Modulation of neuronal excitability by intracellular calcium buffering: From spiking to bursting

We have investigated the detailed regulation of neuronal firing pattern by the cytosolic calcium buffering capacity using a combination of mathematical modeling and patch–clamp recording in acute slice. Theoretical results show that a high calcium buffer concentration alters the characteristic regul...

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Veröffentlicht in:	Cell calcium (Edinburgh) 2006-05, Vol.39 (5), p.455-466
Hauptverfasser:	Roussel, C., Erneux, T., Schiffmann, S.N., Gall, D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Buffers Bursting Calcium - metabolism Calcium - pharmacology Calcium buffering Calcium Signaling - drug effects Calcium Signaling - physiology Cerebellar granule cell Chelating Agents - metabolism Chelating Agents - pharmacology Cytosol - metabolism Egtazic Acid - analogs & derivatives Egtazic Acid - metabolism Egtazic Acid - pharmacology Excitability Mathematical model Mice Mice, Inbred C57BL Models, Theoretical Neurons - drug effects Neurons - metabolism Patch-Clamp Techniques Patch–clamp
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