Genetic variation and covariation for resistance and tolerance to Cucumber mosaic virus in Mimulus guttatus (Phrymaceae): a test for costs and constraints
Genetic variation for resistance and tolerance to pathogens may be maintained by costs represented as genetic trade-offs between these traits and fitness. The evolution of resistance and tolerance also may be constrained by negative genetic correlations between these defense systems. Using a complet...
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| Veröffentlicht in: | Heredity 2006-01, Vol.96 (1), p.29-38 |
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| description | Genetic variation for resistance and tolerance to pathogens may be maintained by costs represented as genetic trade-offs between these traits and fitness. The evolution of resistance and tolerance also may be constrained by negative genetic correlations between these defense systems. Using a complete diallel, we measured genetic variation and covariation for and among performance, resistance, and tolerance traits in Mimulus guttatus challenged with a generalist pathogen, Cucumber mosaic virus (CMV). Viral coat protein was detected by enzyme-linked immunosorbent assay (ELISA) in all inoculated plants, indicating that all plants were susceptible to infection, although the ELISA absorbance varied quantitatively across plants. Plants inoculated with CMV had significantly reduced aboveground biomass and flower production relative to controls, although date of first flower was unaffected by infection. All three of these performance traits showed moderate to high narrow-sense heritability (h2=0.32-0.62) in both inoculated and control plants. We found phenotypic variation for both tolerance of and resistance to our strain of CMV, but both displayed very low narrow-sense heritability (h2 |
| doi_str_mv | 10.1038/sj.hdy.6800743 |
| format | Article |
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The evolution of resistance and tolerance also may be constrained by negative genetic correlations between these defense systems. Using a complete diallel, we measured genetic variation and covariation for and among performance, resistance, and tolerance traits in Mimulus guttatus challenged with a generalist pathogen, Cucumber mosaic virus (CMV). Viral coat protein was detected by enzyme-linked immunosorbent assay (ELISA) in all inoculated plants, indicating that all plants were susceptible to infection, although the ELISA absorbance varied quantitatively across plants. Plants inoculated with CMV had significantly reduced aboveground biomass and flower production relative to controls, although date of first flower was unaffected by infection. All three of these performance traits showed moderate to high narrow-sense heritability (h2=0.32-0.62) in both inoculated and control plants. We found phenotypic variation for both tolerance of and resistance to our strain of CMV, but both displayed very low narrow-sense heritability (h2<0.03). We found no evidence of a trade-off between resistance and tolerance. We also found no evidence for a cost of resistance or tolerance. In fact, a significant genetic correlation suggested that plants that were large when healthy had the greatest tolerance when infected. Significant, positive genetic correlations found between performance of uninfected and infected plants suggested that selection would likely favor the same M. guttatus genotypes whether CMV is present or not.</description><identifier>ISSN: 0018-067X</identifier><identifier>EISSN: 1365-2540</identifier><identifier>DOI: 10.1038/sj.hdy.6800743</identifier><identifier>PMID: 16189544</identifier><identifier>CODEN: HDTYAT</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Biological Evolution ; Biomedical and Life Sciences ; Biomedicine ; Capsid Proteins - analysis ; Cucumber mosaic virus ; Cucumovirus - pathogenicity ; Cytogenetics ; Cytomegalovirus ; disease resistance ; Ecology ; Enzyme-Linked Immunosorbent Assay ; Evolutionary Biology ; Flowers ; genetic correlation ; genetic covariation ; Genetic diversity ; Genetic Variation ; Genotypes ; heritability ; Human Genetics ; Immunity, Innate ; Inheritance Patterns ; maternal effect ; Mimulus - genetics ; Mimulus - virology ; Mimulus guttatus ; original-article ; Pathogens ; phenotypic variation ; Phenotypic variations ; Phrymaceae ; plant diseases and disorders ; Plant Genetics and Genomics ; Reproduction ; Selection, Genetic</subject><ispartof>Heredity, 2006-01, Vol.96 (1), p.29-38</ispartof><rights>The Genetics Society 2006</rights><rights>Copyright Nature Publishing Group Jan 