Mitochondrial regulation of hypoxia-induced increase of adrenomedullin mRNA in HL-1 cells

Hypoxia upregulates the expression of the cardioprotective peptide adrenomedullin in cardiomyocytes. We characterized this pathway in murine HL-1 cardiomyocytes. Inhibition of mitochondrial complexes I, III, and IV largely, but not completely, reduced hypoxic adrenomedullin mRNA increase in gas-impe...

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Veröffentlicht in:	Biochemical and biophysical research communications 2006-05, Vol.343 (3), p.885-892
Hauptverfasser:	Pfeil, Uwe, Paddenberg, Renate, Kummer, Wolfgang
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenomedullin Animals Cardiomyocytes Cell Hypoxia Cell Line Electron Transport Electron Transport Chain Complex Proteins - physiology Electron Transport Complex II - physiology Flavoproteins - physiology Gene Expression Regulation HL-1 cells Hypoxia Mice Mitochondria Mitochondria, Heart - metabolism Oxygen Peptides - genetics Peptides - metabolism Reactive oxygen species Reactive Oxygen Species - metabolism RNA, Messenger - biosynthesis Up-Regulation
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