The MTHFR C677T Polymorphism and Colorectal Cancer: The Multiethnic Cohort Study

Methylenetetrahydrofolate reductase (MTHFR) is a key regulatory enzyme in the metabolism of folate, a nutrient that has been inversely related to colorectal cancer risk. The common C677T variant in the MTHFR gene results in a reduced activity of this enzyme, thereby increasing the availability of fo...

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Veröffentlicht in:	Cancer epidemiology, biomarkers & prevention biomarkers & prevention, 2005-05, Vol.14 (5), p.1198-1203
Hauptverfasser:	LE MARCHAND, Loic, WILKENS, Lynne R, KOLONEL, Laurence N, HENDERSON, Brian E
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Alcohol Drinking - epidemiology Alleles Biological and medical sciences Case-Control Studies Cohort Studies Colorectal Neoplasms - epidemiology Colorectal Neoplasms - ethnology Colorectal Neoplasms - genetics Diet Surveys Ethnic Groups - classification Ethnic Groups - genetics Ethnic Groups - statistics & numerical data Female Folic Acid - administration & dosage Gastroenterology. Liver. Pancreas. Abdomen Gene Frequency Genotype Hawaii - epidemiology Humans Los Angeles - epidemiology Male Medical sciences Methylenetetrahydrofolate Reductase (NADPH2) - genetics Middle Aged Neoplasm Staging Polymerase Chain Reaction Polymorphism, Genetic Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Tumors
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