blood Chemical Analysis - methods ; Blood Chemical Analysis - statistics & numerical data ; brain natriuretic peptide ; Female ; General aspects ; harmonization ; Humans ; Investigative techniques, diagnostic techniques (general aspects) ; Male ; Medical sciences ; Middle Aged ; Natriuretic Peptide, Brain - blood ; reference range ; Reference Values ; Regression Analysis ; Renal Dialysis</subject><ispartof>Clinical chemistry and laboratory medicine, 2005-01, Vol.43 (5), p.554-556</ispartof><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c373t-44d275948fd190141460e0ce5c4d37a8a2921be8327bc75f76cc95b4e222e06e3</citedby><cites>FETCH-LOGICAL-c373t-44d275948fd190141460e0ce5c4d37a8a2921be8327bc75f76cc95b4e222e06e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.degruyter.com/document/doi/10.1515/CCLM.2005.096/pdf$$EPDF$$P50$$Gwalterdegruyter$$H</linktopdf><linktohtml>$$Uhttps://www.degruyter.com/document/doi/10.1515/CCLM.2005.096/html$$EHTML$$P50$$Gwalterdegruyter$$H</linktohtml><link.rule.ids>309,310,314,776,780,785,786,23909,23910,25118,27901,27902,66725,68509</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16801454$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15899679$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Barak, Mira</creatorcontrib><creatorcontrib>Weinberger, Ronit</creatorcontrib><creatorcontrib>Marcusohn, Jerom</creatorcontrib><creatorcontrib>Froom, Paul</creatorcontrib><title>Harmonization of the Bayer ADVIA Centaur and Abbott AxSYM automated B-type natriuretic peptide assay in patients on hemodialysis</title><title>Clinical chemistry and laboratory medicine</title><addtitle>Clin Chem Lab Med</addtitle><description>There are two fully automated high-throughput clinical instruments for brain natriuretic peptide (BNP) assays, the Bayer ADVIA Centaur assay, and the Abbott AxSYM assay. Although both recommend a cut-off value of 100pg/mL, we are unaware of previous studies that have compared the unadjusted results of the two methods, required for proper evaluation of patients undergoing this test on different platforms. From 43 hemodialysis patients, 80 paired samples were collected by venipuncture into plastic evacuated tubes containing EDTA. The Bayer assay yielded lower values than the Abbott assay, with linear regression of 0.53×Abbott assay (95% confidence interval, 0.50–0.56) being forced through 0, demonstrating an r
-value of 0.954. Regression for the Abbott assay was 1.79×Bayer assay (95% CI, 1.69–1.89). The cut-off values for abnormal BNP results analyzed on the Abbott system are not identical to those on the Bayer system, and this needs to be taken into account when comparing studies on the clinical utility of these systems.</description><subject>Abbott</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>automated</subject><subject>Automation</subject><subject>Bayer</subject><subject>Biological and medical sciences</subject><subject>Blood Chemical Analysis - methods</subject><subject>Blood Chemical Analysis - statistics & numerical data</subject><subject>brain natriuretic peptide</subject><subject>Female</subject><subject>General aspects</subject><subject>harmonization</subject><subject>Humans</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Natriuretic Peptide, Brain - blood</subject><subject>reference range</subject><subject>Reference Values</subject><subject>Regression Analysis</subject><subject>Renal Dialysis</subject><issn>1434-6621</issn><issn>1437-4331</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkU1v1DAQhi0EomXhyBX5ArcsdmzHiThtQ6GVtuLAh8QpmjgT6iqJg-2IhhM_HS-7Ui9cxnN49M7MY0Jecrbliqu3db2_2eaMqS2rikfknEuhMykEf_yvl1lR5PyMPAvhjjGulNRPyRlXZVUVujonf67Aj26yvyFaN1HX03iL9AJW9HT3_tv1jtY4RVg8hamju7Z1MdLd_efvNxSW6EaI2NGLLK4z0gmit4vHaA2dcY62QwohwErtROc0ICUFmqbc4ug6C8MabHhOnvQwBHxxejfk64fLL_VVtv_08bre7TMjtIiZlF2uVSXLvuMV45LLgiEzqIzshIYS8irnLZYi163RqteFMZVqJeZ5jqxAsSFvjrmzdz8XDLEZbTA4DDChW0JT6FIokcqGZEfQeBeCx76ZvR3Brw1nzUF5c1DeHJQ3SXniX52Cl3bE7oE-OU7A6xMAwcDQe5iMDQ9cUaZ7lEzcuyP3C4aIvsMffllT09y5xU_Jzf8XkEKlXxV_ARkHnJc</recordid><startdate>20050101</startdate><enddate>20050101</enddate><creator>Barak, Mira</creator><creator>Weinberger, Ronit</creator><creator>Marcusohn, Jerom</creator><creator>Froom, Paul</creator><general>De