Berberry Extract Reduces Neuronal Damage and N-Methyl-D-aspartate Receptor 1 Immunoreactivity in the Gerbil Hippocampus after Transient Forebrain Ischemia
In the present study, we studied the neuroprotective effects of berberry extract (BE) against ischemic damage and the temporal and spatial alterations of N-methyl-D-aspartate receptor type 1 (NR1) and NR2A/2B immunoreactivities in the gerbil hippocampal CA1 region after transient ischemia to examine...
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| Veröffentlicht in: | Biological & Pharmaceutical Bulletin 2006, Vol.29(4), pp.623-628 |
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| creator | Yoo, Ki-Yeon Hwang, In Koo Lim, Beong Ou Kang, Tae-Cheon Kim, Dong-Woo Kim, Sang Moo Lee, Hyeon Yong Kim, Jong Dai Won, Moo Ho |
| description | In the present study, we studied the neuroprotective effects of berberry extract (BE) against ischemic damage and the temporal and spatial alterations of N-methyl-D-aspartate receptor type 1 (NR1) and NR2A/2B immunoreactivities in the gerbil hippocampal CA1 region after transient ischemia to examine anti-ischemic effects and its role in transient forebrain ischemia. In the vehicle-treated group, the percentage of cresyl violet positive pyramidal cells in the CA1 region was about 11.4% compared to the sham-operated group 4 d after ischemic insult. BE showed neuroprotective effects against ischemic damage after ischemia-reperfusion. In the BE-treated groups, about 60—75% of CA1 pyramidal cells were stained with cresyl violet 4 d after ischemic insult. We observed the percentage of berberine (7.45+0.85 mg/g in BE) by HPLC, which is active ingredient of BE. NR1 immunoreactivity in the stratum pyramidale of the CA1 region in the vehicle-treated group was significantly increased at 30 min after transient forebrain ischemia, while at this time the NR1 immunoreactivity in the BE-treated groups was significantly low compared to the vehicle-treated group. The pattern of NR2A/B immunoreactivity in the stratum pyramidale of the BE-treated group and its protein levels were similar to that in the vehicle-treated group after ischemic insult. These results suggest that BE has potent neuroprotective effects against ischemic damage via the reduction of NR1 activity. |
| doi_str_mv | 10.1248/bpb.29.623 |
| format | Article |
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In the vehicle-treated group, the percentage of cresyl violet positive pyramidal cells in the CA1 region was about 11.4% compared to the sham-operated group 4 d after ischemic insult. BE showed neuroprotective effects against ischemic damage after ischemia-reperfusion. In the BE-treated groups, about 60—75% of CA1 pyramidal cells were stained with cresyl violet 4 d after ischemic insult. We observed the percentage of berberine (7.45+0.85 mg/g in BE) by HPLC, which is active ingredient of BE. NR1 immunoreactivity in the stratum pyramidale of the CA1 region in the vehicle-treated group was significantly increased at 30 min after transient forebrain ischemia, while at this time the NR1 immunoreactivity in the BE-treated groups was significantly low compared to the vehicle-treated group. The pattern of NR2A/B immunoreactivity in the stratum pyramidale of the BE-treated group and its protein levels were similar to that in the vehicle-treated group after ischemic insult. These results suggest that BE has potent neuroprotective effects against ischemic damage via the reduction of NR1 activity.</description><identifier>ISSN: 0918-6158</identifier><identifier>EISSN: 1347-5215</identifier><identifier>DOI: 10.1248/bpb.29.623</identifier><identifier>PMID: 16595891</identifier><language>eng</language><publisher>Japan: The Pharmaceutical Society of Japan</publisher><subject>Animals ; Benzoxazines ; Berberine - analysis ; Berberine - pharmacology ; Berberis - chemistry ; berberry extract ; Blotting, Western ; Cell Death - drug effects ; Chromatography, High Pressure Liquid ; gerbil ; Gerbillinae ; hippocampal CA1 region ; Hippocampus - metabolism ; Hippocampus - pathology ; Immunohistochemistry ; Indicators and Reagents ; Ischemic Attack, Transient - metabolism ; Ischemic Attack, Transient - pathology ; Male ; N-methyl-D-aspartate