Tyrosine phosphatase PTP1B interacts with TRPV6 in vivo and plays a role in TRPV6-mediated calcium influx in HEK293 cells

This study investigates the role of tyrosine phosphorylation and dephosphorylation in the regulation of the Ca 2+ permeant TRPV6 channel. HEK293 cells co-transfected with TRPV6 and the tyrosine phosphatase PTP1B show a constitutive Ca 2+ entry which was independent of tyrosine phosphorylation under...

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Veröffentlicht in:	Cellular signalling 2005-08, Vol.17 (8), p.951-960
Hauptverfasser:	Sternfeld, Lutz, Krause, Elmar, Schmid, Andreas, Anderie, Ines, Latas, Anna, Al-Shaldi, Hajaj, Köhl, Andreas, Evers, Katrin, Hofer, Hans Werner, Schulz, Irene
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bimolecular fluorescence complementation Blotting, Western Calcium - chemistry Calcium - metabolism Calcium Channels - metabolism Cell Line Cloning, Molecular GFP Green Fluorescent Proteins - metabolism Humans Immunoprecipitation Microscopy, Video Phosphorylation Plasmids - metabolism Protein Binding Protein Tyrosine Phosphatase, Non-Receptor Type 1 Protein Tyrosine Phosphatases - chemistry Protein Tyrosine Phosphatases - physiology Rats SOCE Spectrometry, Fluorescence Src src-Family Kinases - metabolism Time Factors Transfection TRPV Cation Channels Tyrosine - chemistry Tyrosine - metabolism Vanadates - pharmacology
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