Gruyter</general><general>Walter de Gruyter</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20050101</creationdate><title>Harmonization of the Bayer ADVIA Centaur and Abbott AxSYM automated B-type natriuretic peptide assay in patients on hemodialysis</title><author>Barak, Mira ; Weinberger, Ronit ; Marcusohn, Jerom ; Froom, Paul</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c373t-44d275948fd190141460e0ce5c4d37a8a2921be8327bc75f76cc95b4e222e06e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Abbott</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>automated</topic><topic>Automation</topic><topic>Bayer</topic><topic>Biological and medical sciences</topic><topic>Blood Chemical Analysis - methods</topic><topic>Blood Chemical Analysis - statistics & numerical data</topic><topic>brain natriuretic peptide</topic><topic>Female</topic><topic>General aspects</topic><topic>harmonization</topic><topic>Humans</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Natriuretic Peptide, Brain - blood</topic><topic>reference range</topic><topic>Reference Values</topic><topic>Regression Analysis</topic><topic>Renal Dialysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Barak, Mira</creatorcontrib><creatorcontrib>Weinberger, Ronit</creatorcontrib><creatorcontrib>Marcusohn, Jerom</creatorcontrib><creatorcontrib>Froom, Paul</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical chemistry and laboratory medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Barak, Mira</au><au>Weinberger, Ronit</au><au>Marcusohn, Jerom</au><au>Froom, Paul</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Harmonization of the Bayer ADVIA Centaur and Abbott AxSYM automated B-type natriuretic peptide assay in patients on hemodialysis</atitle><jtitle>Clinical chemistry and laboratory medicine</jtitle><addtitle>Clin Chem Lab Med</addtitle><date>2005-01-01</date><risdate>2005</risdate><volume>43</volume><issue>5</issue><spage>554</spage><epage>556</epage><pages>554-556</pages><issn>1434-6621</issn><eissn>1437-4331</eissn><abstract>There are two fully automated high-throughput clinical instruments for brain natriuretic peptide (BNP) assays, the Bayer ADVIA Centaur assay, and the Abbott AxSYM assay. Although both recommend a cut-off value of 100pg/mL, we are unaware of previous studies that have compared the unadjusted results of the two methods, required for proper evaluation of patients undergoing this test on different platforms. From 43 hemodialysis patients, 80 paired samples were collected by venipuncture into plastic evacuated tubes containing EDTA. The Bayer assay yielded lower values than the Abbott assay, with linear regression of 0.53×Abbott assay (95% confidence interval, 0.50–0.56) being forced through 0, demonstrating an r
-value of 0.954. Regression for the Abbott assay was 1.79×Bayer assay (95% CI, 1.69–1.89). The cut-off values for abnormal BNP results analyzed on the Abbott system are not identical to those on the Bayer system, and this needs to be taken into account when comparing studies on the clinical utility of these systems.</abstract><cop>Berlin</cop><cop>New York, NY</cop><pub>De Gruyter</pub><pmid>15899679</pmid><doi>10.1515/CCLM.2005.096</doi><tpages>3</tpages></addata></record> |
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| subjects | Abbott Adult Aged Aged, 80 and over automated Automation Bayer Biological and medical sciences Blood Chemical Analysis - methods Blood Chemical Analysis - statistics & numerical data brain natriuretic peptide Female General aspects harmonization Humans Investigative techniques, diagnostic techniques (general aspects) Male Medical sciences Middle Aged Natriuretic Peptide, Brain - blood reference range Reference Values Regression Analysis Renal Dialysis |
| title | Harmonization of the Bayer ADVIA Centaur and Abbott AxSYM automated B-type natriuretic peptide assay in patients on hemodialysis |
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