receptor ; Neurons - pathology ; neuroprotection ; Neuroprotective Agents - pharmacology ; Oxazines ; Plant Extracts - pharmacology ; Receptors, N-Methyl-D-Aspartate - metabolism ; Reference Standards ; transient forebrain ischemia</subject><ispartof>Biological and Pharmaceutical Bulletin, 2006, Vol.29(4), pp.623-628</ispartof><rights>2006 The Pharmaceutical Society of Japan</rights><rights>Copyright Japan Science and Technology Agency 2006</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c684t-bfd4033ce7abaa9676d0eb7e7f79fee1a0d063d1c10290ecab2901a0104b30003</citedby><cites>FETCH-LOGICAL-c684t-bfd4033ce7abaa9676d0eb7e7f79fee1a0d063d1c10290ecab2901a0104b30003</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1883,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16595891$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yoo, Ki-Yeon</creatorcontrib><creatorcontrib>Hwang, In Koo</creatorcontrib><creatorcontrib>Lim, Beong Ou</creatorcontrib><creatorcontrib>Kang, Tae-Cheon</creatorcontrib><creatorcontrib>Kim, Dong-Woo</creatorcontrib><creatorcontrib>Kim, Sang Moo</creatorcontrib><creatorcontrib>Lee, Hyeon Yong</creatorcontrib><creatorcontrib>Kim, Jong Dai</creatorcontrib><creatorcontrib>Won, Moo Ho</creatorcontrib><creatorcontrib>College of Medicine</creatorcontrib><creatorcontrib>Konkuk University</creatorcontrib><creatorcontrib>bNatural F&P Co</creatorcontrib><creatorcontrib>cDepartment of Applied Biochemistry</creatorcontrib><creatorcontrib>dFaculty of Marine Bioscience and Technology</creatorcontrib><creatorcontrib>LTD</creatorcontrib><creatorcontrib>aDepartment of Anatomy</creatorcontrib><creatorcontrib>Hallym University</creatorcontrib><creatorcontrib>Kangwon National University</creatorcontrib><creatorcontrib>eSchool of Biotechnology and Bioengineering</creatorcontrib><creatorcontrib>Kangnung National University</creatorcontrib><title>Berberry Extract Reduces Neuronal Damage and N-Methyl-D-aspartate Receptor 1 Immunoreactivity in the Gerbil Hippocampus after Transient Forebrain Ischemia</title><title>Biological & Pharmaceutical Bulletin</title><addtitle>Biol Pharm Bull</addtitle><description>In the present study, we studied the neuroprotective effects of berberry extract (BE) against ischemic damage and the temporal and spatial alterations of N-methyl-D-aspartate receptor type 1 (NR1) and NR2A/2B immunoreactivities in the gerbil hippocampal CA1 region after transient ischemia to examine anti-ischemic effects and its role in transient forebrain ischemia. In the vehicle-treated group, the percentage of cresyl violet positive pyramidal cells in the CA1 region was about 11.4% compared to the sham-operated group 4 d after ischemic insult. BE showed neuroprotective effects against ischemic damage after ischemia-reperfusion. In the BE-treated groups, about 60—75% of CA1 pyramidal cells were stained with cresyl violet 4 d after ischemic insult. We observed the percentage of berberine (7.45+0.85 mg/g in BE) by HPLC, which is active ingredient of BE. NR1 immunoreactivity in the stratum pyramidale of the CA1 region in the vehicle-treated group was significantly increased at 30 min after transient forebrain ischemia, while at this time the NR1 immunoreactivity in the BE-treated groups was significantly low compared to the vehicle-treated group. The pattern of NR2A/B immunoreactivity in the stratum pyramidale of the BE-treated group and its protein levels were similar to that in the vehicle-treated group after ischemic insult. These results suggest that BE has potent neuroprotective effects against ischemic damage via the reduction of NR1 activity.