Insect renal tubules constitute a cell-autonomous immune system that protects the organism against bacterial infection

Innate immunity is a widespread and important defence against microbial attack, which in insects is thought to originate mainly in the fat body. Here we demonstrate that the fluid-transporting Malpighian (renal) tubule of Drosophila melanogaster constitutes an autonomous immune-sensing tissue utilis...

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Veröffentlicht in:	Insect biochemistry and molecular biology 2005-07, Vol.35 (7), p.741-754
Hauptverfasser:	McGettigan, J., McLennan, R.K.J., Broderick, K.E., Kean, L., Allan, A.K., Cabrero, P., Regulski, M.R., Pollock, V.P., Gould, G.W., Davies, S.-A., Dow, J.A.T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals antimicrobial peptides Diptericin Drosophila Drosophila melanogaster Drosophila melanogaster - immunology Drosophila Proteins enzyme activity Escherichia coli Escherichia coli - immunology Gene Expression - immunology gene overexpression immune response immune system insect immunity Insect Proteins - metabolism Lipopolysaccharides Malpighian tubules Malpighian Tubules - immunology mortality NADPH Dehydrogenase - metabolism Nitric oxide Nitric Oxide - physiology Nitric Oxide Synthase - metabolism Signal Transduction Survival targetted gene expression Time Factors transgenes
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