2006</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c455t-6e35024ed92da5711e3e324d4f736f937f0b60b398242e967fab70f3d39487c13</citedby><cites>FETCH-LOGICAL-c455t-6e35024ed92da5711e3e324d4f736f937f0b60b398242e967fab70f3d39487c13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/sj.hdy.6800743$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/sj.hdy.6800743$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16189544$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Carr, D.E</creatorcontrib><creatorcontrib>Murphy, J.F</creatorcontrib><creatorcontrib>Eubanks, M.D</creatorcontrib><title>Genetic variation and covariation for resistance and tolerance to Cucumber mosaic virus in Mimulus guttatus (Phrymaceae): a test for costs and constraints</title><title>Heredity</title><addtitle>Heredity</addtitle><addtitle>Heredity (Edinb)</addtitle><description>Genetic variation for resistance and tolerance to pathogens may be maintained by costs represented as genetic trade-offs between these traits and fitness. The evolution of resistance and tolerance also may be constrained by negative genetic correlations between these defense systems. Using a complete diallel, we measured genetic variation and covariation for and among performance, resistance, and tolerance traits in Mimulus guttatus challenged with a generalist pathogen, Cucumber mosaic virus (CMV). Viral coat protein was detected by enzyme-linked immunosorbent assay (ELISA) in all inoculated plants, indicating that all plants were susceptible to infection, although the ELISA absorbance varied quantitatively across plants. Plants inoculated with CMV had significantly reduced aboveground biomass and flower production relative to controls, although date of first flower was unaffected by infection. All three of these performance traits showed moderate to high narrow-sense heritability (h2=0.32-0.62) in both inoculated and control plants. We found phenotypic variation for both tolerance of and resistance to our strain of CMV, but both displayed very low narrow-sense heritability (h2<0.03). We found no evidence of a trade-off between resistance and tolerance. We also found no evidence for a cost of resistance or tolerance. In fact, a significant genetic correlation suggested that plants that were large when healthy had the greatest tolerance when infected. Significant, positive genetic correlations found between performance of uninfected and infected plants suggested that selection would likely favor the same M. guttatus genotypes whether CMV is present or not.</description><subject>Biological Evolution</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Capsid Proteins - analysis</subject><subject>Cucumber mosaic virus</subject><subject>Cucumovirus - pathogenicity</subject><subject>Cytogenetics</subject><subject>Cytomegalovirus</subject><subject>disease resistance</subject><subject>Ecology</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Evolutionary Biology</subject><subject>Flowers</subject><subject>genetic correlation</subject><subject>genetic covariation</subject><subject>Genetic diversity</subject><subject>Genetic Variation</subject><subject>Genotypes</subject><subject>heritability</subject><subject>Human Genetics</subject><subject>Immunity, Innate</subject><subject>Inheritance Patterns</subject><subject>maternal effect</subject><subject>Mimulus - genetics</subject><subject>Mimulus - virology</subject><subject>Mimulus guttatus</subject><subject>original-article</subject><subject>Pathogens</subject><subject>phenotypic variation</subject><subject>Phenotypic variations</subject><subject>Phrymaceae</subject><subject>plant diseases and disorders</subject><subject>Plant Genetics and Genomics</subject><subject>Reproduction</subject><subject>Selection, Genetic</subject><issn>0018-067X</issn><issn>1365-2540</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFkcGKFDEQhoMo7rh69ajBg-ihZyuddNLxJoOuwoqCLngL6XR6NkN3spukhXkVn9bsTMOAIJ6qivrqryp-hJ4TWBOg7UXarW_6_Zq3AILRB2hFKG-qumHwEK0ASFsBFz_P0JOUdgBARS0fozPCSSsbxlbo96X1NjuDf-nodHbBY-17bMKpHkLE0SaXsvbGHto5jDYeqhzwZjbz1NmIp5D0vZKLc8LO4y9umseSbuecdS7Jm283cT9pY7V9-w5rnG3KB3kTUk7LYp9y1M7n9BQ9GvSY7LMlnqPrjx9-bD5VV18vP2_eX1WGNU2uuKUN1Mz2su51Iwix1NKa9WwQlA-SigE6Dh2Vbc1qK7kYdCdgoD2VrBWG0HP0-qh7G8PdXE5Sk0vGjqP2NsxJcdFS1hL5X5BIKQkwKOCrv8BdmKMvT6iaFhcYl22B1kfIxJBStIO6jW7Sca8IqHtvVdqp4q1avC0DLxbVuZtsf8IXMwtwcQRSafmtjae1_5R8eZwYdFB6G11S199rIBQISFbOpH8AzpG7NA</recordid><startdate>20060101</startdate><enddate>20060101</enddate><creator>Carr, D.E</creator><creator>Murphy, J.F</creator><creator>Eubanks, M.D</creator><general>Springer International Publishing</general><general>Springer Nature B.V</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7SN</scope><scope>7SS</scope><scope>7T7</scope><scope>7TK</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M2P</scope><scope>M7N</scope><scope>M7P</scope><scope>MBDVC</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20060101</creationdate><title>Genetic variation and covariation for resistance and tolerance to Cucumber mosaic virus in Mimulus guttatus (Phrymaceae): a test for costs and constraints</title><author>Carr, D.E ; Murphy, J.F ; Eubanks, M.D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c455t-6e35024ed92da5711e3e324d4f736f937f0b60b398242e967fab70f3d39487c13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Biological Evolution</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Capsid Proteins - analysis</topic><topic>Cucumber mosaic virus</topic><topic>Cucumovirus - pathogenicity</topic><topic>Cytogenetics</topic><topic>Cytomegalovirus</topic><topic>disease resistance</topic><topic>Ecology</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>Evolutionary Biology</topic><topic>Flowers</topic><topic>genetic correlation</topic><topic>genetic covariation</topic><topic>Genetic diversity</topic><topic>Genetic Variation</topic><topic>Genotypes</topic><topic>heritability</topic><topic>Human Genetics</topic><topic>Immunity, Innate</topic><topic>Inheritance Patterns</topic><topic>maternal effect</topic><topic>Mimulus - genetics</topic><topic>Mimulus - virology</topic><topic>Mimulus guttatus</topic><topic>original-article</topic><topic>Pathogens</topic><topic>phenotypic variation</topic><topic>Phenotypic variations</topic><topic>Phrymaceae</topic><topic>plant diseases and disorders</topic><topic>Plant Genetics and Genomics</topic><topic>Reproduction</topic><topic>Selection, Genetic</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Carr, D.E</creatorcontrib><creatorcontrib>Murphy, J.F</creatorcontrib><creatorcontrib>Eubanks, M.D</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Science Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Heredity</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Carr, D.E</au><au>Murphy, J.F</au><au>Eubanks, M.D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Genetic variation and covariation for resistance and tolerance to Cucumber mosaic virus in Mimulus guttatus (Phrymaceae): a test for costs and constraints</atitle><jtitle>Heredity</jtitle><stitle>Heredity</stitle><addtitle>Heredity (Edinb)</addtitle><date>2006-01-01</date><risdate>2006</risdate><volume>96</volume><issue>1</issue><spage>29</spage><epage>38</epage><pages>29-38</pages><issn>0018-067X</issn><eissn>1365-2540</eissn><coden>HDTYAT</coden><abstract>Genetic variation for resistance and tolerance to pathogens may be maintained by costs represented as genetic trade-offs between these traits and fitness. The evolution of resistance and tolerance also may be constrained by negative genetic correlations between these defense systems. Using a complete diallel, we measured genetic variation and covariation for and among performance, resistance, and tolerance traits in Mimulus guttatus challenged with a generalist pathogen, Cucumber mosaic virus (CMV). Viral coat protein was detected by enzyme-linked immunosorbent assay (ELISA) in all inoculated plants, indicating that all plants were susceptible to infection, although the ELISA absorbance varied quantitatively across plants. Plants inoculated with CMV had significantly reduced aboveground biomass and flower production relative to controls, although date of first flower was unaffected by infection. All three of these performance traits showed moderate to high narrow-sense heritability (h2=0.32-0.62) in both inoculated and control plants. We found phenotypic variation for both tolerance of and resistance to our strain of CMV, but both displayed very low narrow-sense heritability (h2<0.03). We found no evidence of a trade-off between resistance and tolerance. We also found no evidence for a cost of resistance or tolerance. In fact, a significant genetic correlation suggested that plants that were large when healthy had the greatest tolerance when infected. Significant, positive genetic correlations found between performance of uninfected and infected plants suggested that selection would likely favor the same M. guttatus genotypes whether CMV is present or not.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>16189544</pmid><doi>10.1038/sj.hdy.6800743</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Biological Evolution Biomedical and Life Sciences Biomedicine Capsid Proteins - analysis Cucumber mosaic virus Cucumovirus - pathogenicity Cytogenetics Cytomegalovirus disease resistance Ecology Enzyme-Linked Immunosorbent Assay Evolutionary Biology Flowers genetic correlation genetic covariation Genetic diversity Genetic Variation Genotypes heritability Human Genetics Immunity, Innate Inheritance Patterns maternal effect Mimulus - genetics Mimulus - virology Mimulus guttatus original-article Pathogens phenotypic variation Phenotypic variations Phrymaceae plant diseases and disorders Plant Genetics and Genomics Reproduction Selection, Genetic |
| title | Genetic variation and covariation for resistance and tolerance to Cucumber mosaic virus in Mimulus guttatus (Phrymaceae): a test for costs and constraints |
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