</description><subject>Animals</subject><subject>Benzoxazines</subject><subject>Berberine - analysis</subject><subject>Berberine - pharmacology</subject><subject>Berberis - chemistry</subject><subject>berberry extract</subject><subject>Blotting, Western</subject><subject>Cell Death - drug effects</subject><subject>Chromatography, High Pressure Liquid</subject><subject>gerbil</subject><subject>Gerbillinae</subject><subject>hippocampal CA1 region</subject><subject>Hippocampus - metabolism</subject><subject>Hippocampus - pathology</subject><subject>Immunohistochemistry</subject><subject>Indicators and Reagents</subject><subject>Ischemic Attack, Transient - metabolism</subject><subject>Ischemic Attack, Transient - pathology</subject><subject>Male</subject><subject>N-methyl-D-aspartate receptor</subject><subject>Neurons - pathology</subject><subject>neuroprotection</subject><subject>Neuroprotective Agents - pharmacology</subject><subject>Oxazines</subject><subject>Plant Extracts - pharmacology</subject><subject>Receptors, N-Methyl-D-Aspartate - metabolism</subject><subject>Reference Standards</subject><subject>transient forebrain ischemia</subject><issn>0918-6158</issn><issn>1347-5215</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkcFu1DAQhiMEokvhwgMgS0gcKmWxY8dJTgjabrtSKRIqZ2vsTFivkji1HdR9FZ4WL7ulEpcZy_PNP_b8WfaW0SUrRP1RT3pZNEtZ8GfZgnFR5WXByufZgjasziUr65PsVQhbSmlFC_4yO2GybMq6YYvs9xf0Gr3fkcuH6MFE8h3b2WAgtzh7N0JPLmCAn0hgbMlt_hXjZtfnFzmECXyEiKnB4BSdJ4ysh2EencekY3_ZuCN2JHGD5CoNsT25ttPkDAzTHAh0ET258zAGi2Mkq9SmPaSGdTAbHCy8zl500Ad8c8yn2Y_V5d35dX7z7Wp9_vkmN7IWMdddKyjnBivQAI2sZEtRV1h1VdMhMqAtlbxlhtGioWhAp5RuGRWap5Xw0-zDQXfy7n7GENVgg8G-hxHdHJSsai5KWSfw_X_g1s0-rSgoJkTDy1rUMlFnB8p4F4LHTk3eDuB3ilG190slv1TRqORXgt8dJWc9YPuEHg1KwOoApKo10LuxtyM-DTah0tb1ThWUSkX3XxTq7zHJ70PNpZRVkYQ-HYS2ISY7_01KJlrT4-OjxCHsmx8rZgNe4cj_ANsVv74</recordid><startdate>20060401</startdate><enddate>20060401</enddate><creator>Yoo, Ki-Yeon</creator><creator>Hwang, In Koo</creator><creator>Lim, Beong Ou</creator><creator>Kang, Tae-Cheon</creator><creator>Kim, Dong-Woo</creator><creator>Kim, Sang Moo</creator><creator>Lee, Hyeon Yong</creator><creator>Kim, Jong Dai</creator><creator>Won, Moo Ho</creator><general>The Pharmaceutical Society of Japan</general><general>Pharmaceutical Society of Japan</general><general>Japan Science and Technology Agency</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7U9</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20060401</creationdate><title>Berberry Extract Reduces Neuronal Damage and N-Methyl-D-aspartate Receptor 1 Immunoreactivity in the Gerbil Hippocampus after Transient Forebrain Ischemia</title><author>Yoo, Ki-Yeon ; 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In the vehicle-treated group, the percentage of cresyl violet positive pyramidal cells in the CA1 region was about 11.4% compared to the sham-operated group 4 d after ischemic insult. BE showed neuroprotective effects against ischemic damage after ischemia-reperfusion. In the BE-treated groups, about 60—75% of CA1 pyramidal cells were stained with cresyl violet 4 d after ischemic insult. We observed the percentage of berberine (7.45+0.85 mg/g in BE) by HPLC, which is active ingredient of BE. NR1 immunoreactivity in the stratum pyramidale of the CA1 region in the vehicle-treated group was significantly increased at 30 min after transient forebrain ischemia, while at this time the NR1 immunoreactivity in the BE-treated groups was significantly low compared to the vehicle-treated group. The pattern of NR2A/B immunoreactivity in the stratum pyramidale of the BE-treated group and its protein levels were similar to that in the vehicle-treated group after ischemic insult. These results suggest that BE has potent neuroprotective effects against ischemic damage via the reduction of NR1 activity.</abstract><cop>Japan</cop><pub>The Pharmaceutical Society of Japan</pub><pmid>16595891</pmid><doi>10.1248/bpb.29.623</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Benzoxazines Berberine - analysis Berberine - pharmacology Berberis - chemistry berberry extract Blotting, Western Cell Death - drug effects Chromatography, High Pressure Liquid gerbil Gerbillinae hippocampal CA1 region Hippocampus - metabolism Hippocampus - pathology Immunohistochemistry Indicators and Reagents Ischemic Attack, Transient - metabolism Ischemic Attack, Transient - pathology Male N-methyl-D-aspartate receptor Neurons - pathology neuroprotection Neuroprotective Agents - pharmacology Oxazines Plant Extracts - pharmacology Receptors, N-Methyl-D-Aspartate - metabolism Reference Standards transient forebrain ischemia |
| title | Berberry Extract Reduces Neuronal Damage and N-Methyl-D-aspartate Receptor 1 Immunoreactivity in the Gerbil Hippocampus after Transient Forebrain Ischemia |
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